5ers - Revision history

OCA at 08:19, 12 July 2023

OCA — Wed, 12 Jul 2023 08:19:28 GMT

←Older revision		Revision as of 08:19, 12 July 2023
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	<StructureSection load='5ers' size='340' side='right'caption='[[5ers]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5ers' size='340' side='right'caption='[[5ers]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ers]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ERS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ers]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ERS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gphn, Gph ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ers FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ers OCA], [~~http~~://pdbe.org/5ers PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ers RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ers PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ers ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ers FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ers OCA], [https://pdbe.org/5ers PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ers RCSB], [https://www.ebi.ac.uk/pdbsum/5ers PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ers ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref>	+	[https://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kasaragod, V B~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Schindelin, H~~]]	+	[[Category: Kasaragod VB]]
-	[[Category: ~~Amp with mg]]~~	+	[[Category: Schindelin H]]
-	~~[[Category: Moco]]~~	+
-	~~[[Category: Moco and wco biosynthesis]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:10, 22 April 2020

OCA — Wed, 22 Apr 2020 07:10:59 GMT

←Older revision		Revision as of 07:10, 22 April 2020
Line 1:		Line 1:

	==GephE in complex with Mg(2+) - AMP==		==GephE in complex with Mg(2+) - AMP==
-	<StructureSection load='5ers' size='340' side='right' caption='[[5ers]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='5ers' size='340' side='right'caption='[[5ers]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ers]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ERS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ers]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ERS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ers FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ers OCA], [http://pdbe.org/5ers PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ers RCSB], [http://www.ebi.ac.uk/pdbsum/5ers PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Gphn, Gph ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ers FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ers OCA], [http://pdbe.org/5ers PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ers RCSB], [http://www.ebi.ac.uk/pdbsum/5ers PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ers ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5ers" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ers" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gephyrin\|Gephyrin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Kasaragod, V B]]		[[Category: Kasaragod, V B]]
	[[Category: Schindelin, H]]		[[Category: Schindelin, H]]

OCA at 05:47, 11 May 2016

OCA — Wed, 11 May 2016 05:47:46 GMT

←Older revision		Revision as of 05:47, 11 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ers is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==GephE in complex with Mg(2+) - AMP==
		+	<StructureSection load='5ers' size='340' side='right' caption='[[5ers]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ers]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ERS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ERS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ers FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ers OCA], [http://pdbe.org/5ers PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ers RCSB], [http://www.ebi.ac.uk/pdbsum/5ers PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The molybdenum cofactor (Moco) is essential for the catalytic activity of all molybdenum-containing enzymes with the exception of nitrogenase. Moco biosynthesis follows an evolutionarily highly conserved pathway and genetic deficiencies in the corresponding human enzymes result in Moco deficiency, which manifests itself in severe neurological symptoms and death in childhood. In humans the final steps of Moco biosynthesis are catalyzed by gephyrin, specifically the penultimate adenylation of molybdopterin (MPT) by its N-terminal G domain (GephG) and the final metal incorporation by its C-terminal E domain (GephE). To better understand the poorly defined molecular framework of this final step, we determined high-resolution crystal structures of GephE in the apo state and in complex with ADP, AMP, and molybdate. Our data provide novel insights into the catalytic steps leading to final Moco maturation, namely deadenylation as well as molybdate binding and insertion.

-	~~Authors:~~ Kasaragod, V.B., ~~Schindelin, H~~.	+	Structural Framework for Metal Incorporation during Molybdenum Cofactor Biosynthesis.,Kasaragod VB, Schindelin H Structure. 2016 May 3;24(5):782-8. doi: 10.1016/j.str.2016.02.023. Epub 2016 Apr , 21. PMID:27112598<ref>PMID:27112598</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ers" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kasaragod, V B]]
	[[Category: Schindelin, H]]		[[Category: Schindelin, H]]
-	[[Category: ~~Kasaragod, V.B~~]]	+	[[Category: Amp with mg]]
		+	[[Category: Moco]]
		+	[[Category: Moco and wco biosynthesis]]
		+	[[Category: Transferase]]

OCA at 23:21, 20 February 2016

OCA — Sat, 20 Feb 2016 23:21:05 GMT

←Older revision		Revision as of 23:21, 20 February 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ers is ON HOLD	+	The entry 5ers is ON HOLD until Paper Publication

	Authors: Kasaragod, V.B., Schindelin, H.		Authors: Kasaragod, V.B., Schindelin, H.

OCA: Protected "5ers" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 03:17:10 GMT

Protected "5ers" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:17, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5ers is ON HOLD Authors: Kasaragod, V.B., Schindelin, H. Description: Category: Unreleased Structures Category: Schindelin, H [[Category: ...

OCA — Tue, 01 Dec 2015 03:17:09 GMT

New page: '''Unreleased structure''' The entry 5ers is ON HOLD Authors: Kasaragod, V.B., Schindelin, H. Description: Category: Unreleased Structures Category: Schindelin, H [[Category: ...

New page

'''Unreleased structure'''

The entry 5ers is ON HOLD

Authors: Kasaragod, V.B., Schindelin, H.

Description:
[[Category: Unreleased Structures]]
[[Category: Schindelin, H]]
[[Category: Kasaragod, V.B]]