5esj - Revision history

OCA at 08:20, 12 July 2023

OCA — Wed, 12 Jul 2023 08:20:55 GMT

←Older revision		Revision as of 08:20, 12 July 2023
Line 3:		Line 3:
	<StructureSection load='5esj' size='340' side='right'caption='[[5esj]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='5esj' size='340' side='right'caption='[[5esj]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5esj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ESJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5esj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_YJM789 Saccharomyces cerevisiae YJM789]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ESJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TPF:2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL'>TPF</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.15Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ese\|5ese]], [[5esf\|5esf]], [[5esk\|5esk]], [[5esl\|5esl]], [[5esm\|5esm]], [[5esn\|5esn]], [[5esg\|5esg]], [[5esh\|5esh]], [[5esi\|5esi]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TPF:2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL'>TPF</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ERG11, SCY_2394 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=307796 Baker's yeast])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5esj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esj OCA], [https://pdbe.org/5esj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5esj RCSB], [https://www.ebi.ac.uk/pdbsum/5esj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5esj ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5esj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esj OCA], [~~http~~://pdbe.org/5esj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5esj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5esj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5esj ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A6ZSR0_YEAS7 A6ZSR0_YEAS7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
-	~~Bitopic integral membrane proteins with a single transmembrane helix play diverse roles in catalysis, cell signaling,~~ and ~~morphogenesis. Complete monospanning protein structures~~ are ~~needed~~ to ~~show how interaction between the transmembrane helix and catalytic domain might influence association with~~ the membrane ~~and function. We report crystal structures of full~~-~~length Saccharomyces cerevisiae~~ lanosterol 14alpha-demethylase~~, a membrane monospanning cytochrome P450 of the~~ CYP51 ~~family that catalyzes the first postcyclization step~~ in ~~ergosterol biosynthesis and is inhibited by~~ triazole drugs. The ~~structures reveal a~~ well~~-ordered N~~-terminal ~~amphipathic helix preceding a putative transmembrane helix~~ that ~~would constrain~~ the ~~catalytic domain orientation~~ to ~~lie partly~~ in the ~~lipid bilayer~~. The structures ~~locate~~ the ~~substrate lanosterol~~, ~~identify putative substrate and product channels~~, ~~and reveal constrained~~ interactions ~~with~~ triazole ~~antifungal drugs that are important for drug design~~ and ~~understanding drug~~ resistance.	+	Fungal infections frequently affect immunodeficient individuals and are estimated to kill 1.35 million people per annum. Azole antifungals target the membrane-bound cytochrome P450 monooxygenase lanosterol 14alpha-demethylase (CYP51; Erg11p). Mutations in CYP51 can render the widely used triazole drugs less effective. The Candida albicans CYP51 mutation G464S and the double mutation Y132F G464S (Y140F and G464S by Saccharomyces cerevisiae numbering) as well as the CYP51A G54E/R/W mutations of Aspergillus fumigatus (G73E/R/W by S. cerevisiae numbering) have been reproduced in a recombinant C-terminal hexahistidine-tagged version of S. cerevisiae CYP51 (ScErg11p6xHis). Phenotypes and X-ray crystal structures were determined for the mutant enzymes. Liquid microdilution assays showed that the G464S mutation in ScErg11p6xHis conferred no difference in the susceptibility of yeast to triazole drugs but in combination with the Y140F mutation gave a 4-fold reduction in susceptibility to the short-tailed triazole fluconazole. The ScErg11p6xHis Y140F G464S mutant was unstable during purification and was not crystallized. The ScErg11p6xHis G73E/R/W mutations conferred increased susceptibly to all triazoles tested in liquid microdilution assays. High-resolution X-ray crystal structures reveal two different conformations of the ligand itraconazole, including a previously unseen conformation, as well as interactions between the tail of this triazole and the E/W73 residue. This study shows that S. cerevisiae CYP51 adequately represents some but not all mutations in CYP51s of pathogenic fungi. Insight into the molecular mechanisms of resistance mutations in CYP51 will assist the development of inhibitors that will overcome antifungal resistance.

-	~~Architecture~~ of ~~a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer~~.,~~Monk BC, Tomasiak TM~~, Keniya MV~~, Huschmann FU~~, Tyndall JD, ~~O'Connell JD 3rd, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM Proc Natl Acad Sci U S A~~. ~~2014 Mar 11~~;~~111~~(10):~~3865~~-70. doi:, 10.~~1073~~/~~pnas~~.~~1324245111~~. ~~Epub 2014 Feb 3~~. PMID:~~24613931~~<ref>PMID:~~24613931~~</ref>	+	Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14alpha-Demethylase.,Sagatova AA, Keniya MV, Tyndall JDA, Monk BC Antimicrob Agents Chemother. 2018 Feb 23;62(3):e02242-17. doi: , 10.1128/AAC.02242-17. Print 2018 Mar. PMID:29263059<ref>PMID:29263059</ref>

	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	<div class="pdbe-citations 5esj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5esj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Keniya~~, M V~~]]	+	[[Category: Saccharomyces cerevisiae YJM789]]
-	[[Category: Monk~~, B C~~]]	+	[[Category: Keniya MV]]
-	[[Category: Sabherwal, M]]	+	[[Category: Monk BC]]
-	[[Category: Sagatova, A]]	+	[[Category: Sabherwal M]]
-	[[Category: Tyndall~~, J D.A~~]]	+	[[Category: Sagatova A]]
-	[[Category: Wilson~~, R K]]~~	+	[[Category: Tyndall JDA]]
-	~~[[Category: Cyp51]]~~	+	[[Category: Wilson RK]]
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 08:56, 1 January 2020

OCA — Wed, 01 Jan 2020 08:56:01 GMT

←Older revision		Revision as of 08:56, 1 January 2020
Line 1:		Line 1:

	==Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G464S mutant complexed with fluconazole==		==Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G464S mutant complexed with fluconazole==
-	<StructureSection load='5esj' size='340' side='right' caption='[[5esj]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='5esj' size='340' side='right'caption='[[5esj]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5esj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ESJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5esj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ESJ FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Keniya, M V]]		[[Category: Keniya, M V]]
	[[Category: Monk, B C]]		[[Category: Monk, B C]]

OCA at 17:10, 15 November 2017

OCA — Wed, 15 Nov 2017 17:10:07 GMT

←Older revision		Revision as of 17:10, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='5esj' size='340' side='right' caption='[[5esj]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='5esj' size='340' side='right' caption='[[5esj]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5esj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ESJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5esj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ESJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TPF:2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL'>TPF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TPF:2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL'>TPF</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ese\|5ese]], [[5esf\|5esf]], [[5esk\|5esk]], [[5esl\|5esl]], [[5esm\|5esm]], [[5esn\|5esn]], [[5esg\|5esg]], [[5esh\|5esh]], [[5esi\|5esi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ese\|5ese]], [[5esf\|5esf]], [[5esk\|5esk]], [[5esl\|5esl]], [[5esm\|5esm]], [[5esn\|5esn]], [[5esg\|5esg]], [[5esh\|5esh]], [[5esi\|5esi]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ERG11, SCY_2394 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=307796 Baker's yeast])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5esj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esj OCA], [http://pdbe.org/5esj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5esj RCSB], [http://www.ebi.ac.uk/pdbsum/5esj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5esj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5esj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esj OCA], [http://pdbe.org/5esj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5esj RCSB], [http://www.ebi.ac.uk/pdbsum/5esj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5esj ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
	[[Category: Keniya, M V]]		[[Category: Keniya, M V]]
	[[Category: Monk, B C]]		[[Category: Monk, B C]]

OCA at 10:49, 10 December 2016

OCA — Sat, 10 Dec 2016 10:49:28 GMT

←Older revision		Revision as of 10:49, 10 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5esj is ~~ON HOLD until Paper~~ Publication	+	==Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G464S mutant complexed with fluconazole==
		+	<StructureSection load='5esj' size='340' side='right' caption='[[5esj]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5esj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ESJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TPF:2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL'>TPF</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ese\|5ese]], [[5esf\|5esf]], [[5esk\|5esk]], [[5esl\|5esl]], [[5esm\|5esm]], [[5esn\|5esn]], [[5esg\|5esg]], [[5esh\|5esh]], [[5esi\|5esi]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5esj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esj OCA], [http://pdbe.org/5esj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5esj RCSB], [http://www.ebi.ac.uk/pdbsum/5esj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5esj ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bitopic integral membrane proteins with a single transmembrane helix play diverse roles in catalysis, cell signaling, and morphogenesis. Complete monospanning protein structures are needed to show how interaction between the transmembrane helix and catalytic domain might influence association with the membrane and function. We report crystal structures of full-length Saccharomyces cerevisiae lanosterol 14alpha-demethylase, a membrane monospanning cytochrome P450 of the CYP51 family that catalyzes the first postcyclization step in ergosterol biosynthesis and is inhibited by triazole drugs. The structures reveal a well-ordered N-terminal amphipathic helix preceding a putative transmembrane helix that would constrain the catalytic domain orientation to lie partly in the lipid bilayer. The structures locate the substrate lanosterol, identify putative substrate and product channels, and reveal constrained interactions with triazole antifungal drugs that are important for drug design and understanding drug resistance.

-	~~Authors: Sagatova, A~~., Keniya, ~~M.V.~~, ~~Wilson~~, ~~R.K.~~, ~~Sabherwal~~, M., ~~Tyndall~~, ~~J.D.~~A., ~~Monk, B~~.C.	+	Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.,Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD 3rd, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3865-70. doi:, 10.1073/pnas.1324245111. Epub 2014 Feb 3. PMID:24613931<ref>PMID:24613931</ref>

-	~~Description: Saccharomyces cerevisiae CYP51 (Lanosterol 14~~-~~alpha demethylase) G464S mutant complexed with fluconazole~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Tyndall~~, ~~J.D.A~~]]	+	<div class="pdbe-citations 5esj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Keniya, M V]]
		+	[[Category: Monk, B C]]
	[[Category: Sabherwal, M]]		[[Category: Sabherwal, M]]
-	[[Category: Wilson, R.K]]
	[[Category: Sagatova, A]]		[[Category: Sagatova, A]]
-	[[Category: ~~Monk~~, B.C]]	+	[[Category: Tyndall, J D.A]]
-	[[Category: ~~Keniya~~, ~~M.V~~]]	+	[[Category: Wilson, R K]]
		+	[[Category: Cyp51]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 10:52, 23 December 2015

OCA — Wed, 23 Dec 2015 10:52:19 GMT

←Older revision		Revision as of 10:52, 23 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5esj is ON HOLD	+	The entry 5esj is ON HOLD until Paper Publication

	Authors: Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.		Authors: Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.

OCA: Protected "5esj" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 03:18:52 GMT

Protected "5esj" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:18, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5esj is ON HOLD Authors: Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C. Description: Saccharomyces cerevisiae...

OCA — Tue, 01 Dec 2015 03:18:51 GMT

New page: '''Unreleased structure''' The entry 5esj is ON HOLD Authors: Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C. Description: Saccharomyces cerevisiae...

New page

'''Unreleased structure'''

The entry 5esj is ON HOLD

Authors: Sagatova, A., Keniya, M.V., Wilson, R.K., Sabherwal, M., Tyndall, J.D.A., Monk, B.C.

Description: Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) G464S mutant complexed with fluconazole
[[Category: Unreleased Structures]]
[[Category: Tyndall, J.D.A]]
[[Category: Sabherwal, M]]
[[Category: Wilson, R.K]]
[[Category: Sagatova, A]]
[[Category: Monk, B.C]]
[[Category: Keniya, M.V]]