5esy - Revision history

OCA: Redirecting to 8f9y

OCA — Wed, 18 Jan 2023 07:09:08 GMT

Redirecting to 8f9y

←Older revision		Revision as of 07:09, 18 January 2023
Line 1:		Line 1:
-		+	#REDIRECT [[8f9y]] This PDB entry is obsolete and replaced by 8f9y
-	~~==Arabidopsis thaliana SAL1==~~	+
-	~~<StructureSection load='5esy' size='340' side='right'caption='~~[[~~5esy~~]]~~, [[Resolution\|resolution]] 3.05Å' scene=''>~~	+
-	~~== Structural highlights ==~~	+
-	<table><tr><td colspan='2'>[[5esy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ESY FirstGlance]. <br>	+
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAL1, FRY1, At5g63980, MBM17.8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5esy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esy OCA], [http://pdbe.org/5esy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5esy RCSB], [http://www.ebi.ac.uk/pdbsum/5esy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5esy ProSAT]</span></td></tr>	+
-	~~</table>~~	+
-	~~== Function ==~~	+
-	[[http://www.uniprot.org/uniprot/DPNP1_ARATH DPNP1_ARATH]] Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. May play a role in the biosynthesis of sulfate conjugates and RNA processing. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate. Could be considered as a negative regulator of abscisic acid (ABA)- and stress-responsive genes, through modulating the inositol 1,4,5-trisphosphate (IP3) turnover. Is also involved in salt tolerance. Acts as a suppressor of virus- and transgene-induced silencing.<ref>PMID:11485991</ref> <ref>PMID:17993620</ref> <ref>PMID:8721754</ref>	+
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Intracellular signaling during oxidative stress is complex, with organelle-to-nucleus retrograde communication pathways ill-defined or incomplete. Here we identify the 3'-phosphoadenosine 5'-phosphate (PAP) phosphatase SAL1 as a previously unidentified and conserved oxidative stress sensor in plant chloroplasts. Arabidopsis thaliana SAL1 (AtSAL1) senses changes in photosynthetic redox poise, hydrogen peroxide, and superoxide concentrations in chloroplasts via redox regulatory mechanisms. AtSAL1 phosphatase activity is suppressed by dimerization, intramolecular disulfide formation, and glutathionylation, allowing accumulation of its substrate, PAP, a chloroplast stress retrograde signal that regulates expression of plastid redox associated nuclear genes (PRANGs). This ~~redox regulation of SAL1 for activation of chloroplast signaling~~ is ~~conserved in the plant kingdom,~~ and the plant protein has evolved enhanced redox sensitivity compared with its yeast ortholog. Our results indicate that in addition to sulfur metabolism, SAL1 orthologs have evolved secondary functions in oxidative stress sensing in the plant kingdom.	+
-		+
-	~~Sensing and signaling of oxidative stress in chloroplasts~~ by inactivation of the SAL1 phosphoadenosine phosphatase.,Chan KX, Mabbitt PD, Phua SY, Mueller JW, Nisar N, Gigolashvili T, Stroeher E, Grassl J, Arlt W, Estavillo GM, Jackson CJ, Pogson BJ Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4567-E4576. Epub 2016 Jul 18. PMID:27432987<ref>PMID:27432987</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 5esy" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references/>~~	+
-	~~__TOC__~~	+
-	~~</StructureSection>~~	+
-	~~[[Category: Arath]]~~	+
-	~~[[Category: Large Structures]]~~	+
-	~~[[Category: Carr, P D]]~~	+
-	~~[[Category: Chan, K X]]~~	+
-	~~[[Category: Estavillo, G M]]~~	+
-	~~[[Category: Jackson, C J]]~~	+
-	~~[[Category: Mabbitt, P D]]~~	+
-	~~[[Category: Pogson, B J]]~~	+
-	~~[[Category: 3ss']]~~	+
-	~~[[Category: 5'-adenosine bisphosphatase]]~~	+
-	~~[[Category: Drought tolerance]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Redox regulation]]~~	+
-	~~[[Category: Retrograde signaling]]~~	+

OCA at 07:42, 29 April 2020

OCA — Wed, 29 Apr 2020 07:42:50 GMT

←Older revision		Revision as of 07:42, 29 April 2020
Line 1:		Line 1:

	==Arabidopsis thaliana SAL1==		==Arabidopsis thaliana SAL1==
-	<StructureSection load='5esy' size='340' side='right' caption='[[5esy]], [[Resolution\|resolution]] 3.05Å' scene=''>	+	<StructureSection load='5esy' size='340' side='right'caption='[[5esy]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5esy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ESY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5esy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ESY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5esy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esy OCA], [http://pdbe.org/5esy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5esy RCSB], [http://www.ebi.ac.uk/pdbsum/5esy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5esy ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAL1, FRY1, At5g63980, MBM17.8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5esy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esy OCA], [http://pdbe.org/5esy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5esy RCSB], [http://www.ebi.ac.uk/pdbsum/5esy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5esy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Carr, P D]]		[[Category: Carr, P D]]
	[[Category: Chan, K X]]		[[Category: Chan, K X]]
Line 27:		Line 30:
	[[Category: Mabbitt, P D]]		[[Category: Mabbitt, P D]]
	[[Category: Pogson, B J]]		[[Category: Pogson, B J]]
-	[[Category: 3s']]	+	[[Category: 3ss']]
	[[Category: 5'-adenosine bisphosphatase]]		[[Category: 5'-adenosine bisphosphatase]]
	[[Category: Drought tolerance]]		[[Category: Drought tolerance]]

OCA at 20:46, 3 August 2016

OCA — Wed, 03 Aug 2016 20:46:42 GMT

←Older revision		Revision as of 20:46, 3 August 2016
Line 8:		Line 8:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DPNP1_ARATH DPNP1_ARATH]] Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. May play a role in the biosynthesis of sulfate conjugates and RNA processing. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate. Could be considered as a negative regulator of abscisic acid (ABA)- and stress-responsive genes, through modulating the inositol 1,4,5-trisphosphate (IP3) turnover. Is also involved in salt tolerance. Acts as a suppressor of virus- and transgene-induced silencing.<ref>PMID:11485991</ref> <ref>PMID:17993620</ref> <ref>PMID:8721754</ref>		[[http://www.uniprot.org/uniprot/DPNP1_ARATH DPNP1_ARATH]] Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. May play a role in the biosynthesis of sulfate conjugates and RNA processing. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate. Could be considered as a negative regulator of abscisic acid (ABA)- and stress-responsive genes, through modulating the inositol 1,4,5-trisphosphate (IP3) turnover. Is also involved in salt tolerance. Acts as a suppressor of virus- and transgene-induced silencing.<ref>PMID:11485991</ref> <ref>PMID:17993620</ref> <ref>PMID:8721754</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Intracellular signaling during oxidative stress is complex, with organelle-to-nucleus retrograde communication pathways ill-defined or incomplete. Here we identify the 3'-phosphoadenosine 5'-phosphate (PAP) phosphatase SAL1 as a previously unidentified and conserved oxidative stress sensor in plant chloroplasts. Arabidopsis thaliana SAL1 (AtSAL1) senses changes in photosynthetic redox poise, hydrogen peroxide, and superoxide concentrations in chloroplasts via redox regulatory mechanisms. AtSAL1 phosphatase activity is suppressed by dimerization, intramolecular disulfide formation, and glutathionylation, allowing accumulation of its substrate, PAP, a chloroplast stress retrograde signal that regulates expression of plastid redox associated nuclear genes (PRANGs). This redox regulation of SAL1 for activation of chloroplast signaling is conserved in the plant kingdom, and the plant protein has evolved enhanced redox sensitivity compared with its yeast ortholog. Our results indicate that in addition to sulfur metabolism, SAL1 orthologs have evolved secondary functions in oxidative stress sensing in the plant kingdom.
		+
		+	Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase.,Chan KX, Mabbitt PD, Phua SY, Mueller JW, Nisar N, Gigolashvili T, Stroeher E, Grassl J, Arlt W, Estavillo GM, Jackson CJ, Pogson BJ Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4567-E4576. Epub 2016 Jul 18. PMID:27432987<ref>PMID:27432987</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5esy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:31, 26 July 2016

OCA — Tue, 26 Jul 2016 15:31:14 GMT

←Older revision		Revision as of 15:31, 26 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5esy ~~is ON HOLD until Paper Publication~~	+	==Arabidopsis thaliana SAL1==
-		+	<StructureSection load='5esy' size='340' side='right' caption='[[5esy]], [[Resolution\|resolution]] 3.05Å' scene=''>
-	~~Authors~~: ~~Mabbitt~~, P.D., ~~Chan~~, K.X., ~~Estavillo, G~~.M., ~~Carr, P~~.D., ~~Pogson~~, ~~B.J~~., ~~Jackson~~, C.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5esy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ESY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ESY FirstGlance]. <br>
-	~~Description~~: ~~Arabidopsis thaliana SAL1~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5esy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5esy OCA], [http://pdbe.org/5esy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5esy RCSB], [http://www.ebi.ac.uk/pdbsum/5esy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5esy ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: Jackson, C.J]]	+	== Function ==
-	[[Category: Mabbitt, P.D]]	+	[[http://www.uniprot.org/uniprot/DPNP1_ARATH DPNP1_ARATH]] Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS. May play a role in the biosynthesis of sulfate conjugates and RNA processing. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate. Could be considered as a negative regulator of abscisic acid (ABA)- and stress-responsive genes, through modulating the inositol 1,4,5-trisphosphate (IP3) turnover. Is also involved in salt tolerance. Acts as a suppressor of virus- and transgene-induced silencing.<ref>PMID:11485991</ref> <ref>PMID:17993620</ref> <ref>PMID:8721754</ref>
-	[[Category: Pogson, B.J]]	+	== References ==
-	[[Category: ~~Estavillo, G.M~~]]	+	<references/>
-	[[Category: ~~Chan, K.X~~]]	+	__TOC__
-	[[Category: ~~Carr, P.D~~]]	+	</StructureSection>
		+	[[Category: Carr, P D]]
		+	[[Category: Chan, K X]]
		+	[[Category: Estavillo, G M]]
		+	[[Category: Jackson, C J]]
		+	[[Category: Mabbitt, P D]]
		+	[[Category: Pogson, B J]]
		+	[[Category: 3s']]
		+	[[Category: 5'-adenosine bisphosphatase]]
		+	[[Category: Drought tolerance]]
		+	[[Category: Hydrolase]]
		+	[[Category: Redox regulation]]
		+	[[Category: Retrograde signaling]]

OCA at 12:13, 16 December 2015

OCA — Wed, 16 Dec 2015 12:13:47 GMT

←Older revision		Revision as of 12:13, 16 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5esy is ON HOLD	+	The entry 5esy is ON HOLD until Paper Publication

	Authors: Mabbitt, P.D., Chan, K.X., Estavillo, G.M., Carr, P.D., Pogson, B.J., Jackson, C.J.		Authors: Mabbitt, P.D., Chan, K.X., Estavillo, G.M., Carr, P.D., Pogson, B.J., Jackson, C.J.

OCA: Protected "5esy" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 03:19:35 GMT

Protected "5esy" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:19, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5esy is ON HOLD Authors: Mabbitt, P.D., Chan, K.X., Estavillo, G.M., Carr, P.D., Pogson, B.J., Jackson, C.J. Description: Arabidopsis thaliana SAL1...

OCA — Tue, 01 Dec 2015 03:19:33 GMT

New page: '''Unreleased structure''' The entry 5esy is ON HOLD Authors: Mabbitt, P.D., Chan, K.X., Estavillo, G.M., Carr, P.D., Pogson, B.J., Jackson, C.J. Description: Arabidopsis thaliana SAL1...

New page

'''Unreleased structure'''

The entry 5esy is ON HOLD

Authors: Mabbitt, P.D., Chan, K.X., Estavillo, G.M., Carr, P.D., Pogson, B.J., Jackson, C.J.

Description: Arabidopsis thaliana SAL1
[[Category: Unreleased Structures]]
[[Category: Jackson, C.J]]
[[Category: Mabbitt, P.D]]
[[Category: Pogson, B.J]]
[[Category: Estavillo, G.M]]
[[Category: Chan, K.X]]
[[Category: Carr, P.D]]