5evd - Revision history

OCA at 11:20, 3 January 2024

OCA — Wed, 03 Jan 2024 11:20:55 GMT

←Older revision		Revision as of 11:20, 3 January 2024
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	<StructureSection load='5evd' size='340' side='right'caption='[[5evd]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5evd' size='340' side='right'caption='[[5evd]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5evd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas~~ maltophilia~~" hugh and ryschenkow 1961~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EVD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5evd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia Stenotrophomonas maltophilia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EVD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VC2:(3S,5S,7AR)-2,2-DIMETHYL-5-(SULFANYLMETHYL)TETRAHYDRO[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>VC2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VC2:(3S,5S,7AR)-2,2-DIMETHYL-5-(SULFANYLMETHYL)TETRAHYDRO[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>VC2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5evd OCA], [https://pdbe.org/5evd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5evd RCSB], [https://www.ebi.ac.uk/pdbsum/5evd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5evd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5evd OCA], [https://pdbe.org/5evd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5evd RCSB], [https://www.ebi.ac.uk/pdbsum/5evd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5evd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BLA1_STEMA BLA1_STEMA]] Has a high activity against imipenem.	+	[https://www.uniprot.org/uniprot/BLA1_STEMA BLA1_STEMA] Has a high activity against imipenem.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pseudomonas maltophilia hugh and ryschenkow 1961]]
-	[[Category: Beta-lactamase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hinchliffe, P~~]]	+	[[Category: Stenotrophomonas maltophilia]]
-	[[Category: ~~Spencer, J~~]]	+	[[Category: Hinchliffe P]]
-	[[Category: ~~Antibiotic resistance]]~~	+	[[Category: Spencer J]]
-	~~[[Category: Carbapenemase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 06:49, 14 April 2021

OCA — Wed, 14 Apr 2021 06:49:14 GMT

←Older revision		Revision as of 06:49, 14 April 2021
Line 3:		Line 3:
	<StructureSection load='5evd' size='340' side='right'caption='[[5evd]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5evd' size='340' side='right'caption='[[5evd]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5evd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EVD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5evd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EVD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VC2:(3S,5S,7AR)-2,2-DIMETHYL-5-(SULFANYLMETHYL)TETRAHYDRO[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>VC2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VC2:(3S,5S,7AR)-2,2-DIMETHYL-5-(SULFANYLMETHYL)TETRAHYDRO[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>VC2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5evd OCA], [~~http~~://pdbe.org/5evd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5evd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5evd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5evd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5evd OCA], [https://pdbe.org/5evd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5evd RCSB], [https://www.ebi.ac.uk/pdbsum/5evd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5evd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BLA1_STEMA BLA1_STEMA]] Has a high activity against imipenem.	+	[[https://www.uniprot.org/uniprot/BLA1_STEMA BLA1_STEMA]] Has a high activity against imipenem.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:46, 29 April 2020

OCA — Wed, 29 Apr 2020 07:46:30 GMT

←Older revision		Revision as of 07:46, 29 April 2020
Line 1:		Line 1:

	==Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazolidine inhibitor D-VC26==		==Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazolidine inhibitor D-VC26==
-	<StructureSection load='5evd' size='340' side='right' caption='[[5evd]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5evd' size='340' side='right'caption='[[5evd]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5evd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EVD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5evd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"pseudomonas_maltophilia"_hugh_and_ryschenkow_1961 "pseudomonas maltophilia" hugh and ryschenkow 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EVD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VC2:(3S,5S,7AR)-2,2-DIMETHYL-5-(SULFANYLMETHYL)TETRAHYDRO[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>VC2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VC2:(3S,5S,7AR)-2,2-DIMETHYL-5-(SULFANYLMETHYL)TETRAHYDRO[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>VC2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5evd OCA], [http://pdbe.org/5evd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5evd RCSB], [http://www.ebi.ac.uk/pdbsum/5evd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5evd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5evd OCA], [http://pdbe.org/5evd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5evd RCSB], [http://www.ebi.ac.uk/pdbsum/5evd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5evd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5evd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5evd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Pseudomonas maltophilia hugh and ryschenkow 1961]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Hinchliffe, P]]		[[Category: Hinchliffe, P]]
	[[Category: Spencer, J]]		[[Category: Spencer, J]]

OCA at 06:36, 26 July 2016

OCA — Tue, 26 Jul 2016 06:36:45 GMT

←Older revision		Revision as of 06:36, 26 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VC2:(3S,5S,7AR)-2,2-DIMETHYL-5-(SULFANYLMETHYL)TETRAHYDRO[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>VC2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VC2:(3S,5S,7AR)-2,2-DIMETHYL-5-(SULFANYLMETHYL)TETRAHYDRO[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>VC2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5evd OCA], [http://pdbe.org/5evd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5evd RCSB], [http://www.ebi.ac.uk/pdbsum/5evd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5evd OCA], [http://pdbe.org/5evd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5evd RCSB], [http://www.ebi.ac.uk/pdbsum/5evd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5evd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BLA1_STEMA BLA1_STEMA]] Has a high activity against imipenem.		[[http://www.uniprot.org/uniprot/BLA1_STEMA BLA1_STEMA]] Has a high activity against imipenem.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Metallo-beta-lactamases (MBLs) hydrolyze almost all beta-lactam antibiotics and are unaffected by clinically available beta-lactamase inhibitors (betaLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of betaLIs effective against all enzymes. Bisthiazolidines (BTZs) are carboxylate-containing, bicyclic compounds, considered as penicillin analogs with an additional free thiol. Here, we show both l- and d-BTZ enantiomers are micromolar competitive betaLIs of all MBL classes in vitro, with Kis of 6-15 microM or 36-84 microM for subclass B1 MBLs (IMP-1 and BcII, respectively), and 10-12 microM for the B3 enzyme L1. Against the B2 MBL Sfh-I, the l-BTZ enantiomers exhibit 100-fold lower Kis (0.26-0.36 microM) than d-BTZs (26-29 microM). Importantly, cell-based time-kill assays show BTZs restore beta-lactam susceptibility of Escherichia coli-producing MBLs (IMP-1, Sfh-1, BcII, and GOB-18) and, significantly, an extensively drug-resistant Stenotrophomonas maltophilia clinical isolate expressing L1. BTZs therefore inhibit the full range of MBLs and potentiate beta-lactam activity against producer pathogens. X-ray crystal structures reveal insights into diverse BTZ binding modes, varying with orientation of the carboxylate and thiol moieties. BTZs bind the di-zinc centers of B1 (IMP-1; BcII) and B3 (L1) MBLs via the free thiol, but orient differently depending upon stereochemistry. In contrast, the l-BTZ carboxylate dominates interactions with the monozinc B2 MBL Sfh-I, with the thiol uninvolved. d-BTZ complexes most closely resemble beta-lactam binding to B1 MBLs, but feature an unprecedented disruption of the D120-zinc interaction. Cross-class MBL inhibition therefore arises from the unexpected versatility of BTZ binding.
		+
		+	Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes.,Hinchliffe P, Gonzalez MM, Mojica MF, Gonzalez JM, Castillo V, Saiz C, Kosmopoulou M, Tooke CL, Llarrull LI, Mahler G, Bonomo RA, Vila AJ, Spencer J Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3745-54. doi:, 10.1073/pnas.1601368113. Epub 2016 Jun 14. PMID:27303030<ref>PMID:27303030</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5evd" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:07, 2 June 2016

OCA — Thu, 02 Jun 2016 06:07:48 GMT

←Older revision		Revision as of 06:07, 2 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5evd is ON HOLD until Paper Publication~~	+	==Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazolidine inhibitor D-VC26==
-		+	<StructureSection load='5evd' size='340' side='right' caption='[[5evd]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors: Hinchliffe, P., Spencer, J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5evd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EVD FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazolidine inhibitor D-VC26	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VC2:(3S,5S,7AR)-2,2-DIMETHYL-5-(SULFANYLMETHYL)TETRAHYDRO[1,3]THIAZOLO[4,3-B][1,3]THIAZOLE-3-CARBOXYLIC+ACID'>VC2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5evd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5evd OCA], [http://pdbe.org/5evd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5evd RCSB], [http://www.ebi.ac.uk/pdbsum/5evd PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BLA1_STEMA BLA1_STEMA]] Has a high activity against imipenem.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-lactamase]]
		+	[[Category: Hinchliffe, P]]
	[[Category: Spencer, J]]		[[Category: Spencer, J]]
-	[[Category: ~~Hinchliffe, P~~]]	+	[[Category: Antibiotic resistance]]
		+	[[Category: Carbapenemase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]

OCA at 15:02, 2 December 2015

OCA — Wed, 02 Dec 2015 15:02:51 GMT

←Older revision		Revision as of 15:02, 2 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5evd is ON HOLD	+	The entry 5evd is ON HOLD until Paper Publication

	Authors: Hinchliffe, P., Spencer, J.		Authors: Hinchliffe, P., Spencer, J.

OCA: Protected "5evd" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 03:26:10 GMT

Protected "5evd" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:26, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5evd is ON HOLD Authors: Hinchliffe, P., Spencer, J. Description: Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazol...

OCA — Tue, 01 Dec 2015 03:26:09 GMT

New page: '''Unreleased structure''' The entry 5evd is ON HOLD Authors: Hinchliffe, P., Spencer, J. Description: Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazol...

New page

'''Unreleased structure'''

The entry 5evd is ON HOLD

Authors: Hinchliffe, P., Spencer, J.

Description: Crystal structure of the metallo-beta-lactamase L1 in complex with the bisthiazolidine inhibitor D-VC26
[[Category: Unreleased Structures]]
[[Category: Spencer, J]]
[[Category: Hinchliffe, P]]