5eve - Revision history

OCA at 08:27, 12 July 2023

OCA — Wed, 12 Jul 2023 08:27:18 GMT

←Older revision		Revision as of 08:27, 12 July 2023
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	<StructureSection load='5eve' size='340' side='right'caption='[[5eve]], [[Resolution\|resolution]] 2.55Å' scene=''>		<StructureSection load='5eve' size='340' side='right'caption='[[5eve]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5eve]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ambar Ambar~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EVE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5eve]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ambrosia_artemisiifolia Ambrosia artemisiifolia] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EVE FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5em0\|5em0]]~~, [[~~5em1~~\|~~5em1]], [[5ev0\|5ev0~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.55Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5eve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eve OCA], [~~http~~://pdbe.org/5eve PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5eve RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5eve PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5eve ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eve OCA], [https://pdbe.org/5eve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eve RCSB], [https://www.ebi.ac.uk/pdbsum/5eve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eve ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q2KN24_AMBAR Q2KN24_AMBAR]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.[RuleBase:RU003908]	+	[https://www.uniprot.org/uniprot/Q2KN24_AMBAR Q2KN24_AMBAR] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.[RuleBase:RU003908]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ambar~~]]	+	[[Category: Ambrosia artemisiifolia]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chruszcz, M~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Garrett, J~~]]	+	[[Category: Chruszcz M]]
-	[[Category: ~~Offermann, L R~~]]	+	[[Category: Garrett J]]
-	[[Category: ~~Schlachter, C R~~]]	+	[[Category: Offermann LR]]
-	[[Category: ~~Allergen~~]]	+	[[Category: Schlachter CR]]

OCA at 07:46, 29 April 2020

OCA — Wed, 29 Apr 2020 07:46:36 GMT

←Older revision		Revision as of 07:46, 29 April 2020
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	==Crystal structure of Amb a 8 in complex with poly-Pro10==		==Crystal structure of Amb a 8 in complex with poly-Pro10==
-	<StructureSection load='5eve' size='340' side='right' caption='[[5eve]], [[Resolution\|resolution]] 2.55Å' scene=''>	+	<StructureSection load='5eve' size='340' side='right'caption='[[5eve]], [[Resolution\|resolution]] 2.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5eve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EVE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5eve]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ambar Ambar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EVE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5em0\|5em0]], [[5em1\|5em1]], [[5ev0\|5ev0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5em0\|5em0]], [[5em1\|5em1]], [[5ev0\|5ev0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5eve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eve OCA], [http://pdbe.org/5eve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eve RCSB], [http://www.ebi.ac.uk/pdbsum/5eve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eve ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5eve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eve OCA], [http://pdbe.org/5eve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eve RCSB], [http://www.ebi.ac.uk/pdbsum/5eve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eve ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5eve" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5eve" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Profilin 3D Structures\|Profilin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Ambar]]
		+	[[Category: Large Structures]]
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]
	[[Category: Garrett, J]]		[[Category: Garrett, J]]

OCA at 08:10, 10 August 2016

OCA — Wed, 10 Aug 2016 08:10:11 GMT

←Older revision		Revision as of 08:10, 10 August 2016
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[5eve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EVE FirstGlance]. <br>		<table><tr><td colspan='2'>[[5eve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EVE FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5em0\|5em0]], [[5em1\|5em1]], [[5ev0\|5ev0]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5em0\|5em0]], [[5em1\|5em1]], [[5ev0\|5ev0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eve OCA], [http://pdbe.org/5eve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eve RCSB], [http://www.ebi.ac.uk/pdbsum/5eve PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eve OCA], [http://pdbe.org/5eve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eve RCSB], [http://www.ebi.ac.uk/pdbsum/5eve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eve ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:22, 20 June 2016

OCA — Mon, 20 Jun 2016 15:22:44 GMT

←Older revision		Revision as of 15:22, 20 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5eve is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Amb a 8 in complex with poly-Pro10==
		+	<StructureSection load='5eve' size='340' side='right' caption='[[5eve]], [[Resolution\|resolution]] 2.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5eve]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EVE FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5em0\|5em0]], [[5em1\|5em1]], [[5ev0\|5ev0]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eve OCA], [http://pdbe.org/5eve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eve RCSB], [http://www.ebi.ac.uk/pdbsum/5eve PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q2KN24_AMBAR Q2KN24_AMBAR]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.[RuleBase:RU003908]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ragweed allergens affect several million people in the USA and Canada. To date, only two ragweed allergens, Amb t 5 and Amb a 11, have their structures determined and deposited to the Protein Data Bank. Here, we present structures of methylated ragweed allergen Amb a 8, Amb a 8 in the presence of poly-L-proline and Art v 4 (mugwort allergen). Amb a 8 and Art v 4 are panallergens belonging to the profilin family of proteins. They share significant sequence and structural similarities which results in cross-recognition by IgE antibodies. Molecular and immunological properties of Amb a 8 and Art v 4 are compared to those of Bet v 2 (birch pollen allergen), as well as to other allergenic profilins. We purified recombinant allergens that are recognized by patient IgE and are highly cross-reactive. It was determined that the analyzed allergens are relatively unstable. Structures of Amb a 8 in complex with poly-L-proline10 or poly-L-proline14 are the first structures of the plant profilin in complex with proline-rich peptides. Amb a 8 binds the poly-L-proline in a mode similar to that observed in human, mouse and P. falciparum profilin-peptide complexes. However, only some of residues that form the peptide binding site are conserved.

-	~~Authors: Offermann~~, ~~L.R~~., Schlachter, ~~C.R.~~, ~~Garrett~~, J., ~~Chruszcz~~, M.	+	Structural, functional and immunological characterization of profilin panallergens amb a 8, Art v 4, and Bet v 2.,Offermann LR, Schlachter CR, Perdue ML, Majorek KA, He JZ, Booth WT, Garrett J, Kowal K, Chruszcz M J Biol Chem. 2016 May 26. pii: jbc.M116.733659. PMID:27231348<ref>PMID:27231348</ref>

-	~~Description: Crystal structure of Amb~~ a ~~8 in complex with poly-Pro10~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Garrett, J]]~~	+	<div class="pdbe-citations 5eve" style="background-color:#fffaf0;"></div>
-	~~[[Category: Schlachter, C.R]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]
-	[[Category: Offermann, L.R]]	+	[[Category: Garrett, J]]
		+	[[Category: Offermann, L R]]
		+	[[Category: Schlachter, C R]]
		+	[[Category: Allergen]]

OCA at 12:17, 9 December 2015

OCA — Wed, 09 Dec 2015 12:17:00 GMT

←Older revision		Revision as of 12:17, 9 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5eve is ON HOLD	+	The entry 5eve is ON HOLD until Paper Publication

	Authors: Offermann, L.R., Schlachter, C.R., Garrett, J., Chruszcz, M.		Authors: Offermann, L.R., Schlachter, C.R., Garrett, J., Chruszcz, M.

OCA at 15:02, 2 December 2015

OCA — Wed, 02 Dec 2015 15:02:54 GMT

←Older revision		Revision as of 15:02, 2 December 2015
Line 3:		Line 3:
	The entry 5eve is ON HOLD		The entry 5eve is ON HOLD

-	Authors: Offermann, L.R., Schlachter, C.R, Garrett, J., Chruszcz, M.	+	Authors: Offermann, L.R., Schlachter, C.R., Garrett, J., Chruszcz, M.

	Description: Crystal structure of Amb a 8 in complex with poly-Pro10		Description: Crystal structure of Amb a 8 in complex with poly-Pro10
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Schlachter, C.R~~, Garrett, J~~]]	+	[[Category: Garrett, J]]
		+	[[Category: Schlachter, C.R]]
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]
	[[Category: Offermann, L.R]]		[[Category: Offermann, L.R]]

OCA: Protected "5eve" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 03:26:12 GMT

Protected "5eve" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:26, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5eve is ON HOLD Authors: Offermann, L.R., Schlachter, C.R, Garrett, J., Chruszcz, M. Description: Crystal structure of Amb a 8 in complex with poly...

OCA — Tue, 01 Dec 2015 03:26:11 GMT

New page: '''Unreleased structure''' The entry 5eve is ON HOLD Authors: Offermann, L.R., Schlachter, C.R, Garrett, J., Chruszcz, M. Description: Crystal structure of Amb a 8 in complex with poly...

New page

'''Unreleased structure'''

The entry 5eve is ON HOLD

Authors: Offermann, L.R., Schlachter, C.R, Garrett, J., Chruszcz, M.

Description: Crystal structure of Amb a 8 in complex with poly-Pro10
[[Category: Unreleased Structures]]
[[Category: Schlachter, C.R, Garrett, J]]
[[Category: Chruszcz, M]]
[[Category: Offermann, L.R]]