5ez6 - Revision history

OCA at 08:35, 12 July 2023

OCA — Wed, 12 Jul 2023 08:35:28 GMT

←Older revision		Revision as of 08:35, 12 July 2023
Line 3:		Line 3:
	<StructureSection load='5ez6' size='340' side='right'caption='[[5ez6]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5ez6' size='340' side='right'caption='[[5ez6]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ez6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZ6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ez6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EZ6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GDP:GUANOSINE~~-~~5-DIPHOSPHATE'>GDP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~RHOA, ARH12, ARHA, RHO12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id~~=~~9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ez6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ez6 OCA], [~~http~~://pdbe.org/5ez6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ez6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ez6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ez6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ez6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ez6 OCA], [https://pdbe.org/5ez6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ez6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ez6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ez6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>	+	[https://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, J]]	+	[[Category: Li J]]
-	[[Category: Ma, L]]	+	[[Category: Ma L]]
-	[[Category: Ma, S]]	+	[[Category: Ma S]]
-	[[Category: Miao, L]]	+	[[Category: Miao L]]
-	[[Category: Wang, F]]	+	[[Category: Wang F]]
-	[[Category: Yan, Z]]	+	[[Category: Yan Z]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Gdp binding]]~~	+
-	~~[[Category: Gtp binding]]~~	+
-	~~[[Category: Gtpase activity]]~~	+
-	~~[[Category: Nucleotide binding]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:51, 29 April 2020

OCA — Wed, 29 Apr 2020 07:51:48 GMT

←Older revision		Revision as of 07:51, 29 April 2020
Line 1:		Line 1:

	==Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA==		==Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA==
-	<StructureSection load='5ez6' size='340' side='right' caption='[[5ez6]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5ez6' size='340' side='right'caption='[[5ez6]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ez6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ez6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EZ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ez6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ez6 OCA], [http://pdbe.org/5ez6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ez6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ez6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ez6 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RHOA, ARH12, ARHA, RHO12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ez6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ez6 OCA], [http://pdbe.org/5ez6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ez6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ez6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ez6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>		[[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
		+
		+	==See Also==
		+	*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Li, J]]		[[Category: Li, J]]
	[[Category: Ma, L]]		[[Category: Ma, L]]

OCA at 02:08, 11 December 2016

OCA — Sun, 11 Dec 2016 02:08:55 GMT

←Older revision		Revision as of 02:08, 11 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ez6 is ~~ON HOLD until Paper Publication~~	+	==Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA==
-		+	<StructureSection load='5ez6' size='340' side='right' caption='[[5ez6]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: ~~Yan~~, Z., Ma, S., ~~Zhang~~, Y., Ma, L., ~~Wang, F~~., ~~Li, J~~., ~~Miao~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ez6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EZ6 FirstGlance]. <br>
-	~~Description: Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~[[Category: Unreleased Structures]]~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ez6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ez6 OCA], [http://pdbe.org/5ez6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ez6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ez6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ez6 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Li, J]]		[[Category: Li, J]]
-	[[Category: Miao, L]]
-	[[Category: Zhang, Y]]
	[[Category: Ma, L]]		[[Category: Ma, L]]
	[[Category: Ma, S]]		[[Category: Ma, S]]
		+	[[Category: Miao, L]]
	[[Category: Wang, F]]		[[Category: Wang, F]]
	[[Category: Yan, Z]]		[[Category: Yan, Z]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Gdp binding]]
		+	[[Category: Gtp binding]]
		+	[[Category: Gtpase activity]]
		+	[[Category: Nucleotide binding]]
		+	[[Category: Protein binding]]
		+	[[Category: Signaling protein]]

OCA at 10:24, 20 June 2016

OCA — Mon, 20 Jun 2016 10:24:13 GMT

←Older revision		Revision as of 10:24, 20 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ez6 is ON HOLD	+	The entry 5ez6 is ON HOLD until Paper Publication

	Authors: Yan, Z., Ma, S., Zhang, Y., Ma, L., Wang, F., Li, J., Miao, L.		Authors: Yan, Z., Ma, S., Zhang, Y., Ma, L., Wang, F., Li, J., Miao, L.

OCA at 12:23, 9 December 2015

OCA — Wed, 09 Dec 2015 12:23:24 GMT

←Older revision		Revision as of 12:23, 9 December 2015
Line 3:		Line 3:
	The entry 5ez6 is ON HOLD		The entry 5ez6 is ON HOLD

-	Authors: ~~Zhaowei yan~~, ~~Sheng~~ Ma, ~~Yan~~ Zhang, La Ma, ~~Feng~~ Wang, ~~Jian~~ Li, ~~Liyan~~ Miao	+	Authors: Yan, Z., Ma, S., Zhang, Y., Ma, L., Wang, F., Li, J., Miao, L.

	Description: Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA		Description: Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Zhaowei Yan~~, ~~Sheng Ma~~, ~~Yan~~ Zhang, La Ma, ~~Feng~~ Wang, ~~Jian Li~~, ~~Liyan Miao~~]]	+	[[Category: Li, J]]
		+	[[Category: Miao, L]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Ma, L]]
		+	[[Category: Ma, S]]
		+	[[Category: Wang, F]]
		+	[[Category: Yan, Z]]

OCA: Protected "5ez6" [edit=sysop:move=sysop]

OCA — Wed, 02 Dec 2015 15:12:03 GMT

Protected "5ez6" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:12, 2 December 2015

OCA: New page: '''Unreleased structure''' The entry 5ez6 is ON HOLD Authors: Zhaowei yan, Sheng Ma, Yan Zhang, La Ma, Feng Wang, Jian Li, Liyan Miao Description: Crystallization and preliminary X-ray...

OCA — Wed, 02 Dec 2015 15:12:01 GMT

New page: '''Unreleased structure''' The entry 5ez6 is ON HOLD Authors: Zhaowei yan, Sheng Ma, Yan Zhang, La Ma, Feng Wang, Jian Li, Liyan Miao Description: Crystallization and preliminary X-ray...

New page

'''Unreleased structure'''

The entry 5ez6 is ON HOLD

Authors: Zhaowei yan, Sheng Ma, Yan Zhang, La Ma, Feng Wang, Jian Li, Liyan Miao

Description: Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA
[[Category: Unreleased Structures]]
[[Category: Zhaowei Yan, Sheng Ma, Yan Zhang, La Ma, Feng Wang, Jian Li, Liyan Miao]]