5f06 - Revision history

OCA at 08:37, 12 July 2023

OCA — Wed, 12 Jul 2023 08:37:47 GMT

←Older revision		Revision as of 08:37, 12 July 2023
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	<StructureSection load='5f06' size='340' side='right'caption='[[5f06]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5f06' size='340' side='right'caption='[[5f06]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F06 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5F06 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f06]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Populus_trichocarpa Populus trichocarpa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F06 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5f06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f06 OCA], [~~http~~://pdbe.org/5f06 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5f06 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5f06 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5f06 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f06 OCA], [https://pdbe.org/5f06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f06 RCSB], [https://www.ebi.ac.uk/pdbsum/5f06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f06 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/U5GTL0_POPTR U5GTL0_POPTR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Didierjean, C]]	+	[[Category: Populus trichocarpa]]
-	[[Category: Gense, F]]	+	[[Category: Didierjean C]]
-	[[Category: Pegeot, H]]	+	[[Category: Gense F]]
-	[[Category: Rouhier, N]]	+	[[Category: Pegeot H]]
-	~~[[Category: Glutathione]]~~	+	[[Category: Rouhier N]]
-	~~[[Category: Ligandin]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:53, 29 April 2020

OCA — Wed, 29 Apr 2020 07:53:31 GMT

←Older revision		Revision as of 07:53, 29 April 2020
Line 1:		Line 1:

	==Crystal structure of glutathione transferase F7 from Populus trichocarpa==		==Crystal structure of glutathione transferase F7 from Populus trichocarpa==
-	<StructureSection load='5f06' size='340' side='right' caption='[[5f06]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5f06' size='340' side='right'caption='[[5f06]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F06 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5F06 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F06 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5F06 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5f06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f06 OCA], [http://pdbe.org/5f06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f06 RCSB], [http://www.ebi.ac.uk/pdbsum/5f06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f06 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5f06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f06 OCA], [http://pdbe.org/5f06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f06 RCSB], [http://www.ebi.ac.uk/pdbsum/5f06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f06 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Didierjean, C]]		[[Category: Didierjean, C]]
	[[Category: Gense, F]]		[[Category: Gense, F]]

OCA at 08:14, 3 August 2017

OCA — Thu, 03 Aug 2017 08:14:41 GMT

←Older revision		Revision as of 08:14, 3 August 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f06 OCA], [http://pdbe.org/5f06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f06 RCSB], [http://www.ebi.ac.uk/pdbsum/5f06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f06 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f06 OCA], [http://pdbe.org/5f06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f06 RCSB], [http://www.ebi.ac.uk/pdbsum/5f06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f06 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The glutathione transferase (GST) gene family is divided into 14 classes in photosynthetic organisms. Among them, the Phi class (GSTF) is composed of a large number of genes that are often induced in response to environmental constraints due to their ability to detoxify xenobiotics, to their peroxidase activity and to their involvement in the biosynthesis and/or transport of secondary metabolites. However, the exact functions of GSTFs from many plants including Populus trichocarpa are unknown. Here, following GSTF1 characterization, we have performed a comparative analysis of the seven other GSTFs found in poplar by systematically evaluating the biochemical and enzymatic properties of the corresponding recombinant proteins and of variants mutated for active site residues and by determining the three-dimensional structures of several representatives. Owing to the presence of a cysteine with a pKa value around 5 in their active site, GSTF3, F7, and F8 displayed a thiol transferase activity in addition to the usual glutathione transferase and peroxidase activities. From structural analyses, it appeared that these dual biochemical properties originate from the existence of a certain variability in the beta1-alpha1 loop. This allows positioning of several active site residues at proximity of the glutathione molecule, which itself remains unchanged in GSTF three-dimensional structures. These results highlight the promiscuity of some GSTFs and that changes of active site residues in some isoforms during evolution generated functional diversity by modifying their activity profile. DATABASE: Structural data are available in the PDB under the accession numbers 5EY6, 5F05, 5F06, and 5F07.
		+
		+	Structural plasticity among glutathione transferase Phi members: natural combination of catalytic residues confers dual biochemical activities.,Pegeot H, Mathiot S, Perrot T, Gense F, Hecker A, Didierjean C, Rouhier N FEBS J. 2017 Jun 16. doi: 10.1111/febs.14138. PMID:28622459<ref>PMID:28622459</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5f06" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 02:09, 11 December 2016

OCA — Sun, 11 Dec 2016 02:09:11 GMT

←Older revision		Revision as of 02:09, 11 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5f06 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of glutathione transferase F7 from Populus trichocarpa==
-		+	<StructureSection load='5f06' size='340' side='right' caption='[[5f06]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: ~~Didierjean~~, C., ~~Rouhier, N~~., ~~Pegeot~~, H., ~~Gense, F~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5f06]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F06 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F06 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of glutathione transferase F7 from Populus trichocarpa~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f06 OCA], [http://pdbe.org/5f06 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f06 RCSB], [http://www.ebi.ac.uk/pdbsum/5f06 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f06 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Didierjean, C]]
		+	[[Category: Gense, F]]
	[[Category: Pegeot, H]]		[[Category: Pegeot, H]]
	[[Category: Rouhier, N]]		[[Category: Rouhier, N]]
-	[[Category: ~~Gense, F~~]]	+	[[Category: Glutathione]]
-	[[Category: ~~Didierjean, C~~]]	+	[[Category: Ligandin]]
		+	[[Category: Transferase]]

OCA at 10:54, 19 October 2016

OCA — Wed, 19 Oct 2016 10:54:46 GMT

←Older revision		Revision as of 10:54, 19 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5f06 is ON HOLD	+	The entry 5f06 is ON HOLD until Paper Publication

	Authors: Didierjean, C., Rouhier, N., Pegeot, H., Gense, F.		Authors: Didierjean, C., Rouhier, N., Pegeot, H., Gense, F.

OCA: Protected "5f06" [edit=sysop:move=sysop]

OCA — Wed, 02 Dec 2015 15:14:28 GMT

Protected "5f06" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:14, 2 December 2015

OCA: New page: '''Unreleased structure''' The entry 5f06 is ON HOLD Authors: Didierjean, C., Rouhier, N., Pegeot, H., Gense, F. Description: Crystal structure of glutathione transferase F7 from Popul...

OCA — Wed, 02 Dec 2015 15:14:27 GMT

New page: '''Unreleased structure''' The entry 5f06 is ON HOLD Authors: Didierjean, C., Rouhier, N., Pegeot, H., Gense, F. Description: Crystal structure of glutathione transferase F7 from Popul...

New page

'''Unreleased structure'''

The entry 5f06 is ON HOLD

Authors: Didierjean, C., Rouhier, N., Pegeot, H., Gense, F.

Description: Crystal structure of glutathione transferase F7 from Populus trichocarpa
[[Category: Unreleased Structures]]
[[Category: Pegeot, H]]
[[Category: Rouhier, N]]
[[Category: Gense, F]]
[[Category: Didierjean, C]]