5f0g - Revision history

OCA at 08:38, 12 July 2023

OCA — Wed, 12 Jul 2023 08:38:26 GMT

←Older revision		Revision as of 08:38, 12 July 2023
Line 1:		Line 1:

	==Structure of the glutathione transferase delta 2 from Drosophila melanogaster==		==Structure of the glutathione transferase delta 2 from Drosophila melanogaster==
-	<StructureSection load='5f0g' size='340' side='right' caption='[[5f0g]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='5f0g' size='340' side='right'caption='[[5f0g]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f0g]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F0G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5F0G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F0G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=K:POTASSIUM+ION'>K</scene~~>, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>GstD2, GSTD2-2, gstD21, CG4181 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~7227 DROME])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f0g OCA], [https://pdbe.org/5f0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f0g RCSB], [https://www.ebi.ac.uk/pdbsum/5f0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f0g ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5f0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f0g OCA], [~~http~~://pdbe.org/5f0g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5f0g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5f0g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5f0g ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GSTD2_DROME GSTD2_DROME]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref>	+	[https://www.uniprot.org/uniprot/GSTD2_DROME GSTD2_DROME] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:

	==See Also==		==See Also==
-	*[[Glutathione S-transferase\|Glutathione S-transferase]]	+	*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Drome]]
-	[[Category: Glutathione transferase]]
-	[[Category: Briand, L]]
-	[[Category: Gonzalez, D]]
-	[[Category: Neiers, F]]
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: ~~Glutathion transferase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Glutathion-s-transferase~~]]	+	[[Category: Briand L]]
-	[[Category: ~~Gst~~]]	+	[[Category: Gonzalez D]]
-	[[Category: ~~Gst delta 2]]~~	+	[[Category: Neiers F]]
-	~~[[Category: Gst-d2]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 14:04, 11 April 2018

OCA — Wed, 11 Apr 2018 14:04:34 GMT

←Older revision		Revision as of 14:04, 11 April 2018
Line 1:		Line 1:

-	==Structure of the ~~glutathion~~ transferase delta 2 from ~~drosophila~~ melanogaster==	+	==Structure of the glutathione transferase delta 2 from Drosophila melanogaster==
	<StructureSection load='5f0g' size='340' side='right' caption='[[5f0g]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5f0g' size='340' side='right' caption='[[5f0g]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f0g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F0G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f0g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F0G FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GstD2, GSTD2-2, gstD21, CG4181 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f0g OCA], [http://pdbe.org/5f0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f0g RCSB], [http://www.ebi.ac.uk/pdbsum/5f0g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f0g ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f0g OCA], [http://pdbe.org/5f0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f0g RCSB], [http://www.ebi.ac.uk/pdbsum/5f0g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f0g ProSAT]</span></td></tr>
Line 10:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GSTD2_DROME GSTD2_DROME]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref>		[[http://www.uniprot.org/uniprot/GSTD2_DROME GSTD2_DROME]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glutathione transferases (GSTs) are ubiquitous key enzymes that catalyse the conjugation of glutathione to xenobiotic compounds in the detoxification process. GSTs have been proposed to play a dual role in the signal termination of insect chemodetection by modifying odorant and tasting molecules and by protecting the chemosensory system. Among the 40 GSTs identified in Drosophila melanogaster, the Delta and Epsilon groups are insect-specific. GSTs Delta and Epsilon may have evolved to serve in detoxification, and have been associated with insecticide resistance. Here, we report the heterologous expression and purification of the D. melanogaster GST Delta 2 (GSTD2). We investigated the capacity of GSTD2 to bind tasting molecules. Among them, we found that isothiocyanates (ITC), insecticidal compounds naturally present in cruciferous plant and perceived as bitter, are good substrates for GSTD2. The X-ray structure of GSTD2 was solved, showing the absence of the classical Ser catalytic residue, conserved in the Delta and Epsilon GSTs. Using molecular dynamics, the interaction of ITC with the GSTD2 three-dimensional structure is analysed and discussed. These findings allow us to consider a biological role for GSTD2 in chemoperception, considering GSTD2 expression in the chemosensory organs and the potential consequences of insect exposure to ITC.
		+
		+	Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification.,Gonzalez D, Fraichard S, Grassein P, Delarue P, Senet P, Nicolai A, Chavanne E, Mucher E, Artur Y, Ferveur JF, Heydel JM, Briand L, Neiers F Insect Biochem Mol Biol. 2018 Mar 22;95:33-43. doi: 10.1016/j.ibmb.2018.03.004. PMID:29578047<ref>PMID:29578047</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5f0g" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutathione S-transferase\|Glutathione S-transferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
	[[Category: Briand, L]]		[[Category: Briand, L]]

OCA at 13:24, 5 April 2017

OCA — Wed, 05 Apr 2017 13:24:28 GMT

←Older revision		Revision as of 13:24, 5 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5f0g is ~~ON HOLD until Paper Publication~~	+	==Structure of the glutathion transferase delta 2 from drosophila melanogaster==
-		+	<StructureSection load='5f0g' size='340' side='right' caption='[[5f0g]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~: ~~Gonzalez~~, D., ~~Briand~~, L., ~~Neiers~~, F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5f0g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F0G FirstGlance]. <br>
-	~~Description~~: ~~Structure~~ of ~~the glutathion~~ transferase ~~delta 2 from drosophila melanogaster~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f0g OCA], [http://pdbe.org/5f0g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f0g RCSB], [http://www.ebi.ac.uk/pdbsum/5f0g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f0g ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GSTD2_DROME GSTD2_DROME]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028).<ref>PMID:22082028</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glutathione transferase]]
		+	[[Category: Briand, L]]
	[[Category: Gonzalez, D]]		[[Category: Gonzalez, D]]
	[[Category: Neiers, F]]		[[Category: Neiers, F]]
-	[[Category: ~~Briand, L~~]]	+	[[Category: Drosophila melanogaster]]
		+	[[Category: Glutathion transferase]]
		+	[[Category: Glutathion-s-transferase]]
		+	[[Category: Gst]]
		+	[[Category: Gst delta 2]]
		+	[[Category: Gst-d2]]
		+	[[Category: Transferase]]

OCA at 11:04, 23 December 2015

OCA — Wed, 23 Dec 2015 11:04:20 GMT

←Older revision		Revision as of 11:04, 23 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5f0g is ON HOLD	+	The entry 5f0g is ON HOLD until Paper Publication

	Authors: Gonzalez, D., Briand, L., Neiers, F.		Authors: Gonzalez, D., Briand, L., Neiers, F.

OCA: Protected "5f0g" [edit=sysop:move=sysop]

OCA — Wed, 09 Dec 2015 12:26:11 GMT

Protected "5f0g" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:26, 9 December 2015

OCA: New page: '''Unreleased structure''' The entry 5f0g is ON HOLD Authors: Gonzalez, D., Briand, L., Neiers, F. Description: Structure of the glutathion transferase delta 2 from drosophila melanoga...

OCA — Wed, 09 Dec 2015 12:26:10 GMT

New page: '''Unreleased structure''' The entry 5f0g is ON HOLD Authors: Gonzalez, D., Briand, L., Neiers, F. Description: Structure of the glutathion transferase delta 2 from drosophila melanoga...

New page

'''Unreleased structure'''

The entry 5f0g is ON HOLD

Authors: Gonzalez, D., Briand, L., Neiers, F.

Description: Structure of the glutathion transferase delta 2 from drosophila melanogaster
[[Category: Unreleased Structures]]
[[Category: Gonzalez, D]]
[[Category: Neiers, F]]
[[Category: Briand, L]]