5f8z - Revision history

OCA at 06:42, 19 July 2023

OCA — Wed, 19 Jul 2023 06:42:29 GMT

←Older revision		Revision as of 06:42, 19 July 2023
Line 3:		Line 3:
	<StructureSection load='5f8z' size='340' side='right'caption='[[5f8z]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5f8z' size='340' side='right'caption='[[5f8z]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f8z]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zj4 4zj4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5F8Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f8z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zj4 4zj4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F8Z FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MRZ:PIPERIDINE~~-~~1-CARBOXIMIDAMIDE'>MRZ</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:]]</b></td><td class="sblockDat">[[5f8t\|5f8t]], [[5f8x\|5f8x~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>KLKB1, KLK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8z OCA], [https://pdbe.org/5f8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f8z RCSB], [https://www.ebi.ac.uk/pdbsum/5f8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f8z ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Plasma_kallikrein Plasma kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.34 3.4.21.34]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5f8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8z OCA], [~~http~~://pdbe.org/5f8z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5f8z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5f8z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5f8z ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[~~http~~://omim.org/entry/612423 612423]]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.	+	[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[https://omim.org/entry/612423 612423]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.	+	[https://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

	==See Also==		==See Also==
Line 19:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plasma kallikrein~~]]	+	[[Category: Synthetic construct]]
-	[[Category: Andreasen, P]]	+	[[Category: Andreasen P]]
-	[[Category: Huang, M]]	+	[[Category: Huang M]]
-	[[Category: Jiang, L]]	+	[[Category: Jiang L]]
-	[[Category: Luo, Z]]	+	[[Category: Luo Z]]
-	[[Category: Xu, M]]	+	[[Category: Xu M]]
-	[[Category: Xu, P]]	+	[[Category: Xu P]]
-	~~[[Category: Hydrolase-hydrolase inhibitor]]~~	+
-	~~[[Category: Peptide inhibitor~~]]	+

OCA at 08:05, 29 April 2020

OCA — Wed, 29 Apr 2020 08:05:28 GMT

←Older revision		Revision as of 08:05, 29 April 2020
Line 1:		Line 1:

	==The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1==		==The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1==
-	<StructureSection load='5f8z' size='340' side='right' caption='[[5f8z]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='5f8z' size='340' side='right'caption='[[5f8z]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f8z]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zj4 4zj4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8Z OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5F8Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f8z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zj4 4zj4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5F8Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f8t\|5f8t]], [[5f8x\|5f8x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f8t\|5f8t]], [[5f8x\|5f8x]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLKB1, KLK3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasma_kallikrein Plasma kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.34 3.4.21.34] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasma_kallikrein Plasma kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.34 3.4.21.34] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5f8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8z OCA], [http://pdbe.org/5f8z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f8z RCSB], [http://www.ebi.ac.uk/pdbsum/5f8z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f8z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5f8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8z OCA], [http://pdbe.org/5f8z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f8z RCSB], [http://www.ebi.ac.uk/pdbsum/5f8z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f8z ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 13:		Line 14:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.		[[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
		+
		+	==See Also==
		+	*[[Kallikrein 3D structures\|Kallikrein 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Plasma kallikrein]]		[[Category: Plasma kallikrein]]
	[[Category: Andreasen, P]]		[[Category: Andreasen, P]]

OCA at 18:57, 15 December 2016

OCA — Thu, 15 Dec 2016 18:57:26 GMT

←Older revision		Revision as of 18:57, 15 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5f8z is ~~ON HOLD until Paper Publication~~	+	==The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1==
-		+	<StructureSection load='5f8z' size='340' side='right' caption='[[5f8z]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~Authors~~: Xu, M., ~~Jiang~~, L., ~~Xu, P~~., ~~Luo, Z~~., ~~Andreasen, P~~., ~~Huang, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5f8z]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4zj4 4zj4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F8Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F8Z FirstGlance]. <br>
-	~~Description~~: ~~The crystal structure~~ of ~~human Plasma Kallikrein~~ in ~~complex with~~ its ~~peptide inhibitor pkalin~~-1	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MRZ:PIPERIDINE-1-CARBOXIMIDAMIDE'>MRZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f8t\|5f8t]], [[5f8x\|5f8x]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasma_kallikrein Plasma kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.34 3.4.21.34] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f8z OCA], [http://pdbe.org/5f8z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f8z RCSB], [http://www.ebi.ac.uk/pdbsum/5f8z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f8z ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:[http://omim.org/entry/612423 612423]]; also known as Fletcher factor deficiency. This disorder is a blood coagulation defect.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KLKB1_HUMAN KLKB1_HUMAN]] The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Plasma kallikrein]]
	[[Category: Andreasen, P]]		[[Category: Andreasen, P]]
-	[[Category: Xu, P]]
-	[[Category: Xu, M]]
	[[Category: Huang, M]]		[[Category: Huang, M]]
	[[Category: Jiang, L]]		[[Category: Jiang, L]]
	[[Category: Luo, Z]]		[[Category: Luo, Z]]
		+	[[Category: Xu, M]]
		+	[[Category: Xu, P]]
		+	[[Category: Hydrolase-hydrolase inhibitor]]
		+	[[Category: Peptide inhibitor]]

OCA at 00:15, 10 March 2016

OCA — Thu, 10 Mar 2016 00:15:33 GMT

←Older revision		Revision as of 00:15, 10 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5f8z is ON HOLD	+	The entry 5f8z is ON HOLD until Paper Publication

	Authors: Xu, M., Jiang, L., Xu, P., Luo, Z., Andreasen, P., Huang, M.		Authors: Xu, M., Jiang, L., Xu, P., Luo, Z., Andreasen, P., Huang, M.

OCA: Protected "5f8z" [edit=sysop:move=sysop]

OCA — Wed, 16 Dec 2015 12:44:36 GMT

Protected "5f8z" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:44, 16 December 2015

OCA: New page: '''Unreleased structure''' The entry 5f8z is ON HOLD Authors: Xu, M., Jiang, L., Xu, P., Luo, Z., Andreasen, P., Huang, M. Description: The crystal structure of human Plasma Kallikrein...

OCA — Wed, 16 Dec 2015 12:44:34 GMT

New page: '''Unreleased structure''' The entry 5f8z is ON HOLD Authors: Xu, M., Jiang, L., Xu, P., Luo, Z., Andreasen, P., Huang, M. Description: The crystal structure of human Plasma Kallikrein...

New page

'''Unreleased structure'''

The entry 5f8z is ON HOLD

Authors: Xu, M., Jiang, L., Xu, P., Luo, Z., Andreasen, P., Huang, M.

Description: The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1
[[Category: Unreleased Structures]]
[[Category: Andreasen, P]]
[[Category: Xu, P]]
[[Category: Xu, M]]
[[Category: Huang, M]]
[[Category: Jiang, L]]
[[Category: Luo, Z]]