5f9x - Revision history

OCA at 06:43, 19 July 2023

OCA — Wed, 19 Jul 2023 06:43:32 GMT

←Older revision		Revision as of 06:43, 19 July 2023
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	<StructureSection load='5f9x' size='340' side='right'caption='[[5f9x]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='5f9x' size='340' side='right'caption='[[5f9x]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f9x]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F9X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5F9X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F9X FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CPT:CISPLATIN'>CPT</scene~~>, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.94Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5f9u\|5f9u]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f9x OCA], [https://pdbe.org/5f9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f9x RCSB], [https://www.ebi.ac.uk/pdbsum/5f9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f9x ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5f9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f9x OCA], [~~http~~://pdbe.org/5f9x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5f9x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5f9x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5f9x ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>	+	[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Lysozyme]]~~	+	[[Category: Ferraro G]]
-	[[Category: Ferraro, G]]	+	[[Category: Merlino A]]
-	~~[[Category: Krauss, I Russo~~]]	+	[[Category: Pica A]]
-	[[Category: Merlino, A]]	+	[[Category: Russo Krauss I]]
-	[[Category: Pica, A]]	+
-	[[Category: ~~Cisplatin]]~~	+
-	~~[[Category: Drug]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 06:19, 16 October 2019

OCA — Wed, 16 Oct 2019 06:19:22 GMT

←Older revision		Revision as of 06:19, 16 October 2019
Line 1:		Line 1:

	==X-RAY STRUCTURE OF THE ADDUCT BETWEEN HEN EGG WHITE LYSOZYME AND CISPLATIN UPON 24 HOURS OF INCUBATION AT 55 DEGREES==		==X-RAY STRUCTURE OF THE ADDUCT BETWEEN HEN EGG WHITE LYSOZYME AND CISPLATIN UPON 24 HOURS OF INCUBATION AT 55 DEGREES==
-	<StructureSection load='5f9x' size='340' side='right' caption='[[5f9x]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='5f9x' size='340' side='right'caption='[[5f9x]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5f9x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F9X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F9X FirstGlance]. <br>		<table><tr><td colspan='2'>[[5f9x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F9X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F9X FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5f9x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5f9x" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
		+	[[Category: Large Structures]]
	[[Category: Lysozyme]]		[[Category: Lysozyme]]
	[[Category: Ferraro, G]]		[[Category: Ferraro, G]]

OCA at 17:38, 12 July 2016

OCA — Tue, 12 Jul 2016 17:38:27 GMT

←Older revision		Revision as of 17:38, 12 July 2016
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f9u\|5f9u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f9u\|5f9u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f9x OCA], [http://pdbe.org/5f9x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f9x RCSB], [http://www.ebi.ac.uk/pdbsum/5f9x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f9x OCA], [http://pdbe.org/5f9x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f9x RCSB], [http://www.ebi.ac.uk/pdbsum/5f9x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f9x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:26, 12 May 2016

OCA — Thu, 12 May 2016 11:26:54 GMT

←Older revision		Revision as of 11:26, 12 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5f9x is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==X-RAY STRUCTURE OF THE ADDUCT BETWEEN HEN EGG WHITE LYSOZYME AND CISPLATIN UPON 24 HOURS OF INCUBATION AT 55 DEGREES==
		+	<StructureSection load='5f9x' size='340' side='right' caption='[[5f9x]], [[Resolution\|resolution]] 1.94Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5f9x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F9X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F9X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f9u\|5f9u]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f9x OCA], [http://pdbe.org/5f9x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f9x RCSB], [http://www.ebi.ac.uk/pdbsum/5f9x PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The products of the reaction between cisplatin (CDDP) and the model protein hen egg white lysozyme (HEWL) at 20, 37 and 55 degrees C in pure water were studied by UV-Vis absorption spectroscopy, intrinsic fluorescence and circular dichroism, dynamic and electrophoretic light scattering and inductively coupled plasma mass spectrometry. X-ray structures were also solved for the adducts formed at 20 and 55 degrees C. Data demonstrate that high temperature facilitates the formation of CDDP-HEWL adducts, where Pt atoms bind ND1 atom of His15 or NE2 atom of His15 and NH1 atom of Arg14. Our study suggests that high human body temperature (fever) could increase the rate of drug binding to proteins thus enhancing possible toxic side effects related to CDDP administration.

-	~~Authors: Russo Krauss, I~~., Ferraro, G., Pica, A., Merlino, A.	+	Effect of temperature on the interaction of cisplatin with the model protein hen egg white lysozyme.,Ferraro G, Pica A, Russo Krauss I, Pane F, Amoresano A, Merlino A J Biol Inorg Chem. 2016 Apr 4. PMID:27040953<ref>PMID:27040953</ref>

-	~~Description: X~~-~~RAY STRUCTURE OF THE ADDUCT BETWEEN HEN EGG WHITE LYSOZYME AND CISPLATIN UPON 24 HOURS OF INCUBATION AT 55 DEGREES~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5f9x" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gallus gallus]]
		+	[[Category: Lysozyme]]
	[[Category: Ferraro, G]]		[[Category: Ferraro, G]]
		+	[[Category: Krauss, I Russo]]
	[[Category: Merlino, A]]		[[Category: Merlino, A]]
-	[[Category: Russo Krauss, I]]
	[[Category: Pica, A]]		[[Category: Pica, A]]
		+	[[Category: Cisplatin]]
		+	[[Category: Drug]]
		+	[[Category: Hydrolase]]

OCA at 11:20, 23 December 2015

OCA — Wed, 23 Dec 2015 11:20:58 GMT

←Older revision		Revision as of 11:20, 23 December 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5f9x is ON HOLD	+	The entry 5f9x is ON HOLD until Paper Publication

	Authors: Russo Krauss, I., Ferraro, G., Pica, A., Merlino, A.		Authors: Russo Krauss, I., Ferraro, G., Pica, A., Merlino, A.

OCA: Protected "5f9x" [edit=sysop:move=sysop]

OCA — Wed, 16 Dec 2015 12:47:21 GMT

Protected "5f9x" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:47, 16 December 2015

OCA: New page: '''Unreleased structure''' The entry 5f9x is ON HOLD Authors: Russo Krauss, I., Ferraro, G., Pica, A., Merlino, A. Description: X-RAY STRUCTURE OF THE ADDUCT BETWEEN HEN EGG WHITE LYSO...

OCA — Wed, 16 Dec 2015 12:47:20 GMT

New page: '''Unreleased structure''' The entry 5f9x is ON HOLD Authors: Russo Krauss, I., Ferraro, G., Pica, A., Merlino, A. Description: X-RAY STRUCTURE OF THE ADDUCT BETWEEN HEN EGG WHITE LYSO...

New page

'''Unreleased structure'''

The entry 5f9x is ON HOLD

Authors: Russo Krauss, I., Ferraro, G., Pica, A., Merlino, A.

Description: X-RAY STRUCTURE OF THE ADDUCT BETWEEN HEN EGG WHITE LYSOZYME AND CISPLATIN UPON 24 HOURS OF INCUBATION AT 55 DEGREES
[[Category: Unreleased Structures]]
[[Category: Ferraro, G]]
[[Category: Merlino, A]]
[[Category: Russo Krauss, I]]
[[Category: Pica, A]]