5fah - Revision history

OCA at 06:44, 19 July 2023

OCA — Wed, 19 Jul 2023 06:44:02 GMT

←Older revision		Revision as of 06:44, 19 July 2023
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	<StructureSection load='5fah' size='340' side='right'caption='[[5fah]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='5fah' size='340' side='right'caption='[[5fah]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fah]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5VT:(2~{S})-~{N}2-[2-(4-METHOXYPHENYL)ETHYL]-~{N}1-(NAPHTHALEN-1-YLMETHYL)PYRROLIDINE-1,2-DICARBOXAMIDE'>5VT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.1Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLK7, PRSS6, SCCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5VT:(2~{S})-~{N}2-[2-(4-METHOXYPHENYL)ETHYL]-~{N}1-(NAPHTHALEN-1-YLMETHYL)PYRROLIDINE-1,2-DICARBOXAMIDE'>5VT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stratum_corneum_chymotryptic_enzyme Stratum corneum chymotryptic enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.117 3.4.21.117] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fah OCA], [https://pdbe.org/5fah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fah RCSB], [https://www.ebi.ac.uk/pdbsum/5fah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fah ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fah OCA], [~~http~~://pdbe.org/5fah PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fah RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fah PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fah ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN]] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-\|-Cys-7', '16-Tyr-\|-Leu-17', '25-Phe-\|-Tyr-26' and '26-Tyr-\|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.	+	[https://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-\|-Cys-7', '16-Tyr-\|-Leu-17', '25-Phe-\|-Tyr-26' and '26-Tyr-\|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Stratum corneum chymotryptic enzyme]]~~	+	[[Category: Ostermann N]]
-	[[Category: Ostermann, N]]	+	[[Category: Zink F]]
-	[[Category: Zink, F]]	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 08:07, 29 April 2020

OCA — Wed, 29 Apr 2020 08:07:33 GMT

←Older revision		Revision as of 08:07, 29 April 2020
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	==KALLIKREIN-7 IN COMPLEX WITH COMPOUND1==		==KALLIKREIN-7 IN COMPLEX WITH COMPOUND1==
-	<StructureSection load='5fah' size='340' side='right' caption='[[5fah]], [[Resolution\|resolution]] 1.10Å' scene=''>	+	<StructureSection load='5fah' size='340' side='right'caption='[[5fah]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FAH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5VT:(2~{S})-~{N}2-[2-(4-METHOXYPHENYL)ETHYL]-~{N}1-(NAPHTHALEN-1-YLMETHYL)PYRROLIDINE-1,2-DICARBOXAMIDE'>5VT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5VT:(2~{S})-~{N}2-[2-(4-METHOXYPHENYL)ETHYL]-~{N}1-(NAPHTHALEN-1-YLMETHYL)PYRROLIDINE-1,2-DICARBOXAMIDE'>5VT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLK7, PRSS6, SCCE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stratum_corneum_chymotryptic_enzyme Stratum corneum chymotryptic enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.117 3.4.21.117] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stratum_corneum_chymotryptic_enzyme Stratum corneum chymotryptic enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.117 3.4.21.117] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fah OCA], [http://pdbe.org/5fah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fah RCSB], [http://www.ebi.ac.uk/pdbsum/5fah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fah ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fah OCA], [http://pdbe.org/5fah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fah RCSB], [http://www.ebi.ac.uk/pdbsum/5fah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5fah" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fah" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kallikrein 3D structures\|Kallikrein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Stratum corneum chymotryptic enzyme]]		[[Category: Stratum corneum chymotryptic enzyme]]
	[[Category: Ostermann, N]]		[[Category: Ostermann, N]]
	[[Category: Zink, F]]		[[Category: Zink, F]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 11:09, 2 November 2016

OCA — Wed, 02 Nov 2016 11:09:03 GMT

←Older revision		Revision as of 11:09, 2 November 2016
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN]] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-\|-Cys-7', '16-Tyr-\|-Leu-17', '25-Phe-\|-Tyr-26' and '26-Tyr-\|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.		[[http://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN]] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-\|-Cys-7', '16-Tyr-\|-Leu-17', '25-Phe-\|-Tyr-26' and '26-Tyr-\|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Complement is a key component of the innate immune system, recognizing pathogens and promoting their elimination. Complement component 3 (C3) is the central component of the system. Activation of C3 can be initiated by three distinct routes-the classical, the lectin and the alternative pathways-with the alternative pathway also acting as an amplification loop for the other two pathways. The protease factor D (FD) is essential for this amplification process, which, when dysregulated, predisposes individuals to diverse disorders including age-related macular degeneration and paroxysmal nocturnal hemoglobinuria (PNH). Here we describe the identification of potent and selective small-molecule inhibitors of FD. These inhibitors efficiently block alternative pathway (AP) activation and prevent both C3 deposition onto, and lysis of, PNH erythrocytes. Their oral administration inhibited lipopolysaccharide-induced AP activation in FD-humanized mice. These data demonstrate the feasibility of inhibiting the AP with small-molecule antagonists and support the development of FD inhibitors for the treatment of complement-mediated diseases.
		+
		+	Small-molecule factor D inhibitors targeting the alternative complement pathway.,Maibaum J, Liao SM, Vulpetti A, Ostermann N, Randl S, Rudisser S, Lorthiois E, Erbel P, Kinzel B, Kolb FA, Barbieri S, Wagner J, Durand C, Fettis K, Dussauge S, Hughes N, Delgado O, Hommel U, Gould T, Sweeney AM, Gerhartz B, Cumin F, Flohr S, Schubart A, Jaffee B, Harrison R, Risitano AM, Eder J, Anderson K Nat Chem Biol. 2016 Oct 24. doi: 10.1038/nchembio.2208. PMID:27775713<ref>PMID:27775713</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5fah" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:40, 26 October 2016

OCA — Wed, 26 Oct 2016 18:40:41 GMT

←Older revision		Revision as of 18:40, 26 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fah is ~~ON HOLD until Paper Publication~~	+	==KALLIKREIN-7 IN COMPLEX WITH COMPOUND1==
-		+	<StructureSection load='5fah' size='340' side='right' caption='[[5fah]], [[Resolution\|resolution]] 1.10Å' scene=''>
-	~~Authors~~: ~~Ostermann~~, N., ~~Zink~~, F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5fah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FAH FirstGlance]. <br>
-	~~Description~~: ~~KALLIKREIN~~-7 ~~IN COMPLEX WITH COMPOUND1~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5VT:(2~{S})-~{N}2-[2-(4-METHOXYPHENYL)ETHYL]-~{N}1-(NAPHTHALEN-1-YLMETHYL)PYRROLIDINE-1,2-DICARBOXAMIDE'>5VT</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stratum_corneum_chymotryptic_enzyme Stratum corneum chymotryptic enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.117 3.4.21.117] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fah OCA], [http://pdbe.org/5fah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fah RCSB], [http://www.ebi.ac.uk/pdbsum/5fah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fah ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN]] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-\|-Cys-7', '16-Tyr-\|-Leu-17', '25-Phe-\|-Tyr-26' and '26-Tyr-\|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Stratum corneum chymotryptic enzyme]]
	[[Category: Ostermann, N]]		[[Category: Ostermann, N]]
	[[Category: Zink, F]]		[[Category: Zink, F]]
		+	[[Category: Hydrolase]]

OCA: Protected "5fah" [edit=sysop:move=sysop]

OCA — Wed, 23 Dec 2015 11:22:07 GMT

Protected "5fah" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:22, 23 December 2015

OCA: New page: '''Unreleased structure''' The entry 5fah is ON HOLD until Paper Publication Authors: Ostermann, N., Zink, F. Description: KALLIKREIN-7 IN COMPLEX WITH COMPOUND1 [[Category: Unreleased...

OCA — Wed, 23 Dec 2015 11:22:05 GMT

New page: '''Unreleased structure''' The entry 5fah is ON HOLD until Paper Publication Authors: Ostermann, N., Zink, F. Description: KALLIKREIN-7 IN COMPLEX WITH COMPOUND1 [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 5fah is ON HOLD until Paper Publication

Authors: Ostermann, N., Zink, F.

Description: KALLIKREIN-7 IN COMPLEX WITH COMPOUND1
[[Category: Unreleased Structures]]
[[Category: Ostermann, N]]
[[Category: Zink, F]]