5fbj - Revision history

OCA at 06:45, 19 July 2023

OCA — Wed, 19 Jul 2023 06:45:24 GMT

←Older revision		Revision as of 06:45, 19 July 2023
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	<StructureSection load='5fbj' size='340' side='right'caption='[[5fbj]], [[Resolution\|resolution]] 2.42Å' scene=''>		<StructureSection load='5fbj' size='340' side='right'caption='[[5fbj]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fbj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FBJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fbj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FBJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NMM:(2S)-2-AMINO-5-[(N-METHYLCARBAMIMIDOYL)AMINO]PENTANOIC+ACID'>NMM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.42Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qu1\|4qu1]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NMM:(2S)-2-AMINO-5-[(N-METHYLCARBAMIMIDOYL)AMINO]PENTANOIC+ACID'>NMM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KDM8, JMJD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbj OCA], [https://pdbe.org/5fbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fbj RCSB], [https://www.ebi.ac.uk/pdbsum/5fbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbj ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbj OCA], [~~http~~://pdbe.org/5fbj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fbj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fbj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.	+	[https://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.

	==See Also==		==See Also==
Line 17:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu~~, H L~~]]	+	[[Category: Liu HL]]
-	[[Category: Wang, C]]	+	[[Category: Wang C]]
-	[[Category: Wang, Y]]	+	[[Category: Wang Y]]
-	[[Category: Zhang~~, G Y]]~~	+	[[Category: Zhang GY]]
-	~~[[Category: Histone enzyme]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 08:09, 29 April 2020

OCA — Wed, 29 Apr 2020 08:09:11 GMT

←Older revision		Revision as of 08:09, 29 April 2020
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	==Complex structure of JMJD5 and substrate==		==Complex structure of JMJD5 and substrate==
-	<StructureSection load='5fbj' size='340' side='right' caption='[[5fbj]], [[Resolution\|resolution]] 2.42Å' scene=''>	+	<StructureSection load='5fbj' size='340' side='right'caption='[[5fbj]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fbj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FBJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fbj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FBJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NMM:(2S)-2-AMINO-5-[(N-METHYLCARBAMIMIDOYL)AMINO]PENTANOIC+ACID'>NMM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NMM:(2S)-2-AMINO-5-[(N-METHYLCARBAMIMIDOYL)AMINO]PENTANOIC+ACID'>NMM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qu1\|4qu1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qu1\|4qu1]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KDM8, JMJD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbj OCA], [http://pdbe.org/5fbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fbj RCSB], [http://www.ebi.ac.uk/pdbsum/5fbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbj OCA], [http://pdbe.org/5fbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fbj RCSB], [http://www.ebi.ac.uk/pdbsum/5fbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.		[[http://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
		+
		+	==See Also==
		+	*[[Jumonji domain-containing protein 3D structures\|Jumonji domain-containing protein 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Liu, H L]]		[[Category: Liu, H L]]
	[[Category: Wang, C]]		[[Category: Wang, C]]

OCA at 19:14, 15 December 2016

OCA — Thu, 15 Dec 2016 19:14:38 GMT

←Older revision		Revision as of 19:14, 15 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fbj is ~~ON HOLD until Dec~~ 14 ~~2017~~	+	==Complex structure of JMJD5 and substrate==
-		+	<StructureSection load='5fbj' size='340' side='right' caption='[[5fbj]], [[Resolution\|resolution]] 2.42Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5fbj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FBJ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NMM:(2S)-2-AMINO-5-[(N-METHYLCARBAMIMIDOYL)AMINO]PENTANOIC+ACID'>NMM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4qu1\|4qu1]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbj OCA], [http://pdbe.org/5fbj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fbj RCSB], [http://www.ebi.ac.uk/pdbsum/5fbj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fbj ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KDM8_HUMAN KDM8_HUMAN]] Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Liu, H L]]
		+	[[Category: Wang, C]]
		+	[[Category: Wang, Y]]
		+	[[Category: Zhang, G Y]]
		+	[[Category: Histone enzyme]]
		+	[[Category: Oxidoreductase]]

OCA at 12:54, 15 May 2016

OCA — Sun, 15 May 2016 12:54:32 GMT

←Older revision		Revision as of 12:54, 15 May 2016
Line 3:		Line 3:
	The entry 5fbj is ON HOLD until Dec 14 2017		The entry 5fbj is ON HOLD until Dec 14 2017

-	Authors: ~~Liu, H.L., Wang, Y., Wang, C., Zhang, G.Y.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Wang, Y]]
-	[[Category: Zhang, G.Y]]
-	[[Category: Liu, H.L]]
-	[[Category: Wang, C]]

OCA at 15:02, 26 February 2016

OCA — Fri, 26 Feb 2016 15:02:07 GMT

←Older revision		Revision as of 15:02, 26 February 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fbj is ON HOLD	+	The entry 5fbj is ON HOLD until Dec 14 2017

	Authors: Liu, H.L., Wang, Y., Wang, C., Zhang, G.Y.		Authors: Liu, H.L., Wang, Y., Wang, C., Zhang, G.Y.

OCA: Protected "5fbj" [edit=sysop:move=sysop]

OCA — Wed, 23 Dec 2015 11:24:44 GMT

Protected "5fbj" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:24, 23 December 2015

OCA: New page: '''Unreleased structure''' The entry 5fbj is ON HOLD Authors: Liu, H.L., Wang, Y., Wang, C., Zhang, G.Y. Description: Category: Unreleased Structures Category: Wang, Y [[Categ...

OCA — Wed, 23 Dec 2015 11:24:43 GMT

New page: '''Unreleased structure''' The entry 5fbj is ON HOLD Authors: Liu, H.L., Wang, Y., Wang, C., Zhang, G.Y. Description: Category: Unreleased Structures Category: Wang, Y [[Categ...

New page

'''Unreleased structure'''

The entry 5fbj is ON HOLD

Authors: Liu, H.L., Wang, Y., Wang, C., Zhang, G.Y.

Description:
[[Category: Unreleased Structures]]
[[Category: Wang, Y]]
[[Category: Zhang, G.Y]]
[[Category: Liu, H.L]]
[[Category: Wang, C]]