5fcm - Revision history

OCA at 06:46, 19 July 2023

OCA — Wed, 19 Jul 2023 06:46:24 GMT

←Older revision

Revision as of 06:46, 19 July 2023

OCA at 08:11, 29 April 2020

OCA — Wed, 29 Apr 2020 08:11:04 GMT

←Older revision		Revision as of 08:11, 29 April 2020
Line 1:		Line 1:

	==CrBld10-N 1-70==		==CrBld10-N 1-70==
-	<StructureSection load='5fcm' size='340' side='right' caption='[[5fcm]], [[Resolution\|resolution]] 2.23Å' scene=''>	+	<StructureSection load='5fcm' size='340' side='right'caption='[[5fcm]], [[Resolution\|resolution]] 2.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fcm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FCM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FCM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fcm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FCM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FCM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fcm OCA], [http://pdbe.org/5fcm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fcm RCSB], [http://www.ebi.ac.uk/pdbsum/5fcm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fcm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fcm OCA], [http://pdbe.org/5fcm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fcm RCSB], [http://www.ebi.ac.uk/pdbsum/5fcm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fcm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kraatz, S H.W]]		[[Category: Kraatz, S H.W]]
	[[Category: Steinmetz, M O]]		[[Category: Steinmetz, M O]]

OCA at 08:29, 10 August 2016

OCA — Wed, 10 Aug 2016 08:29:11 GMT

←Older revision		Revision as of 08:29, 10 August 2016
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fcm OCA], [http://pdbe.org/5fcm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fcm RCSB], [http://www.ebi.ac.uk/pdbsum/5fcm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fcm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fcm OCA], [http://pdbe.org/5fcm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fcm RCSB], [http://www.ebi.ac.uk/pdbsum/5fcm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fcm ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Centrioles are microtubule-based structures that play important roles notably in cell division and cilium biogenesis. CEP135/Bld10p family members are evolutionarily conserved microtubule-binding proteins important for centriole formation. Here, we analyzed in detail the microtubule-binding activity of human CEP135 (HsCEP135). X-ray crystallography and small-angle X-ray scattering in combination with molecular modeling revealed that the 158 N-terminal residues of HsCEP135 (HsCEP135-N) form a parallel two-stranded coiled-coil structure. Biochemical, cryo-electron, and fluorescence microscopy analyses revealed that in vitro HsCEP135-N interacts with tubulin, protofilaments, and microtubules and induces the formation of microtubule bundles. We further identified a 13 amino acid segment spanning residues 96-108, which represents a major microtubule-binding site in HsCEP135-N. Within this segment, we identified a cluster of three lysine residues that contribute to the microtubule bundling activity of HsCEP135-N. Our results provide the first structural information on CEP135/Bld10p proteins and offer insights into their microtubule-binding mechanism.
		+
		+	The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding.,Kraatz S, Guichard P, Obbineni JM, Olieric N, Hatzopoulos GN, Hilbert M, Sen I, Missimer J, Gonczy P, Steinmetz MO Structure. 2016 Jul 20. pii: S0969-2126(16)30138-1. doi:, 10.1016/j.str.2016.06.011. PMID:27477386<ref>PMID:27477386</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5fcm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:32, 26 July 2016

OCA — Tue, 26 Jul 2016 15:32:20 GMT

←Older revision		Revision as of 15:32, 26 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fcm is ~~ON HOLD until Dec 15 2017~~	+	==CrBld10-N 1-70==
-		+	<StructureSection load='5fcm' size='340' side='right' caption='[[5fcm]], [[Resolution\|resolution]] 2.23Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5fcm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FCM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FCM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fcm OCA], [http://pdbe.org/5fcm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fcm RCSB], [http://www.ebi.ac.uk/pdbsum/5fcm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fcm ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kraatz, S H.W]]
		+	[[Category: Steinmetz, M O]]
		+	[[Category: Bld10]]
		+	[[Category: Cartwheel]]
		+	[[Category: Cell cycle]]
		+	[[Category: Centriole]]
		+	[[Category: Centrosome]]
		+	[[Category: Cep135]]

OCA at 12:55, 15 May 2016

OCA — Sun, 15 May 2016 12:55:19 GMT

←Older revision		Revision as of 12:55, 15 May 2016
Line 3:		Line 3:
	The entry 5fcm is ON HOLD until Dec 15 2017		The entry 5fcm is ON HOLD until Dec 15 2017

-	Authors: ~~Kraatz, S.H.W., Steinmetz, M.O.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Steinmetz, M.O]]
-	[[Category: Kraatz, S.H.W]]

OCA: Protected "5fcm" [edit=sysop:move=sysop]

OCA — Wed, 23 Dec 2015 11:27:43 GMT

Protected "5fcm" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:27, 23 December 2015

OCA: New page: '''Unreleased structure''' The entry 5fcm is ON HOLD until Dec 15 2017 Authors: Kraatz, S.H.W., Steinmetz, M.O. Description: Category: Unreleased Structures [[Category: Steinmetz,...

OCA — Wed, 23 Dec 2015 11:27:42 GMT

New page: '''Unreleased structure''' The entry 5fcm is ON HOLD until Dec 15 2017 Authors: Kraatz, S.H.W., Steinmetz, M.O. Description: Category: Unreleased Structures [[Category: Steinmetz,...

New page

'''Unreleased structure'''

The entry 5fcm is ON HOLD until Dec 15 2017

Authors: Kraatz, S.H.W., Steinmetz, M.O.

Description:
[[Category: Unreleased Structures]]
[[Category: Steinmetz, M.O]]
[[Category: Kraatz, S.H.W]]