5fi8 - Revision history

OCA at 06:52, 19 July 2023

OCA — Wed, 19 Jul 2023 06:52:10 GMT

←Older revision		Revision as of 06:52, 19 July 2023
Line 3:		Line 3:
	<StructureSection load='5fi8' size='340' side='right'caption='[[5fi8]], [[Resolution\|resolution]] 2.32Å' scene=''>		<StructureSection load='5fi8' size='340' side='right'caption='[[5fi8]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fi8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FI8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fi8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FI8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Y5:2-[1,1-BIS(FLUORANYL)ETHYL]-~{N}-[(2~{S})-7-BROMANYL-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL]-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>5Y5</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.32Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFF0160c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5Y5:2-[1,1-BIS(FLUORANYL)ETHYL]-~{N}-[(2~{S})-7-BROMANYL-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL]-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>5Y5</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi8 OCA], [https://pdbe.org/5fi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fi8 RCSB], [https://www.ebi.ac.uk/pdbsum/5fi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fi8 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi8 OCA], [~~http~~://pdbe.org/5fi8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fi8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fi8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fi8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.	+	[https://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plaf7~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Deng, X]]	+	[[Category: Deng X]]
-	[[Category: Kokkonda, S]]	+	[[Category: Kokkonda S]]
-	[[Category: Phillips, M]]	+	[[Category: Phillips M]]
-	[[Category: Tomchick, D]]	+	[[Category: Tomchick D]]
-	~~[[Category: Alpha/beta barrel]]~~	+
-	~~[[Category: Fmn]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Oxidoreductase / oxidoreductase]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 16:10, 11 December 2019

OCA — Wed, 11 Dec 2019 16:10:13 GMT

←Older revision		Revision as of 16:10, 11 December 2019
Line 1:		Line 1:

	==Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidine)==		==Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidine)==
-	<StructureSection load='5fi8' size='340' side='right' caption='[[5fi8]], [[Resolution\|resolution]] 2.32Å' scene=''>	+	<StructureSection load='5fi8' size='340' side='right'caption='[[5fi8]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fi8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FI8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fi8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FI8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Y5:2-[1,1-BIS(FLUORANYL)ETHYL]-~{N}-[(2~{S})-7-BROMANYL-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL]-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>5Y5</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Y5:2-[1,1-BIS(FLUORANYL)ETHYL]-~{N}-[(2~{S})-7-BROMANYL-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL]-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>5Y5</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PFF0160c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi8 OCA], [http://pdbe.org/5fi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fi8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fi8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fi8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi8 OCA], [http://pdbe.org/5fi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fi8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fi8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fi8 ProSAT]</span></td></tr>
Line 21:		Line 22:

	==See Also==		==See Also==
-	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]	+	*[[Dihydroorotate dehydrogenase 3D structures\|Dihydroorotate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Plaf7]]
	[[Category: Deng, X]]		[[Category: Deng, X]]
	[[Category: Kokkonda, S]]		[[Category: Kokkonda, S]]

OCA at 06:52, 6 October 2017

OCA — Fri, 06 Oct 2017 06:52:34 GMT

←Older revision		Revision as of 06:52, 6 October 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5fi8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fi8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydroorotate dehydrogenase\|Dihydroorotate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 02:36, 13 July 2016

OCA — Wed, 13 Jul 2016 02:36:49 GMT

←Older revision		Revision as of 02:36, 13 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Y5:2-[1,1-BIS(FLUORANYL)ETHYL]-~{N}-[(2~{S})-7-BROMANYL-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL]-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>5Y5</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Y5:2-[1,1-BIS(FLUORANYL)ETHYL]-~{N}-[(2~{S})-7-BROMANYL-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL]-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>5Y5</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi8 OCA], [http://pdbe.org/5fi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fi8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fi8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi8 OCA], [http://pdbe.org/5fi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fi8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fi8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fi8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:53, 1 June 2016

OCA — Wed, 01 Jun 2016 15:53:18 GMT

←Older revision		Revision as of 15:53, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fi8 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidine)==
		+	<StructureSection load='5fi8' size='340' side='right' caption='[[5fi8]], [[Resolution\|resolution]] 2.32Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fi8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FI8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Y5:2-[1,1-BIS(FLUORANYL)ETHYL]-~{N}-[(2~{S})-7-BROMANYL-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL]-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE'>5Y5</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fi8 OCA], [http://pdbe.org/5fi8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fi8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fi8 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PYRD_PLAF7 PYRD_PLAF7]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Malaria persists as one of the most devastating global infectious diseases. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) has been identified as a new malaria drug target, and a triazolopyrimidine-based DHODH inhibitor 1 (DSM265) is in clinical development. We sought to identify compounds with higher potency against Plasmodium DHODH while showing greater selectivity toward animal DHODHs. Herein we describe a series of novel triazolopyrimidines wherein the p-SF5-aniline was replaced with substituted 1,2,3,4-tetrahydro-2-naphthyl or 2-indanyl amines. These compounds showed strong species selectivity, and several highly potent tetrahydro-2-naphthyl derivatives were identified. Compounds with halogen substitutions displayed sustained plasma levels after oral dosing in rodents leading to efficacy in the P. falciparum SCID mouse malaria model. These data suggest that tetrahydro-2-naphthyl derivatives have the potential to be efficacious for the treatment of malaria, but due to higher metabolic clearance than 1, they most likely would need to be part of a multidose regimen.

-	~~Authors: Deng, X~~., Kokkonda, S., Tomchick, D., Phillips, M.	+	Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.,Kokkonda S, Deng X, White KL, Coteron JM, Marco M, de Las Heras L, White J, El Mazouni F, Tomchick DR, Manjalanagara K, Rudra KR, Chen G, Morizzi J, Ryan E, Kaminsky W, Leroy D, Martinez-Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Waterson D, Burrows JN, Matthews D, Charman SA, Phillips MA, Rathod PK J Med Chem. 2016 May 21. PMID:27127993<ref>PMID:27127993</ref>

-	~~Description: Crystal structure~~ of ~~plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro~~-2-~~naphthyl and 2-indanyl triazolopyrimidine)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Tomchick, D]]~~	+	<div class="pdbe-citations 5fi8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Deng, X]]		[[Category: Deng, X]]
-	[[Category: Phillips, M]]
	[[Category: Kokkonda, S]]		[[Category: Kokkonda, S]]
		+	[[Category: Phillips, M]]
		+	[[Category: Tomchick, D]]
		+	[[Category: Alpha/beta barrel]]
		+	[[Category: Fmn]]
		+	[[Category: Inhibitor]]
		+	[[Category: Oxidoreductase / oxidoreductase]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 14:39, 20 January 2016

OCA — Wed, 20 Jan 2016 14:39:51 GMT

←Older revision		Revision as of 14:39, 20 January 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fi8 is ON HOLD	+	The entry 5fi8 is ON HOLD until Paper Publication

	Authors: Deng, X., Kokkonda, S., Tomchick, D., Phillips, M.		Authors: Deng, X., Kokkonda, S., Tomchick, D., Phillips, M.

OCA at 18:17, 13 January 2016

OCA — Wed, 13 Jan 2016 18:17:21 GMT

←Older revision		Revision as of 18:17, 13 January 2016
Line 3:		Line 3:
	The entry 5fi8 is ON HOLD		The entry 5fi8 is ON HOLD

-	Authors: Deng, ~~Xiaoyi~~, Kokkonda, ~~Sreekanth~~, Tomchick, ~~Diana~~, Phillips, ~~Margaret~~	+	Authors: Deng, X., Kokkonda, S., Tomchick, D., Phillips, M.

	Description: Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidine)		Description: Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidine)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Deng, ~~Xiaoyi~~, Kokkonda, ~~Sreekanth, Tomchick, Diana, Phillips, Margaret~~]]	+	[[Category: Tomchick, D]]
		+	[[Category: Deng, X]]
		+	[[Category: Phillips, M]]
		+	[[Category: Kokkonda, S]]

OCA: Protected "5fi8" [edit=sysop:move=sysop]

OCA — Wed, 30 Dec 2015 18:00:55 GMT

Protected "5fi8" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:00, 30 December 2015

OCA: New page: '''Unreleased structure''' The entry 5fi8 is ON HOLD Authors: Deng, Xiaoyi, Kokkonda, Sreekanth, Tomchick, Diana, Phillips, Margaret Description: Crystal structure of plasmodium falcip...

OCA — Wed, 30 Dec 2015 18:00:54 GMT

New page: '''Unreleased structure''' The entry 5fi8 is ON HOLD Authors: Deng, Xiaoyi, Kokkonda, Sreekanth, Tomchick, Diana, Phillips, Margaret Description: Crystal structure of plasmodium falcip...

New page

'''Unreleased structure'''

The entry 5fi8 is ON HOLD

Authors: Deng, Xiaoyi, Kokkonda, Sreekanth, Tomchick, Diana, Phillips, Margaret

Description: Crystal structure of plasmodium falciparum dihydroorotate dehydrogenase bounded with DSM422 (Tetrahydro-2-naphthyl and 2-indanyl triazolopyrimidine)
[[Category: Unreleased Structures]]
[[Category: Deng, Xiaoyi, Kokkonda, Sreekanth, Tomchick, Diana, Phillips, Margaret]]