5fka - Revision history

OCA at 06:55, 19 July 2023

OCA — Wed, 19 Jul 2023 06:55:08 GMT

←Older revision		Revision as of 06:55, 19 July 2023
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	<StructureSection load='5fka' size='340' side='right'caption='[[5fka]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5fka' size='340' side='right'caption='[[5fka]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fka]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FKA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fka]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FKA FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5fk9\|5fk9]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ENTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fka OCA], [https://pdbe.org/5fka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fka RCSB], [https://www.ebi.ac.uk/pdbsum/5fka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fka ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fka OCA], [~~http~~://pdbe.org/5fka PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fka RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fka PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fka ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ETXE_STAAU ETXE_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.	+	[https://www.uniprot.org/uniprot/ETXE_STAAU ETXE_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lindkvist-Petersson, K~~]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: ~~Regenthal, P]]~~	+	[[Category: Lindkvist-Petersson K]]
-	~~[[Category: Rodstrom,~~ K ~~E.J~~]]	+	[[Category: Regenthal P]]
-	[[Category: ~~Immune system~~]]	+	[[Category: Rodstrom KEJ]]
-	[[Category: ~~Major histocompatibility complex]]~~	+
-	~~[[Category: Staphylcococcal enterotoxin]]~~	+
-	~~[[Category: Superantigen]]~~	+
-	~~[[Category: T cell receptor~~]]	+

OCA at 07:23, 6 May 2020

OCA — Wed, 06 May 2020 07:23:41 GMT

←Older revision		Revision as of 07:23, 6 May 2020
Line 1:		Line 1:

	==Crystal structure of staphylococcal enterotoxin E in complex with a T cell receptor==		==Crystal structure of staphylococcal enterotoxin E in complex with a T cell receptor==
-	<StructureSection load='5fka' size='340' side='right' caption='[[5fka]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5fka' size='340' side='right'caption='[[5fka]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fka]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FKA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fka]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FKA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fk9\|5fk9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fk9\|5fk9]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fka OCA], [http://pdbe.org/5fka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fka RCSB], [http://www.ebi.ac.uk/pdbsum/5fka PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ENTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fka OCA], [http://pdbe.org/5fka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fka RCSB], [http://www.ebi.ac.uk/pdbsum/5fka PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fka ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5fka" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fka" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[T-cell receptor 3D structures\|T-cell receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Lindkvist-Petersson, K]]		[[Category: Lindkvist-Petersson, K]]
	[[Category: Regenthal, P]]		[[Category: Regenthal, P]]

OCA at 08:31, 1 June 2016

OCA — Wed, 01 Jun 2016 08:31:30 GMT

←Older revision		Revision as of 08:31, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fka is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of staphylococcal enterotoxin E in complex with a T cell receptor==
		+	<StructureSection load='5fka' size='340' side='right' caption='[[5fka]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fka]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FKA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FKA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fk9\|5fk9]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fka OCA], [http://pdbe.org/5fka PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fka RCSB], [http://www.ebi.ac.uk/pdbsum/5fka PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ETXE_STAAU ETXE_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Superantigens are toxins produced by Staphylococcus aureus, called staphylococcal enterotoxins (abbreviated SEA to SEU). They can cross-link the T cell receptor (TCR) and major histocompatibility complex class II, triggering a massive T cell activation and hence disease. Due to high stability and toxicity, superantigens are potential agents of bioterrorism. Hence, antagonists may not only be useful in the treatment of disease but also serve as countermeasures to biological warfare. Of particular interest are inhibitors against SEA and SEB. SEA is the main cause of food poisoning, while SEB is a common toxin manufactured as a biological weapon. Here, we present the crystal structures of SEA in complex with TCR and SEE in complex with the same TCR, complemented with computational alanine-scanning mutagenesis of SEA, SEB, SEC3, SEE, and SEH. We have identified two common areas that contribute to the general TCR binding for these superantigens. This paves the way for design of single antagonists directed towards multiple toxins.

-	~~Authors: Rodstrom, K.E.J~~., ~~Regenthal~~, P., Lindkvist-Petersson, K.	+	Two common structural motifs for TCR recognition by staphylococcal enterotoxins.,Rodstrom KE, Regenthal P, Bahl C, Ford A, Baker D, Lindkvist-Petersson K Sci Rep. 2016 May 16;6:25796. doi: 10.1038/srep25796. PMID:27180909<ref>PMID:27180909</ref>

-	~~Description: Crystal structure of staphylococcal enterotoxin E in complex with~~ a ~~T cell receptor~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5fka" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Lindkvist-Petersson, K]]		[[Category: Lindkvist-Petersson, K]]
-	[[Category: Rodstrom, K.E.J]]
	[[Category: Regenthal, P]]		[[Category: Regenthal, P]]
		+	[[Category: Rodstrom, K E.J]]
		+	[[Category: Immune system]]
		+	[[Category: Major histocompatibility complex]]
		+	[[Category: Staphylcococcal enterotoxin]]
		+	[[Category: Superantigen]]
		+	[[Category: T cell receptor]]

OCA at 22:59, 10 May 2016

OCA — Tue, 10 May 2016 22:59:14 GMT

←Older revision		Revision as of 22:59, 10 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fka is ON HOLD	+	The entry 5fka is ON HOLD until Paper Publication

	Authors: Rodstrom, K.E.J., Regenthal, P., Lindkvist-Petersson, K.		Authors: Rodstrom, K.E.J., Regenthal, P., Lindkvist-Petersson, K.

OCA at 03:30, 1 December 2015

OCA — Tue, 01 Dec 2015 03:30:29 GMT

←Older revision		Revision as of 03:30, 1 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fka is ON HOLD ~~until sometime in the future~~	+	The entry 5fka is ON HOLD

	Authors: Rodstrom, K.E.J., Regenthal, P., Lindkvist-Petersson, K.		Authors: Rodstrom, K.E.J., Regenthal, P., Lindkvist-Petersson, K.

OCA: Protected "5fka" [edit=sysop:move=sysop]

OCA — Thu, 22 Oct 2015 04:40:06 GMT

Protected "5fka" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:40, 22 October 2015

OCA: New page: '''Unreleased structure''' The entry 5fka is ON HOLD until sometime in the future Authors: Rodstrom, K.E.J., Regenthal, P., Lindkvist-Petersson, K. Description: Crystal structure of st...

OCA — Thu, 22 Oct 2015 04:40:04 GMT

New page: '''Unreleased structure''' The entry 5fka is ON HOLD until sometime in the future Authors: Rodstrom, K.E.J., Regenthal, P., Lindkvist-Petersson, K. Description: Crystal structure of st...

New page

'''Unreleased structure'''

The entry 5fka is ON HOLD until sometime in the future

Authors: Rodstrom, K.E.J., Regenthal, P., Lindkvist-Petersson, K.

Description: Crystal structure of staphylococcal enterotoxin E in complex with a T cell receptor
[[Category: Unreleased Structures]]
[[Category: Lindkvist-Petersson, K]]
[[Category: Rodstrom, K.E.J]]
[[Category: Regenthal, P]]