5fm8 - Revision history

OCA at 06:57, 19 July 2023

OCA — Wed, 19 Jul 2023 06:57:02 GMT

←Older revision		Revision as of 06:57, 19 July 2023
Line 3:		Line 3:
	<StructureSection load='5fm8' size='340' side='right'caption='[[5fm8]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='5fm8' size='340' side='right'caption='[[5fm8]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fm8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FM8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FM8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fm8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FM8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fm4\|5fm4]], [[5fm5\|5fm5]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fm8 OCA], [~~http~~://pdbe.org/5fm8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fm8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fm8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fm8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fm8 OCA], [https://pdbe.org/5fm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fm8 RCSB], [https://www.ebi.ac.uk/pdbsum/5fm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fm8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MYOM1_HUMAN MYOM1_HUMAN]] Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.	+	[https://www.uniprot.org/uniprot/MYOM1_HUMAN MYOM1_HUMAN] Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Pernigo, S]]	+	[[Category: Pernigo S]]
-	[[Category: Steiner~~, R A]]~~	+	[[Category: Steiner RA]]
-	~~[[Category: Fibronectin domain]]~~	+
-	~~[[Category: M-band]]~~	+
-	~~[[Category: Sarcomere]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 07:25, 6 May 2020

OCA — Wed, 06 May 2020 07:25:22 GMT

←Older revision		Revision as of 07:25, 6 May 2020
Line 1:		Line 1:

	==Structure of the C-terminally extended domain My4 of human myomesin (space group P65)==		==Structure of the C-terminally extended domain My4 of human myomesin (space group P65)==
-	<StructureSection load='5fm8' size='340' side='right' caption='[[5fm8]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='5fm8' size='340' side='right'caption='[[5fm8]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fm8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FM8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FM8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FM8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FM8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fm4\|5fm4]], [[5fm5\|5fm5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fm4\|5fm4]], [[5fm5\|5fm5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fm8 OCA], [http://pdbe.org/5fm8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fm8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fm8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fm8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fm8 OCA], [http://pdbe.org/5fm8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fm8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fm8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fm8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5fm8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fm8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myomesin\|Myomesin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Pernigo, S]]		[[Category: Pernigo, S]]
	[[Category: Steiner, R A]]		[[Category: Steiner, R A]]

OCA at 09:36, 2 January 2017

OCA — Mon, 02 Jan 2017 09:36:09 GMT

←Older revision		Revision as of 09:36, 2 January 2017
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MYOM1_HUMAN MYOM1_HUMAN]] Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.		[[http://www.uniprot.org/uniprot/MYOM1_HUMAN MYOM1_HUMAN]] Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The sarcomeric cytoskeleton is a network of modular proteins that integrate mechanical and signaling roles. Obscurin, or its homolog obscurin-like-1, bridges the giant ruler titin and the myosin crosslinker myomesin at the M-band. Yet, the molecular mechanisms underlying the physical obscurin(-like-1):myomesin connection, important for mechanical integrity of the M-band, remained elusive. Here, using a combination of structural, cellular, and single-molecule force spectroscopy techniques, we decode the architectural and functional determinants defining the obscurin(-like-1):myomesin complex. The crystal structure reveals a trans-complementation mechanism whereby an incomplete immunoglobulin-like domain assimilates an isoform-specific myomesin interdomain sequence. Crucially, this unconventional architecture provides mechanical stability up to forces of approximately 135 pN. A cellular competition assay in neonatal rat cardiomyocytes validates the complex and provides the rationale for the isoform specificity of the interaction. Altogether, our results reveal a novel binding strategy in sarcomere assembly, which might have implications on muscle nanomechanics and overall M-band organization.
		+
		+	Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.,Pernigo S, Fukuzawa A, Beedle AE, Holt M, Round A, Pandini A, Garcia-Manyes S, Gautel M, Steiner RA Structure. 2016 Dec 15. pii: S0969-2126(16)30357-4. doi:, 10.1016/j.str.2016.11.015. PMID:27989621<ref>PMID:27989621</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5fm8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:50, 10 December 2016

OCA — Sat, 10 Dec 2016 10:50:36 GMT

←Older revision		Revision as of 10:50, 10 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5fm8 is ON HOLD until Paper Publication~~	+	==Structure of the C-terminally extended domain My4 of human myomesin (space group P65)==
-		+	<StructureSection load='5fm8' size='340' side='right' caption='[[5fm8]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~Authors: Pernigo, S., Steiner, R.A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5fm8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FM8 FirstGlance]. <br>
-	~~Description:~~ Structure of the C-terminally extended domain My4 of human myomesin ( space group P65)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fm4\|5fm4]], [[5fm5\|5fm5]]</td></tr>
-	[[~~Category~~: ~~Steiner~~, R.A]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fm8 OCA], [http://pdbe.org/5fm8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fm8 RCSB], [http://www.ebi.ac.uk/pdbsum/5fm8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fm8 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MYOM1_HUMAN MYOM1_HUMAN]] Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
		+	__TOC__
		+	</StructureSection>
	[[Category: Pernigo, S]]		[[Category: Pernigo, S]]
		+	[[Category: Steiner, R A]]
		+	[[Category: Fibronectin domain]]
		+	[[Category: M-band]]
		+	[[Category: Sarcomere]]
		+	[[Category: Structural protein]]

OCA: Protected "5fm8" [edit=sysop:move=sysop]

OCA — Tue, 01 Dec 2015 03:35:23 GMT

Protected "5fm8" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:35, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5fm8 is ON HOLD until Paper Publication Authors: Pernigo, S., Steiner, R.A. Description: Structure of the C-terminally extended domain My4 of human...

OCA — Tue, 01 Dec 2015 03:35:22 GMT

New page: '''Unreleased structure''' The entry 5fm8 is ON HOLD until Paper Publication Authors: Pernigo, S., Steiner, R.A. Description: Structure of the C-terminally extended domain My4 of human...

New page

'''Unreleased structure'''

The entry 5fm8 is ON HOLD until Paper Publication

Authors: Pernigo, S., Steiner, R.A.

Description: Structure of the C-terminally extended domain My4 of human myomesin ( space group P65)
[[Category: Unreleased Structures]]
[[Category: Steiner, R.A]]
[[Category: Pernigo, S]]