5fsg - Revision history

OCA at 13:21, 26 July 2023

OCA — Wed, 26 Jul 2023 13:21:39 GMT

←Older revision		Revision as of 13:21, 26 July 2023
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	<StructureSection load='5fsg' size='340' side='right'caption='[[5fsg]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='5fsg' size='340' side='right'caption='[[5fsg]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fsg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hantv Hantv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FSG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fsg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hantaan_virus_76-118 Hantaan virus 76-118]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FSG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MTT:MALTOTETRAOSE'>MTT</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.209Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRD_900010:alpha-maltotetraose'>PRD_900010</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsg OCA], [~~http~~://pdbe.org/5fsg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fsg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fsg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsg OCA], [https://pdbe.org/5fsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fsg RCSB], [https://www.ebi.ac.uk/pdbsum/5fsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.	+	[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/NCAP_HANTV NCAP_HANTV]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Hantv~~]]	+	[[Category: Hantaan virus 76-118]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Daumke, O]]	+	[[Category: Daumke O]]
-	[[Category: Olal, D]]	+	[[Category: Olal D]]
-	~~[[Category: Encapsidation]]~~	+
-	~~[[Category: Hantavirus]]~~	+
-	~~[[Category: Korean hemorrhagic fever virus]]~~	+
-	~~[[Category: Nucleocapsid]]~~	+
-	~~[[Category: Nucleoprotein]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virus~~]]	+

OCA at 07:35, 23 October 2019

OCA — Wed, 23 Oct 2019 07:35:32 GMT

←Older revision		Revision as of 07:35, 23 October 2019
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	==Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation and a template for drug design==		==Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation and a template for drug design==
-	<StructureSection load='5fsg' size='340' side='right' caption='[[5fsg]], [[Resolution\|resolution]] 3.21Å' scene=''>	+	<StructureSection load='5fsg' size='340' side='right'caption='[[5fsg]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fsg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fsg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hantv Hantv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTT:MALTOTETRAOSE'>MTT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTT:MALTOTETRAOSE'>MTT</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsg OCA], [http://pdbe.org/5fsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsg RCSB], [http://www.ebi.ac.uk/pdbsum/5fsg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsg OCA], [http://pdbe.org/5fsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsg RCSB], [http://www.ebi.ac.uk/pdbsum/5fsg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hantv]]
		+	[[Category: Large Structures]]
	[[Category: Daumke, O]]		[[Category: Daumke, O]]
	[[Category: Olal, D]]		[[Category: Olal, D]]

OCA at 04:09, 12 May 2016

OCA — Thu, 12 May 2016 04:09:13 GMT

←Older revision		Revision as of 04:09, 12 May 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5fsg is ~~ON HOLD until Paper~~ Publication	+	==Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation and a template for drug design==
		+	<StructureSection load='5fsg' size='340' side='right' caption='[[5fsg]], [[Resolution\|resolution]] 3.21Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fsg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MTT:MALTOTETRAOSE'>MTT</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsg OCA], [http://pdbe.org/5fsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsg RCSB], [http://www.ebi.ac.uk/pdbsum/5fsg PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hantaviruses are etiological agents of life-threatening hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. The nucleoprotein (N) of hantavirus is essential for viral transcription and replication, thus representing an attractive target for therapeutic intervention. We have determined the crystal structure of hantavirus N to 3.2 A resolution. The structure reveals a two-lobed, mostly alpha-helical structure that is distantly related to that of orthobunyavirus Ns. A basic RNA binding pocket is located at the intersection between the two lobes. We provide evidence that oligomerization is mediated by amino- and C-terminal arms that bind to the adjacent monomers. Based on these findings, we suggest a model for the oligomeric ribonucleoprotein (RNP) complex. Our structure provides mechanistic insights into RNA encapsidation in the genus Hantavirus and constitutes a template for drug discovery efforts aimed at combating hantavirus infections.

-	~~Authors: Olal~~, D., Daumke, O.	+	Structure of the Hantavirus Nucleoprotein Provides Insights into the Mechanism of RNA Encapsidation.,Olal D, Daumke O Cell Rep. 2016 Mar 8;14(9):2092-9. doi: 10.1016/j.celrep.2016.02.005. Epub 2016, Feb 25. PMID:26923588<ref>PMID:26923588</ref>

-	~~Description: Structure~~ of the ~~hantavirus nucleoprotein provides insights into the mechanism~~ of ~~RNA encapsidation and a template for drug design~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Olal, D]]~~	+	<div class="pdbe-citations 5fsg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Daumke, O]]		[[Category: Daumke, O]]
		+	[[Category: Olal, D]]
		+	[[Category: Encapsidation]]
		+	[[Category: Hantavirus]]
		+	[[Category: Korean hemorrhagic fever virus]]
		+	[[Category: Nucleocapsid]]
		+	[[Category: Nucleoprotein]]
		+	[[Category: Rna]]
		+	[[Category: Viral protein]]
		+	[[Category: Virus]]

OCA at 14:58, 20 January 2016

OCA — Wed, 20 Jan 2016 14:58:22 GMT

←Older revision		Revision as of 14:58, 20 January 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fsg is ON HOLD	+	The entry 5fsg is ON HOLD until Paper Publication

	Authors: Olal, D., Daumke, O.		Authors: Olal, D., Daumke, O.

OCA: Protected "5fsg" [edit=sysop:move=sysop]

OCA — Wed, 13 Jan 2016 18:37:01 GMT

Protected "5fsg" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:37, 13 January 2016

OCA: New page: '''Unreleased structure''' The entry 5fsg is ON HOLD Authors: Olal, D., Daumke, O. Description: Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA en...

OCA — Wed, 13 Jan 2016 18:37:00 GMT

New page: '''Unreleased structure''' The entry 5fsg is ON HOLD Authors: Olal, D., Daumke, O. Description: Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA en...

New page

'''Unreleased structure'''

The entry 5fsg is ON HOLD

Authors: Olal, D., Daumke, O.

Description: Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation and a template for drug design
[[Category: Unreleased Structures]]
[[Category: Olal, D]]
[[Category: Daumke, O]]