5fsu - Revision history

OCA at 13:22, 26 July 2023

OCA — Wed, 26 Jul 2023 13:22:16 GMT

←Older revision		Revision as of 13:22, 26 July 2023
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	<StructureSection load='5fsu' size='340' side='right'caption='[[5fsu]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5fsu' size='340' side='right'caption='[[5fsu]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fsu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trypanosoma_(trypanozoon)_brucei~~ Trypanosoma ~~(trypanozoon)~~ brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fsu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FSU FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5fsv\|5fsv]]~~, [[~~5fsx~~\|~~5fsx]], [[5fsy\|5fsy]], [[5fsz\|5fsz~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsu OCA], [~~http~~://pdbe.org/5fsu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fsu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fsu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsu OCA], [https://pdbe.org/5fsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fsu RCSB], [https://www.ebi.ac.uk/pdbsum/5fsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsu ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C9ZP98_TRYB9 C9ZP98_TRYB9]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Haikarainen, T~~]]	+	[[Category: Trypanosoma brucei]]
-	[[Category: ~~Lehtio, L~~]]	+	[[Category: Haikarainen T]]
-	[[Category: ~~Adp-ribose binding]]~~	+	[[Category: Lehtio L]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Macrodomain~~]]	+

OCA at 07:35, 6 May 2020

OCA — Wed, 06 May 2020 07:35:14 GMT

←Older revision		Revision as of 07:35, 6 May 2020
Line 1:		Line 1:

	==Crystal structure of Trypanosoma brucei macrodomain (crystal form 1)==		==Crystal structure of Trypanosoma brucei macrodomain (crystal form 1)==
-	<StructureSection load='5fsu' size='340' side='right' caption='[[5fsu]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='5fsu' size='340' side='right'caption='[[5fsu]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FSU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fsv\|5fsv]], [[5fsx\|5fsx]], [[5fsy\|5fsy]], [[5fsz\|5fsz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fsv\|5fsv]], [[5fsx\|5fsx]], [[5fsy\|5fsy]], [[5fsz\|5fsz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsu OCA], [http://pdbe.org/5fsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsu RCSB], [http://www.ebi.ac.uk/pdbsum/5fsu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsu OCA], [http://pdbe.org/5fsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsu RCSB], [http://www.ebi.ac.uk/pdbsum/5fsu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Haikarainen, T]]		[[Category: Haikarainen, T]]
	[[Category: Lehtio, L]]		[[Category: Lehtio, L]]

OCA at 12:36, 16 November 2017

OCA — Thu, 16 Nov 2017 12:36:20 GMT

←Older revision		Revision as of 12:36, 16 November 2017
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	<StructureSection load='5fsu' size='340' side='right' caption='[[5fsu]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5fsu' size='340' side='right' caption='[[5fsu]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fsu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_(trypanozoon)_brucei Trypanosoma (trypanozoon) brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fsv\|5fsv]], [[5fsx\|5fsx]], [[5fsy\|5fsy]], [[5fsz\|5fsz]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fsv\|5fsv]], [[5fsx\|5fsx]], [[5fsy\|5fsy]], [[5fsz\|5fsz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsu OCA], [http://pdbe.org/5fsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsu RCSB], [http://www.ebi.ac.uk/pdbsum/5fsu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsu OCA], [http://pdbe.org/5fsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsu RCSB], [http://www.ebi.ac.uk/pdbsum/5fsu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:45, 12 May 2016

OCA — Thu, 12 May 2016 18:45:03 GMT

←Older revision		Revision as of 18:45, 12 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fsu is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Trypanosoma brucei macrodomain (crystal form 1)==
		+	<StructureSection load='5fsu' size='340' side='right' caption='[[5fsu]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fsu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSU FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fsv\|5fsv]], [[5fsx\|5fsx]], [[5fsy\|5fsy]], [[5fsz\|5fsz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsu OCA], [http://pdbe.org/5fsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsu RCSB], [http://www.ebi.ac.uk/pdbsum/5fsu PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ADP-ribosylation is a ubiquitous protein modification utilized by both prokaryotes and eukaryotes for several cellular functions, such as DNA repair, proliferation, and cell signaling. Higher eukaryotes, such as humans, utilize various enzymes to reverse the modification and to regulate ADP-ribose dependent signaling. In contrast, some lower eukaryotes, including trypanosomatids, lack many of these enzymes and therefore have a much more simplified ADP-ribose metabolism. Here we identified and characterized ADP-ribose hydrolases from Trypanosoma brucei and Trypanosoma cruzi, which are homologous to human O-acetyl-ADP-ribose deacetylases MacroD1 and MacroD2. The enzymes are capable for hydrolysis of protein linked ADP-ribose and a product of sirtuin-mediated lysine deacetylation, O-acetyl-ADP-ribose. Crystal structures of the trypanosomatid macrodomains revealed a conserved catalytic site with distinct differences to human MacroD1 and MacroD2.

-	~~Authors: Haikarainen~~, T., Lehtio, L.	+	Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.,Haikarainen T, Lehtio L Sci Rep. 2016 Apr 11;6:24213. doi: 10.1038/srep24213. PMID:27064071<ref>PMID:27064071</ref>

-	~~Description: Crystal structure~~ of ~~Trypanosoma brucei macrodomain (crystal form 1)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Lehtio, L]]~~	+	<div class="pdbe-citations 5fsu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Haikarainen, T]]		[[Category: Haikarainen, T]]
		+	[[Category: Lehtio, L]]
		+	[[Category: Adp-ribose binding]]
		+	[[Category: Hydrolase]]
		+	[[Category: Macrodomain]]

OCA: Protected "5fsu" [edit=sysop:move=sysop]

OCA — Wed, 20 Jan 2016 14:59:44 GMT

Protected "5fsu" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:59, 20 January 2016

OCA: New page: '''Unreleased structure''' The entry 5fsu is ON HOLD until Paper Publication Authors: Haikarainen, T., Lehtio, L. Description: Crystal structure of Trypanosoma brucei macrodomain (crys...

OCA — Wed, 20 Jan 2016 14:59:42 GMT

New page: '''Unreleased structure''' The entry 5fsu is ON HOLD until Paper Publication Authors: Haikarainen, T., Lehtio, L. Description: Crystal structure of Trypanosoma brucei macrodomain (crys...

New page

'''Unreleased structure'''

The entry 5fsu is ON HOLD until Paper Publication

Authors: Haikarainen, T., Lehtio, L.

Description: Crystal structure of Trypanosoma brucei macrodomain (crystal form 1)
[[Category: Unreleased Structures]]
[[Category: Lehtio, L]]
[[Category: Haikarainen, T]]