5fsz - Revision history

OCA at 13:22, 26 July 2023

OCA — Wed, 26 Jul 2023 13:22:25 GMT

←Older revision		Revision as of 13:22, 26 July 2023
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	<StructureSection load='5fsz' size='340' side='right'caption='[[5fsz]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5fsz' size='340' side='right'caption='[[5fsz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fsz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FSZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FSZ FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5fsu\|5fsu]], [[5fsv\|5fsv]], [[5fsx\|5fsx]]~~, [[~~5fsy~~\|~~5fsy~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsz OCA], [~~http~~://pdbe.org/5fsz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fsz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fsz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsz OCA], [https://pdbe.org/5fsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fsz RCSB], [https://www.ebi.ac.uk/pdbsum/5fsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q4DQ03_TRYCC Q4DQ03_TRYCC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Haikarainen, T~~]]	+	[[Category: Trypanosoma cruzi]]
-	[[Category: ~~Lehtio, L~~]]	+	[[Category: Haikarainen T]]
-	[[Category: ~~Adp-ribose binding]]~~	+	[[Category: Lehtio L]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Macrodomain~~]]	+

OCA at 07:35, 6 May 2020

OCA — Wed, 06 May 2020 07:35:20 GMT

←Older revision		Revision as of 07:35, 6 May 2020
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	==Crystal structure of Trypanosoma cruzi macrodomain==		==Crystal structure of Trypanosoma cruzi macrodomain==
-	<StructureSection load='5fsz' size='340' side='right' caption='[[5fsz]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5fsz' size='340' side='right'caption='[[5fsz]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fsz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FSZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fsz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FSZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fsu\|5fsu]], [[5fsv\|5fsv]], [[5fsx\|5fsx]], [[5fsy\|5fsy]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fsu\|5fsu]], [[5fsv\|5fsv]], [[5fsx\|5fsx]], [[5fsy\|5fsy]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsz OCA], [http://pdbe.org/5fsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsz RCSB], [http://www.ebi.ac.uk/pdbsum/5fsz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsz OCA], [http://pdbe.org/5fsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsz RCSB], [http://www.ebi.ac.uk/pdbsum/5fsz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Haikarainen, T]]		[[Category: Haikarainen, T]]
	[[Category: Lehtio, L]]		[[Category: Lehtio, L]]

OCA at 10:30, 13 September 2017

OCA — Wed, 13 Sep 2017 10:30:23 GMT

←Older revision		Revision as of 10:30, 13 September 2017
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	<table><tr><td colspan='2'>[[5fsz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fsz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fsu\|5fsu]], [[5fsv\|5fsv]], [[5fsx\|5fsx]], [[5fsy\|5fsy]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fsu\|5fsu]], [[5fsv\|5fsv]], [[5fsx\|5fsx]], [[5fsy\|5fsy]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsz OCA], [http://pdbe.org/5fsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsz RCSB], [http://www.ebi.ac.uk/pdbsum/5fsz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsz OCA], [http://pdbe.org/5fsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsz RCSB], [http://www.ebi.ac.uk/pdbsum/5fsz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:45, 12 May 2016

OCA — Thu, 12 May 2016 18:45:18 GMT

←Older revision		Revision as of 18:45, 12 May 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5fsz is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Trypanosoma cruzi macrodomain==
		+	<StructureSection load='5fsz' size='340' side='right' caption='[[5fsz]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fsz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSZ FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fsu\|5fsu]], [[5fsv\|5fsv]], [[5fsx\|5fsx]], [[5fsy\|5fsy]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsz OCA], [http://pdbe.org/5fsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsz RCSB], [http://www.ebi.ac.uk/pdbsum/5fsz PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ADP-ribosylation is a ubiquitous protein modification utilized by both prokaryotes and eukaryotes for several cellular functions, such as DNA repair, proliferation, and cell signaling. Higher eukaryotes, such as humans, utilize various enzymes to reverse the modification and to regulate ADP-ribose dependent signaling. In contrast, some lower eukaryotes, including trypanosomatids, lack many of these enzymes and therefore have a much more simplified ADP-ribose metabolism. Here we identified and characterized ADP-ribose hydrolases from Trypanosoma brucei and Trypanosoma cruzi, which are homologous to human O-acetyl-ADP-ribose deacetylases MacroD1 and MacroD2. The enzymes are capable for hydrolysis of protein linked ADP-ribose and a product of sirtuin-mediated lysine deacetylation, O-acetyl-ADP-ribose. Crystal structures of the trypanosomatid macrodomains revealed a conserved catalytic site with distinct differences to human MacroD1 and MacroD2.

-	~~Authors: Haikarainen~~, T., Lehtio, L.	+	Proximal ADP-ribose Hydrolysis in Trypanosomatids is Catalyzed by a Macrodomain.,Haikarainen T, Lehtio L Sci Rep. 2016 Apr 11;6:24213. doi: 10.1038/srep24213. PMID:27064071<ref>PMID:27064071</ref>

-	~~Description: Crystal structure~~ of ~~Trypanosoma cruzi macrodomain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Lehtio, L]]~~	+	<div class="pdbe-citations 5fsz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Haikarainen, T]]		[[Category: Haikarainen, T]]
		+	[[Category: Lehtio, L]]
		+	[[Category: Adp-ribose binding]]
		+	[[Category: Hydrolase]]
		+	[[Category: Macrodomain]]

OCA: Protected "5fsz" [edit=sysop:move=sysop]

OCA — Wed, 20 Jan 2016 14:59:58 GMT

Protected "5fsz" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:59, 20 January 2016

OCA: New page: '''Unreleased structure''' The entry 5fsz is ON HOLD until Paper Publication Authors: Haikarainen, T., Lehtio, L. Description: Crystal structure of Trypanosoma cruzi macrodomain [[Cate...

OCA — Wed, 20 Jan 2016 14:59:56 GMT

New page: '''Unreleased structure''' The entry 5fsz is ON HOLD until Paper Publication Authors: Haikarainen, T., Lehtio, L. Description: Crystal structure of Trypanosoma cruzi macrodomain [[Cate...

New page

'''Unreleased structure'''

The entry 5fsz is ON HOLD until Paper Publication

Authors: Haikarainen, T., Lehtio, L.

Description: Crystal structure of Trypanosoma cruzi macrodomain
[[Category: Unreleased Structures]]
[[Category: Lehtio, L]]
[[Category: Haikarainen, T]]