5ftg - Revision history

OCA at 13:24, 26 July 2023

OCA — Wed, 26 Jul 2023 13:24:11 GMT

←Older revision		Revision as of 13:24, 26 July 2023
Line 3:		Line 3:
	<StructureSection load='5ftg' size='340' side='right'caption='[[5ftg]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='5ftg' size='340' side='right'caption='[[5ftg]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ftg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FTG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FTG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ftg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FTG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NBR:1-[[4-[2-[4-[[4-(DIMETHYLAMINO)PYRIDIN-1-YL]METHYL]PHENOXY]ETHOXY]PHENYL]METHYL]-N,N-DIMETHYL-PYRIDIN-4-AMINE'>NBR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ftg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ftg OCA], [~~http~~://pdbe.org/5ftg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ftg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ftg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ftg ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NBR:1-[[4-[2-[4-[[4-(DIMETHYLAMINO)PYRIDIN-1-YL]METHYL]PHENOXY]ETHOXY]PHENYL]METHYL]-N,N-DIMETHYL-PYRIDIN-4-AMINE'>NBR</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ftg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ftg OCA], [https://pdbe.org/5ftg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ftg RCSB], [https://www.ebi.ac.uk/pdbsum/5ftg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ftg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN]] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>	+	[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baglioni, E]]	+	[[Category: Baglioni E]]
-	[[Category: Basso, G]]	+	[[Category: Basso G]]
-	[[Category: Bortolozzi, R]]	+	[[Category: Bortolozzi R]]
-	[[Category: Carrasco-Jimenez~~, M P~~]]	+	[[Category: Carrasco-Jimenez MP]]
-	[[Category: Entrena, A]]	+	[[Category: Entrena A]]
-	[[Category: Gallo~~, M A~~]]	+	[[Category: Gallo MA]]
-	[[Category: Hurtado-Guerrero, R]]	+	[[Category: Hurtado-Guerrero R]]
-	[[Category: Lopez-Cara~~, L C~~]]	+	[[Category: Lopez-Cara LC]]
-	[[Category: Marco, C]]	+	[[Category: Marco C]]
-	[[Category: Mariotto, E]]	+	[[Category: Mariotto E]]
-	[[Category: Rios-Marco, P]]	+	[[Category: Rios-Marco P]]
-	[[Category: Schiaffino-Ortega, S]]	+	[[Category: Schiaffino-Ortega S]]
-	[[Category: Serran-Aguilera, L]]	+	[[Category: Serran-Aguilera L]]
-	[[Category: Viola, G]]	+	[[Category: Viola G]]
-	~~[[Category: Biscationic inhibitor]]~~	+
-	~~[[Category: Docking study]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:35, 23 October 2019

OCA — Wed, 23 Oct 2019 07:35:49 GMT

←Older revision		Revision as of 07:35, 23 October 2019
Line 1:		Line 1:

	==Human choline kinase a1 in complex with compound 1-[[4-[2-[4-[[4-(dimethylamino)pyridin-1- yl]methyl]phenoxy]ethoxy]phenyl]methyl]-N,N- dimethyl-pyridin-4-amine (compound 10a)==		==Human choline kinase a1 in complex with compound 1-[[4-[2-[4-[[4-(dimethylamino)pyridin-1- yl]methyl]phenoxy]ethoxy]phenyl]methyl]-N,N- dimethyl-pyridin-4-amine (compound 10a)==
-	<StructureSection load='5ftg' size='340' side='right' caption='[[5ftg]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='5ftg' size='340' side='right'caption='[[5ftg]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ftg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FTG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ftg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FTG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NBR:1-[[4-[2-[4-[[4-(DIMETHYLAMINO)PYRIDIN-1-YL]METHYL]PHENOXY]ETHOXY]PHENYL]METHYL]-N,N-DIMETHYL-PYRIDIN-4-AMINE'>NBR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NBR:1-[[4-[2-[4-[[4-(DIMETHYLAMINO)PYRIDIN-1-YL]METHYL]PHENOXY]ETHOXY]PHENYL]METHYL]-N,N-DIMETHYL-PYRIDIN-4-AMINE'>NBR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ftg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ftg OCA], [http://pdbe.org/5ftg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ftg RCSB], [http://www.ebi.ac.uk/pdbsum/5ftg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ftg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ftg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ftg OCA], [http://pdbe.org/5ftg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ftg RCSB], [http://www.ebi.ac.uk/pdbsum/5ftg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ftg ProSAT]</span></td></tr>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5ftg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ftg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Choline kinase 3D structures\|Choline kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Baglioni, E]]		[[Category: Baglioni, E]]
	[[Category: Basso, G]]		[[Category: Basso, G]]

OCA at 19:37, 9 December 2016

OCA — Fri, 09 Dec 2016 19:37:31 GMT

←Older revision		Revision as of 19:37, 9 December 2016
Line 1:		Line 1:

-	==~~Design, synthesis~~, ~~crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase alpha1~~ (~~ChoKalpha1~~)==	+	==Human choline kinase a1 in complex with compound 1-[[4-[2-[4-[[4-(dimethylamino)pyridin-1- yl]methyl]phenoxy]ethoxy]phenyl]methyl]-N,N- dimethyl-pyridin-4-amine (compound 10a)==
	<StructureSection load='5ftg' size='340' side='right' caption='[[5ftg]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='5ftg' size='340' side='right' caption='[[5ftg]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ftg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FTG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ftg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FTG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NBR:1-[[4-[2-[4-[[4-(DIMETHYLAMINO)PYRIDIN-1-YL]METHYL]PHENOXY]ETHOXY]PHENYL]METHYL]-N,N-DIMETHYL-PYRIDIN-4-AMINE'>NBR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NBR:1-[[4-[2-[4-[[4-(DIMETHYLAMINO)PYRIDIN-1-YL]METHYL]PHENOXY]ETHOXY]PHENYL]METHYL]-N,N-DIMETHYL-PYRIDIN-4-AMINE'>NBR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ftg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ftg OCA], [http://pdbe.org/5ftg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ftg RCSB], [http://www.ebi.ac.uk/pdbsum/5ftg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ftg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ftg OCA], [http://pdbe.org/5ftg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ftg RCSB], [http://www.ebi.ac.uk/pdbsum/5ftg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ftg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:26, 10 May 2016

OCA — Tue, 10 May 2016 17:26:36 GMT

←Older revision		Revision as of 17:26, 10 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ftg is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase alpha1 (ChoKalpha1)==
		+	<StructureSection load='5ftg' size='340' side='right' caption='[[5ftg]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ftg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FTG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NBR:1-[[4-[2-[4-[[4-(DIMETHYLAMINO)PYRIDIN-1-YL]METHYL]PHENOXY]ETHOXY]PHENYL]METHYL]-N,N-DIMETHYL-PYRIDIN-4-AMINE'>NBR</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ftg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ftg OCA], [http://pdbe.org/5ftg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ftg RCSB], [http://www.ebi.ac.uk/pdbsum/5ftg PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN]] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A novel family of compounds derivative of 1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bispyridinium or -bisquinolinium bromide (10a-l) containing a pair of oxygen atoms in the spacer of the linker between the biscationic moieties, were synthesized and evaluated as inhibitors of choline kinase against a panel of cancer-cell lines. The most promising compounds in this series were 1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethyl amino)pyridinium) bromide (10a) and 1,1'-(((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))-bis(7-chloro-4 -(pyrrolidin-1-yl)quinolinium) bromide (10l), which inhibit human choline kinase (ChoKalpha1) with IC50 of 1.0 and 0.92 muM, respectively, in a range similar to that of the previously reported biscationic compounds MN58b and RSM932A. Our compounds show greater antiproliferative activities than do the reference compounds, with unprecedented values of GI50 in the nanomolar range for several of the cancer-cell lines assayed, and more importantly they present low toxicity in non-tumoral cell lines, suggesting a cancer-cell-selective antiproliferative activity. Docking studies predict that the compounds interact with the choline-binding site in agreement with the binding mode of most previously reported biscationic compounds. Moreover, the crystal structure of ChoKalpha1 with compound 10a reveals that this compound binds to the choline-binding site and mimics HC-3 binding mode as never before.

-	~~Authors:~~ Schiaffino-Ortega, S., Baglioni, E., Mariotto, E., Bortolozzi, R., Serran-Aguilera, L., Rios-Marco, P., Carrasco-Jimenez~~, M.P.~~, Gallo~~, M.A.~~, Hurtado-Guerrero, R., Marco, C., Basso, G., Viola, G., Entrena, A., Lopez-Cara~~, L~~.C.	+	Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase alpha1 (ChoKalpha1).,Schiaffino-Ortega S, Baglioni E, Mariotto E, Bortolozzi R, Serran-Aguilera L, Rios-Marco P, Carrasco-Jimenez MP, Gallo MA, Hurtado-Guerrero R, Marco C, Basso G, Viola G, Entrena A, Lopez-Cara LC Sci Rep. 2016 Mar 31;6:23793. doi: 10.1038/srep23793. PMID:27029499<ref>PMID:27029499</ref>

-	~~Description: Design, synthesis~~, ~~crystallization and biological evaluation~~ of ~~new symmetrical biscationic compounds as selective inhibitors~~ of ~~human Choline Kinase alpha1 (ChoKalpha1)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Carrasco~~-~~Jimenez, M.P]]~~	+	<div class="pdbe-citations 5ftg" style="background-color:#fffaf0;"></div>
-	~~[[Category: Lopez~~-~~Cara, L.C]]~~	+	== References ==
-	~~[[Category~~: ~~Entrena, A]]~~	+	<references/>
-	~~[[Category: Basso, G]]~~	+	__TOC__
-	~~[[Category: Rios-Marco, P]]~~	+	</StructureSection>
-	~~[[Category: Gallo, M.A]]~~	+
-	~~[[Category: Serran-Aguilera, L]]~~	+
	[[Category: Baglioni, E]]		[[Category: Baglioni, E]]
-	[[Category: ~~Viola~~, G]]	+	[[Category: Basso, G]]
-	~~[[Category: Hurtado-Guerrero, R~~]]	+
	[[Category: Bortolozzi, R]]		[[Category: Bortolozzi, R]]
		+	[[Category: Carrasco-Jimenez, M P]]
		+	[[Category: Entrena, A]]
		+	[[Category: Gallo, M A]]
		+	[[Category: Hurtado-Guerrero, R]]
		+	[[Category: Lopez-Cara, L C]]
	[[Category: Marco, C]]		[[Category: Marco, C]]
	[[Category: Mariotto, E]]		[[Category: Mariotto, E]]
		+	[[Category: Rios-Marco, P]]
	[[Category: Schiaffino-Ortega, S]]		[[Category: Schiaffino-Ortega, S]]
		+	[[Category: Serran-Aguilera, L]]
		+	[[Category: Viola, G]]
		+	[[Category: Biscationic inhibitor]]
		+	[[Category: Docking study]]
		+	[[Category: Transferase]]

OCA at 00:21, 28 January 2016

OCA — Thu, 28 Jan 2016 00:21:03 GMT

←Older revision		Revision as of 00:21, 28 January 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ftg is ON HOLD	+	The entry 5ftg is ON HOLD until Paper Publication

	Authors: Schiaffino-Ortega, S., Baglioni, E., Mariotto, E., Bortolozzi, R., Serran-Aguilera, L., Rios-Marco, P., Carrasco-Jimenez, M.P., Gallo, M.A., Hurtado-Guerrero, R., Marco, C., Basso, G., Viola, G., Entrena, A., Lopez-Cara, L.C.		Authors: Schiaffino-Ortega, S., Baglioni, E., Mariotto, E., Bortolozzi, R., Serran-Aguilera, L., Rios-Marco, P., Carrasco-Jimenez, M.P., Gallo, M.A., Hurtado-Guerrero, R., Marco, C., Basso, G., Viola, G., Entrena, A., Lopez-Cara, L.C.

OCA: Protected "5ftg" [edit=sysop:move=sysop]

OCA — Wed, 20 Jan 2016 15:03:02 GMT

Protected "5ftg" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:03, 20 January 2016

OCA: New page: '''Unreleased structure''' The entry 5ftg is ON HOLD Authors: Schiaffino-Ortega, S., Baglioni, E., Mariotto, E., Bortolozzi, R., Serran-Aguilera, L., Rios-Marco, P., Carrasco-Jimenez, M...

OCA — Wed, 20 Jan 2016 15:03:00 GMT

New page: '''Unreleased structure''' The entry 5ftg is ON HOLD Authors: Schiaffino-Ortega, S., Baglioni, E., Mariotto, E., Bortolozzi, R., Serran-Aguilera, L., Rios-Marco, P., Carrasco-Jimenez, M...

New page

'''Unreleased structure'''

The entry 5ftg is ON HOLD

Authors: Schiaffino-Ortega, S., Baglioni, E., Mariotto, E., Bortolozzi, R., Serran-Aguilera, L., Rios-Marco, P., Carrasco-Jimenez, M.P., Gallo, M.A., Hurtado-Guerrero, R., Marco, C., Basso, G., Viola, G., Entrena, A., Lopez-Cara, L.C.

Description: Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase alpha1 (ChoKalpha1)
[[Category: Unreleased Structures]]
[[Category: Carrasco-Jimenez, M.P]]
[[Category: Lopez-Cara, L.C]]
[[Category: Entrena, A]]
[[Category: Basso, G]]
[[Category: Rios-Marco, P]]
[[Category: Gallo, M.A]]
[[Category: Serran-Aguilera, L]]
[[Category: Baglioni, E]]
[[Category: Viola, G]]
[[Category: Hurtado-Guerrero, R]]
[[Category: Bortolozzi, R]]
[[Category: Marco, C]]
[[Category: Mariotto, E]]
[[Category: Schiaffino-Ortega, S]]