5fur - Revision history

OCA at 13:27, 26 July 2023

OCA — Wed, 26 Jul 2023 13:27:29 GMT

←Older revision		Revision as of 13:27, 26 July 2023
Line 3:		Line 3:
	<SX load='5fur' size='340' side='right' viewer='molstar' caption='[[5fur]], [[Resolution\|resolution]] 8.50Å' scene=''>		<SX load='5fur' size='340' side='right' viewer='molstar' caption='[[5fur]], [[Resolution\|resolution]] 8.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fur]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FUR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fur]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FUR FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 8.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fur OCA], [~~http~~://pdbe.org/5fur PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fur RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fur PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fur ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fur OCA], [https://pdbe.org/5fur PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fur RCSB], [https://www.ebi.ac.uk/pdbsum/5fur PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fur ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[http://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN]] Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:[http://omim.org/entry/314250 314250]]; also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.<ref>PMID:12928496</ref> <ref>PMID:17273961</ref> [[http://www.uniprot.org/uniprot/TAF2_HUMAN TAF2_HUMAN]] Microcephaly-thin corpus callosum-intellectual disability syndrome. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/TBP_HUMAN TBP_HUMAN]] Defects in TBP are the cause of spinocerebellar ataxia type 17 (SCA17) [MIM:[~~http~~://omim.org/entry/607136 607136]]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA17 is an autosomal dominant cerebellar ataxia (ADCA) characterized by widespread cerebral and cerebellar atrophy, dementia and extrapyramidal signs. The molecular defect in SCA17 is the expansion of a CAG repeat in the coding region of TBP. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.<ref>PMID:11313753</ref> <ref>PMID:11448935</ref> <ref>PMID:11939898</ref>	+	[https://www.uniprot.org/uniprot/TBP_HUMAN TBP_HUMAN] Defects in TBP are the cause of spinocerebellar ataxia type 17 (SCA17) [MIM:[https://omim.org/entry/607136 607136]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA17 is an autosomal dominant cerebellar ataxia (ADCA) characterized by widespread cerebral and cerebellar atrophy, dementia and extrapyramidal signs. The molecular defect in SCA17 is the expansion of a CAG repeat in the coding region of TBP. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.<ref>PMID:11313753</ref> <ref>PMID:11448935</ref> <ref>PMID:11939898</ref>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/TAF8_HUMAN TAF8_HUMAN]] Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). [[http://www.uniprot.org/uniprot/TF2AA_HUMAN TF2AA_HUMAN]] TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.<ref>PMID:11030333</ref> <ref>PMID:16537915</ref> [[http://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN]] Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.<ref>PMID:2038334</ref> <ref>PMID:8450888</ref> <ref>PMID:8625415</ref> <ref>PMID:9660973</ref> <ref>PMID:9858607</ref> <ref>PMID:11278496</ref> <ref>PMID:15053879</ref> [[http://www.uniprot.org/uniprot/TAF2_HUMAN TAF2_HUMAN]] Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.<ref>PMID:9418870</ref> <ref>PMID:9774672</ref> [[http://www.uniprot.org/uniprot/TAF7_HUMAN TAF7_HUMAN]] Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). [[http://www.uniprot.org/uniprot/TBP_HUMAN TBP_HUMAN]] General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.<ref>PMID:15970593</ref> [[http://www.uniprot.org/uniprot/T2AG_HUMAN T2AG_HUMAN]] TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.<ref>PMID:11030333</ref> [[http://www.uniprot.org/uniprot/TAF6_HUMAN TAF6_HUMAN]] TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.	+	[https://www.uniprot.org/uniprot/TBP_HUMAN TBP_HUMAN] General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.<ref>PMID:15970593</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 30:		Line 31:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chacon, P]]	+	[[Category: Chacon P]]
-	[[Category: Fang, J]]	+	[[Category: Fang J]]
-	[[Category: He, Y]]	+	[[Category: He Y]]
-	[[Category: Lopez-Blanco~~, J R~~]]	+	[[Category: Lopez-Blanco JR]]
-	[[Category: Louder~~, R K~~]]	+	[[Category: Louder RK]]
-	[[Category: Nogales, E]]	+	[[Category: Nogales E]]
-	~~[[Category: Core promoter]]~~	+
-	~~[[Category: Dna binding]]~~	+
-	~~[[Category: General transcription factor]]~~	+
-	~~[[Category: Preinitiation complex]]~~	+
-	~~[[Category: Rna polymerase ii]]~~	+
-	~~[[Category: Tfiia]]~~	+
-	~~[[Category: Tfiid]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 19:56, 10 April 2020

OCA — Fri, 10 Apr 2020 19:56:49 GMT

←Older revision		Revision as of 19:56, 10 April 2020
Line 3:		Line 3:
	<SX load='5fur' size='340' side='right' viewer='molstar' caption='[[5fur]], [[Resolution\|resolution]] 8.50Å' scene=''>		<SX load='5fur' size='340' side='right' viewer='molstar' caption='[[5fur]], [[Resolution\|resolution]] 8.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fur]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FUR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fur]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FUR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fur OCA], [http://pdbe.org/5fur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fur RCSB], [http://www.ebi.ac.uk/pdbsum/5fur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fur ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fur OCA], [http://pdbe.org/5fur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fur RCSB], [http://www.ebi.ac.uk/pdbsum/5fur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fur ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 18:19, 6 March 2020

OCA — Fri, 06 Mar 2020 18:19:45 GMT

←Older revision		Revision as of 18:19, 6 March 2020
Line 1:		Line 1:

	==Structure of human TFIID-IIA bound to core promoter DNA==		==Structure of human TFIID-IIA bound to core promoter DNA==
-	<~~StructureSection~~ load='5fur' size='340' side='right' caption='[[5fur]], [[Resolution\|resolution]] 8.50Å' scene=''>	+	<SX load='5fur' size='340' side='right' viewer='molstar' caption='[[5fur]], [[Resolution\|resolution]] 8.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5fur]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FUR FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fur]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FUR FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5fur" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fur" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[TATA-binding protein 3D structures\|TATA-binding protein 3D structures]]
		+	*[[Transcription initiation factors 3D structures\|Transcription initiation factors 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Chacon, P]]		[[Category: Chacon, P]]
	[[Category: Fang, J]]		[[Category: Fang, J]]

OCA at 03:16, 16 November 2017

OCA — Thu, 16 Nov 2017 03:16:54 GMT

←Older revision		Revision as of 03:16, 16 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5fur" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fur" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[TATA-Binding Protein\|TATA-Binding Protein]]
-	*[[Transcription initiation factor\|Transcription initiation factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:54, 4 August 2017

OCA — Fri, 04 Aug 2017 03:54:44 GMT

←Older revision		Revision as of 03:54, 4 August 2017
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[5fur]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FUR FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fur]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FUR FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fur OCA], [http://pdbe.org/5fur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fur RCSB], [http://www.ebi.ac.uk/pdbsum/5fur PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fur OCA], [http://pdbe.org/5fur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fur RCSB], [http://www.ebi.ac.uk/pdbsum/5fur PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fur ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5fur" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fur" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[TATA-Binding Protein\|TATA-Binding Protein]]
		+	*[[Transcription initiation factor\|Transcription initiation factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:43, 10 May 2016

OCA — Tue, 10 May 2016 17:43:36 GMT

←Older revision		Revision as of 17:43, 10 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~5fur~~ is ~~ON HOLD~~	+	==Structure of human TFIID-IIA bound to core promoter DNA==
		+	<StructureSection load='5fur' size='340' side='right' caption='[[5fur]], [[Resolution\|resolution]] 8.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fur]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FUR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FUR FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fur OCA], [http://pdbe.org/5fur PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fur RCSB], [http://www.ebi.ac.uk/pdbsum/5fur PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN]] Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:[http://omim.org/entry/314250 314250]]; also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.<ref>PMID:12928496</ref> <ref>PMID:17273961</ref> [[http://www.uniprot.org/uniprot/TAF2_HUMAN TAF2_HUMAN]] Microcephaly-thin corpus callosum-intellectual disability syndrome. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/TBP_HUMAN TBP_HUMAN]] Defects in TBP are the cause of spinocerebellar ataxia type 17 (SCA17) [MIM:[http://omim.org/entry/607136 607136]]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA17 is an autosomal dominant cerebellar ataxia (ADCA) characterized by widespread cerebral and cerebellar atrophy, dementia and extrapyramidal signs. The molecular defect in SCA17 is the expansion of a CAG repeat in the coding region of TBP. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.<ref>PMID:11313753</ref> <ref>PMID:11448935</ref> <ref>PMID:11939898</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TAF8_HUMAN TAF8_HUMAN]] Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity). [[http://www.uniprot.org/uniprot/TF2AA_HUMAN TF2AA_HUMAN]] TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.<ref>PMID:11030333</ref> <ref>PMID:16537915</ref> [[http://www.uniprot.org/uniprot/TAF1_HUMAN TAF1_HUMAN]] Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.<ref>PMID:2038334</ref> <ref>PMID:8450888</ref> <ref>PMID:8625415</ref> <ref>PMID:9660973</ref> <ref>PMID:9858607</ref> <ref>PMID:11278496</ref> <ref>PMID:15053879</ref> [[http://www.uniprot.org/uniprot/TAF2_HUMAN TAF2_HUMAN]] Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.<ref>PMID:9418870</ref> <ref>PMID:9774672</ref> [[http://www.uniprot.org/uniprot/TAF7_HUMAN TAF7_HUMAN]] Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). [[http://www.uniprot.org/uniprot/TBP_HUMAN TBP_HUMAN]] General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.<ref>PMID:15970593</ref> [[http://www.uniprot.org/uniprot/T2AG_HUMAN T2AG_HUMAN]] TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.<ref>PMID:11030333</ref> [[http://www.uniprot.org/uniprot/TAF6_HUMAN TAF6_HUMAN]] TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter. TFIID comprises the TATA-binding protein (TBP) and 13 TBP-associated factors (TAF1-13), which specifically interact with a variety of core promoter DNA sequences. Here we present the structure of human TFIID in complex with TFIIA and core promoter DNA, determined by single-particle cryo-electron microscopy at sub-nanometre resolution. All core promoter elements are contacted by subunits of TFIID, with TAF1 and TAF2 mediating major interactions with the downstream promoter. TFIIA bridges the TBP-TATA complex with lobe B of TFIID. We also present the cryo-electron microscopy reconstruction of a fully assembled human TAF-less PIC. Superposition of common elements between the two structures provides novel insights into the general role of TFIID in promoter recognition, PIC assembly, and transcription initiation.

-	~~Authors:~~ Louder~~, R.K.~~, He, Y., Lopez-Blanco~~, J.R.~~, Fang, J., Chacon, P., Nogales, E.	+	Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.,Louder RK, He Y, Lopez-Blanco JR, Fang J, Chacon P, Nogales E Nature. 2016 Mar 31;531(7596):604-9. doi: 10.1038/nature17394. Epub 2016 Mar 23. PMID:27007846<ref>PMID:27007846</ref>

-	~~Description: Structure~~ of ~~human TFIID-IIA bound to core promoter DNA~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Nogales, E]]~~	+	<div class="pdbe-citations 5fur" style="background-color:#fffaf0;"></div>
-	~~[[Category: He, Y]]~~	+	== References ==
-	~~[[Category: Lopez-Blanco, J.R]]~~	+	<references/>
-	~~[[Category: Louder, R.K]]~~	+	__TOC__
-	[[Category: ~~Fang, J~~]]	+	</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Chacon, P]]		[[Category: Chacon, P]]
		+	[[Category: Fang, J]]
		+	[[Category: He, Y]]
		+	[[Category: Lopez-Blanco, J R]]
		+	[[Category: Louder, R K]]
		+	[[Category: Nogales, E]]
		+	[[Category: Core promoter]]
		+	[[Category: Dna binding]]
		+	[[Category: General transcription factor]]
		+	[[Category: Preinitiation complex]]
		+	[[Category: Rna polymerase ii]]
		+	[[Category: Tfiia]]
		+	[[Category: Tfiid]]
		+	[[Category: Transcription]]

OCA at 12:13, 2 March 2016

OCA — Wed, 02 Mar 2016 12:13:04 GMT

←Older revision		Revision as of 12:13, 2 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fur is ON HOLD ~~until sometime in the future~~	+	The entry 5fur is ON HOLD

	Authors: Louder, R.K., He, Y., Lopez-Blanco, J.R., Fang, J., Chacon, P., Nogales, E.		Authors: Louder, R.K., He, Y., Lopez-Blanco, J.R., Fang, J., Chacon, P., Nogales, E.

OCA: Protected "5fur" [edit=sysop:move=sysop]

OCA — Wed, 03 Feb 2016 13:28:47 GMT

Protected "5fur" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:28, 3 February 2016

OCA: New page: '''Unreleased structure''' The entry 5fur is ON HOLD until sometime in the future Authors: Louder, R.K., He, Y., Lopez-Blanco, J.R., Fang, J., Chacon, P., Nogales, E. Description: Stru...

OCA — Wed, 03 Feb 2016 13:28:46 GMT

New page: '''Unreleased structure''' The entry 5fur is ON HOLD until sometime in the future Authors: Louder, R.K., He, Y., Lopez-Blanco, J.R., Fang, J., Chacon, P., Nogales, E. Description: Stru...

New page

'''Unreleased structure'''

The entry 5fur is ON HOLD until sometime in the future

Authors: Louder, R.K., He, Y., Lopez-Blanco, J.R., Fang, J., Chacon, P., Nogales, E.

Description: Structure of human TFIID-IIA bound to core promoter DNA
[[Category: Unreleased Structures]]
[[Category: Nogales, E]]
[[Category: He, Y]]
[[Category: Lopez-Blanco, J.R]]
[[Category: Louder, R.K]]
[[Category: Fang, J]]
[[Category: Chacon, P]]