5fve - Revision history

OCA at 13:28, 26 July 2023

OCA — Wed, 26 Jul 2023 13:28:33 GMT

←Older revision		Revision as of 13:28, 26 July 2023
Line 3:		Line 3:
	<StructureSection load='5fve' size='340' side='right'caption='[[5fve]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='5fve' size='340' side='right'caption='[[5fve]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fve]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Campylobacter_pylori Campylobacter~~ pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FVE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fve]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FVE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=2HO:3~~,~~4-DIFLUOROBENZAMIDE'>2HO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.07Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>[https~~:~~//en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase]~~, ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HO:3,4-DIFLUOROBENZAMIDE'>2HO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fve OCA], [https://pdbe.org/5fve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fve RCSB], [https://www.ebi.ac.uk/pdbsum/5fve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fve ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fve OCA], [https://pdbe.org/5fve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fve RCSB], [https://www.ebi.ac.uk/pdbsum/5fve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fve ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DPO3B_HELPY DPO3B_HELPY]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).	+	[https://www.uniprot.org/uniprot/DPO3B_HELPY DPO3B_HELPY] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5fve" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fve" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Campylobacter~~ pylori]]	+	[[Category: Helicobacter pylori 26695]]
-	~~[[Category: DNA-directed DNA polymerase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gourinath, S]]	+	[[Category: Gourinath S]]
-	[[Category: Pandey, P]]	+	[[Category: Pandey P]]
-	~~[[Category: Dna clamp]]~~	+
-	~~[[Category: Sliding clamp]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 14:51, 3 March 2021

OCA — Wed, 03 Mar 2021 14:51:49 GMT

←Older revision		Revision as of 14:51, 3 March 2021
Line 3:		Line 3:
	<StructureSection load='5fve' size='340' side='right'caption='[[5fve]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='5fve' size='340' side='right'caption='[[5fve]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fve]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FVE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fve]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FVE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HO:3,4-DIFLUOROBENZAMIDE'>2HO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HO:3,4-DIFLUOROBENZAMIDE'>2HO</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fve OCA], [~~http~~://pdbe.org/5fve PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fve RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fve PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fve ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fve OCA], [https://pdbe.org/5fve PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fve RCSB], [https://www.ebi.ac.uk/pdbsum/5fve PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fve ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DPO3B_HELPY DPO3B_HELPY]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).	+	[[https://www.uniprot.org/uniprot/DPO3B_HELPY DPO3B_HELPY]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5fve" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fve" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:39, 6 May 2020

OCA — Wed, 06 May 2020 07:39:15 GMT

←Older revision		Revision as of 07:39, 6 May 2020
Line 1:		Line 1:

	==Crystal Structure of Helicobacter pylori beta clamp in complex with 3, 4-Difluorobenzamide==		==Crystal Structure of Helicobacter pylori beta clamp in complex with 3, 4-Difluorobenzamide==
-	<StructureSection load='5fve' size='340' side='right' caption='[[5fve]], [[Resolution\|resolution]] 2.07Å' scene=''>	+	<StructureSection load='5fve' size='340' side='right'caption='[[5fve]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fve]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FVE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fve]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FVE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HO:3,4-DIFLUOROBENZAMIDE'>2HO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HO:3,4-DIFLUOROBENZAMIDE'>2HO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fve OCA], [http://pdbe.org/5fve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fve RCSB], [http://www.ebi.ac.uk/pdbsum/5fve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fve ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fve OCA], [http://pdbe.org/5fve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fve RCSB], [http://www.ebi.ac.uk/pdbsum/5fve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fve ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[DNA polymerase\|DNA polymerase]]	+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	[[Category: Campylobacter pylori]]		[[Category: Campylobacter pylori]]
	[[Category: DNA-directed DNA polymerase]]		[[Category: DNA-directed DNA polymerase]]
		+	[[Category: Large Structures]]
	[[Category: Gourinath, S]]		[[Category: Gourinath, S]]
	[[Category: Pandey, P]]		[[Category: Pandey, P]]

OCA at 08:45, 18 July 2018

OCA — Wed, 18 Jul 2018 08:45:01 GMT

←Older revision		Revision as of 08:45, 18 July 2018
Line 3:		Line 3:
	<StructureSection load='5fve' size='340' side='right' caption='[[5fve]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='5fve' size='340' side='right' caption='[[5fve]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fve]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FVE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fve]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FVE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HO:3,4-DIFLUOROBENZAMIDE'>2HO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HO:3,4-DIFLUOROBENZAMIDE'>2HO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DPO3B_HELPY DPO3B_HELPY]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).		[[http://www.uniprot.org/uniprot/DPO3B_HELPY DPO3B_HELPY]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The characteristic of interaction with various enzymes and processivity-promoting nature during DNA replication makes beta-clamp an important drug target. Helicobacter pylori (H. pylori) have several unique features in DNA replication machinery that makes it different from other microorganisms. To find out whether difference in DNA replication proteins behavior accounts for any difference in drug response when compared to E. coli, in the present study, we have tested E. coli beta-clamp inhibitor molecules against H. pylori beta-clamp. Various approaches were used to test the binding of inhibitors to H. pylori beta-clamp including docking, surface competition assay, complex structure determination, as well as antimicrobial assay. Out of five shortlisted inhibitor molecules on the basis of docking score, three molecules, 5-chloroisatin, carprofen, and 3,4-difluorobenzamide were co-crystallized with H. pylori beta-clamp and the structures show that they bind at the protein-protein interaction site as expected. In vivo studies showed only two molecules, 5-chloroisatin, and 3,4-difluorobenzamide inhibited the growth of the pylori with MIC values in micro molar range, which is better than the inhibitory effect of the same drugs on E. coli. Therefore, the evaluation of such drugs against H. pylori may explore the possibility to use to generate species-specific pharmacophore for development of new drugs against H. pylori.
		+
		+	Screening of E. coli beta-clamp Inhibitors Revealed that Few Inhibit Helicobacter pylori More Effectively: Structural and Functional Characterization.,Pandey P, Verma V, Dhar SK, Gourinath S Antibiotics (Basel). 2018 Jan 11;7(1). pii: antibiotics7010005. doi:, 10.3390/antibiotics7010005. PMID:29324718<ref>PMID:29324718</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5fve" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase\|DNA polymerase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Campylobacter pylori]]
	[[Category: DNA-directed DNA polymerase]]		[[Category: DNA-directed DNA polymerase]]
	[[Category: Gourinath, S]]		[[Category: Gourinath, S]]

OCA at 01:30, 11 March 2017

OCA — Sat, 11 Mar 2017 01:30:58 GMT

←Older revision		Revision as of 01:30, 11 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fve is ~~ON HOLD until Feb 05 2018~~	+	==Crystal Structure of Helicobacter pylori beta clamp in complex with 3, 4-Difluorobenzamide==
-		+	<StructureSection load='5fve' size='340' side='right' caption='[[5fve]], [[Resolution\|resolution]] 2.07Å' scene=''>
-	~~Authors~~: ~~Pandey~~, P., ~~Gourinath~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5fve]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FVE FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure~~ of ~~Helicobacter pylori beta clamp~~ in ~~complex with~~ 3, 4-~~Difluorobenzamide~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HO:3,4-DIFLUOROBENZAMIDE'>2HO</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fve OCA], [http://pdbe.org/5fve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fve RCSB], [http://www.ebi.ac.uk/pdbsum/5fve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fve ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DPO3B_HELPY DPO3B_HELPY]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: DNA-directed DNA polymerase]]
		+	[[Category: Gourinath, S]]
	[[Category: Pandey, P]]		[[Category: Pandey, P]]
-	[[Category: ~~Gourinath, S~~]]	+	[[Category: Dna clamp]]
		+	[[Category: Sliding clamp]]
		+	[[Category: Transferase]]

OCA at 12:14, 2 March 2016

OCA — Wed, 02 Mar 2016 12:14:26 GMT

←Older revision		Revision as of 12:14, 2 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fve is ON HOLD	+	The entry 5fve is ON HOLD until Feb 05 2018

	Authors: Pandey, P., Gourinath, S.		Authors: Pandey, P., Gourinath, S.

OCA: Protected "5fve" [edit=sysop:move=sysop]

OCA — Sun, 21 Feb 2016 00:26:42 GMT

Protected "5fve" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:26, 21 February 2016

OCA: New page: '''Unreleased structure''' The entry 5fve is ON HOLD Authors: Pandey, P., Gourinath, S. Description: Crystal Structure of Helicobacter pylori beta clamp in complex with 3, 4-Difluorobe...

OCA — Sun, 21 Feb 2016 00:26:40 GMT

New page: '''Unreleased structure''' The entry 5fve is ON HOLD Authors: Pandey, P., Gourinath, S. Description: Crystal Structure of Helicobacter pylori beta clamp in complex with 3, 4-Difluorobe...

New page

'''Unreleased structure'''

The entry 5fve is ON HOLD

Authors: Pandey, P., Gourinath, S.

Description: Crystal Structure of Helicobacter pylori beta clamp in complex with 3, 4-Difluorobenzamide
[[Category: Unreleased Structures]]
[[Category: Pandey, P]]
[[Category: Gourinath, S]]