5fwy - Revision history

OCA at 13:30, 26 July 2023

OCA — Wed, 26 Jul 2023 13:30:03 GMT

←Older revision		Revision as of 13:30, 26 July 2023
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	<StructureSection load='5fwy' size='340' side='right'caption='[[5fwy]], [[Resolution\|resolution]] 2.12Å' scene=''>		<StructureSection load='5fwy' size='340' side='right'caption='[[5fwy]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fwy]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FWY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fwy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FWY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.12Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fwy OCA], [~~http~~://pdbe.org/5fwy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fwy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fwy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fwy ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fwy OCA], [https://pdbe.org/5fwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fwy RCSB], [https://www.ebi.ac.uk/pdbsum/5fwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fwy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> [[http://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).	+	[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Garcia-Nafria, J~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Greger, I H~~]]	+	[[Category: Garcia-Nafria J]]
-	[[Category: ~~Herguedas, B~~]]	+	[[Category: Greger IH]]
-	[[Category: ~~Transport protein~~]]	+	[[Category: Herguedas B]]

OCA at 07:41, 6 May 2020

OCA — Wed, 06 May 2020 07:41:13 GMT

←Older revision		Revision as of 07:41, 6 May 2020
Line 1:		Line 1:

	==Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer==		==Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer==
-	<StructureSection load='5fwy' size='340' side='right' caption='[[5fwy]], [[Resolution\|resolution]] 2.12Å' scene=''>	+	<StructureSection load='5fwy' size='340' side='right'caption='[[5fwy]], [[Resolution\|resolution]] 2.12Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fwy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FWY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FWY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fwy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FWY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FWY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fwy OCA], [http://pdbe.org/5fwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fwy RCSB], [http://www.ebi.ac.uk/pdbsum/5fwy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fwy OCA], [http://pdbe.org/5fwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fwy RCSB], [http://www.ebi.ac.uk/pdbsum/5fwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fwy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5fwy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fwy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Garcia-Nafria, J]]		[[Category: Garcia-Nafria, J]]
	[[Category: Greger, I H]]		[[Category: Greger, I H]]
	[[Category: Herguedas, B]]		[[Category: Herguedas, B]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 19:00, 10 May 2016

OCA — Tue, 10 May 2016 19:00:25 GMT

←Older revision		Revision as of 19:00, 10 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fwy is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer==
		+	<StructureSection load='5fwy' size='340' side='right' caption='[[5fwy]], [[Resolution\|resolution]] 2.12Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fwy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FWY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fwy OCA], [http://pdbe.org/5fwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fwy RCSB], [http://www.ebi.ac.uk/pdbsum/5fwy PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> [[http://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AMPA-type glutamate receptors (AMPARs), which are central mediators of rapid neurotransmission and synaptic plasticity, predominantly exist as heteromers of the subunits GluA1 to GluA4. Here we report the first AMPAR heteromer structures, which deviate substantially from existing GluA2 homomer structures. Crystal structures of the GluA2/3 and GluA2/4 N-terminal domains reveal a novel compact conformation with an alternating arrangement of the four subunits around a central axis. This organization is confirmed by cysteine cross-linking in full-length receptors, and it permitted us to determine the structure of an intact GluA2/3 receptor by cryogenic electron microscopy. Two models in the ligand-free state, at resolutions of 8.25 and 10.3 angstroms, exhibit substantial vertical compression and close associations between domain layers, reminiscent of N-methyl-D-aspartate receptors. Model 1 resembles a resting state and model 2 a desensitized state, thus providing snapshots of gating transitions in the nominal absence of ligand. Our data reveal organizational features of heteromeric AMPARs and provide a framework to decipher AMPAR architecture and signaling.

-	~~Authors: Herguedas~~, B., Garcia-Nafria, J., ~~Greger~~, I.H.	+	Structure and organization of heteromeric AMPA-type glutamate receptors.,Herguedas B, Garcia-Nafria J, Cais O, Fernandez-Leiro R, Krieger J, Ho H, Greger IH Science. 2016 Apr 29;352(6285):aad3873. doi: 10.1126/science.aad3873. Epub 2016, Mar 10. PMID:26966189<ref>PMID:26966189</ref>

-	~~Description: Structure of~~ a ~~protein~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Greger, I.H]]~~	+	<div class="pdbe-citations 5fwy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Garcia-Nafria, J]]		[[Category: Garcia-Nafria, J]]
		+	[[Category: Greger, I H]]
	[[Category: Herguedas, B]]		[[Category: Herguedas, B]]
		+	[[Category: Transport protein]]

OCA at 00:52, 10 March 2016

OCA — Thu, 10 Mar 2016 00:52:26 GMT

←Older revision		Revision as of 00:52, 10 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fwy is ON HOLD	+	The entry 5fwy is ON HOLD until Paper Publication

	Authors: Herguedas, B., Garcia-Nafria, J., Greger, I.H.		Authors: Herguedas, B., Garcia-Nafria, J., Greger, I.H.

OCA: Protected "5fwy" [edit=sysop:move=sysop]

OCA — Wed, 02 Mar 2016 12:18:23 GMT

Protected "5fwy" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:18, 2 March 2016

OCA: New page: '''Unreleased structure''' The entry 5fwy is ON HOLD Authors: Herguedas, B., Garcia-Nafria, J., Greger, I.H. Description: Structure of a protein Category: Unreleased Structures [[C...

OCA — Wed, 02 Mar 2016 12:18:22 GMT

New page: '''Unreleased structure''' The entry 5fwy is ON HOLD Authors: Herguedas, B., Garcia-Nafria, J., Greger, I.H. Description: Structure of a protein Category: Unreleased Structures [[C...

New page

'''Unreleased structure'''

The entry 5fwy is ON HOLD

Authors: Herguedas, B., Garcia-Nafria, J., Greger, I.H.

Description: Structure of a protein
[[Category: Unreleased Structures]]
[[Category: Greger, I.H]]
[[Category: Garcia-Nafria, J]]
[[Category: Herguedas, B]]