5fy9 - Revision history

OCA at 13:31, 26 July 2023

OCA — Wed, 26 Jul 2023 13:31:33 GMT

←Older revision		Revision as of 13:31, 26 July 2023
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	<StructureSection load='5fy9' size='340' side='right'caption='[[5fy9]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='5fy9' size='340' side='right'caption='[[5fy9]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fy9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FY9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FY9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.03Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fxv\|5fxv]], [[5fxw\|5fxw]], [[5fxx\|5fxx]], [[5fxz\|5fxz]], [[5fy0\|5fy0]], [[5fy1\|5fy1]], [[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fy9 OCA], [~~http~~://pdbe.org/5fy9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fy9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fy9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fy9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fy9 OCA], [https://pdbe.org/5fy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fy9 RCSB], [https://www.ebi.ac.uk/pdbsum/5fy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fy9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>	+	[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>

	==See Also==		==See Also==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Burgess-Brown~~, N A]]~~	+	[[Category: Burgess-Brown NA]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Gileadi C]]
-	[[Category: Gileadi, C]]	+	[[Category: Johansson C]]
-	[[Category: Johansson, C]]	+	[[Category: Kupinska K]]
-	[[Category: Kupinska, K]]	+	[[Category: Nowak R]]
-	[[Category: Nowak, R]]	+	[[Category: Oppermann U]]
-	[[Category: Oppermann, U]]	+	[[Category: Srikannathasan V]]
-	[[Category: Srikannathasan, V]]	+	[[Category: Strain-Damerell C]]
-	[[Category: Strain-Damerell, C]]	+	[[Category: Szykowska A]]
-	[[Category: Szykowska, A]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Jarid1b]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Plu1]]~~	+
-	~~[[Category: Tca intermediate~~]]	+

OCA at 07:43, 6 May 2020

OCA — Wed, 06 May 2020 07:43:02 GMT

←Older revision		Revision as of 07:43, 6 May 2020
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	==Crystal structure of the catalytic domain of human JARID1B in complex with pyruvate==		==Crystal structure of the catalytic domain of human JARID1B in complex with pyruvate==
-	<StructureSection load='5fy9' size='340' side='right' caption='[[5fy9]], [[Resolution\|resolution]] 2.03Å' scene=''>	+	<StructureSection load='5fy9' size='340' side='right'caption='[[5fy9]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fy9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FY9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fy9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FY9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FY9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fxv\|5fxv]], [[5fxw\|5fxw]], [[5fxx\|5fxx]], [[5fxz\|5fxz]], [[5fy0\|5fy0]], [[5fy1\|5fy1]], [[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fxv\|5fxv]], [[5fxw\|5fxw]], [[5fxx\|5fxx]], [[5fxz\|5fxz]], [[5fy0\|5fy0]], [[5fy1\|5fy1]], [[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fy9 OCA], [http://pdbe.org/5fy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fy9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fy9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fy9 OCA], [http://pdbe.org/5fy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fy9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fy9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>		[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
		+
		+	==See Also==
		+	*[[Jumonji domain-containing protein 3D structures\|Jumonji domain-containing protein 3D structures]]
		+	*[[Lysine-specific histone demethylase 3D structures\|Lysine-specific histone demethylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 20:31, 24 January 2018

OCA — Wed, 24 Jan 2018 20:31:59 GMT

←Older revision		Revision as of 20:31, 24 January 2018
Line 3:		Line 3:
	<StructureSection load='5fy9' size='340' side='right' caption='[[5fy9]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='5fy9' size='340' side='right' caption='[[5fy9]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fy9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FY9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fxv\|5fxv]], [[5fxw\|5fxw]], [[5fxx\|5fxx]], [[5fxz\|5fxz]], [[5fy0\|5fy0]], [[5fy1\|5fy1]], [[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fxv\|5fxv]], [[5fxw\|5fxw]], [[5fxx\|5fxx]], [[5fxz\|5fxz]], [[5fy0\|5fy0]], [[5fy1\|5fy1]], [[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]]</td></tr>
Line 14:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
	[[Category: Burgess-Brown, N A]]		[[Category: Burgess-Brown, N A]]
-	[[Category: Delft, F ~~Von~~]]	+	[[Category: Delft, F von]]
	[[Category: Edwards, A M]]		[[Category: Edwards, A M]]
	[[Category: Gileadi, C]]		[[Category: Gileadi, C]]

OCA at 16:19, 22 March 2017

OCA — Wed, 22 Mar 2017 16:19:29 GMT

←Older revision		Revision as of 16:19, 22 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fy9 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the catalytic domain of human JARID1B in complex with pyruvate==
-		+	<StructureSection load='5fy9' size='340' side='right' caption='[[5fy9]], [[Resolution\|resolution]] 2.03Å' scene=''>
-	~~Authors~~: ~~Nowak~~, R., ~~Srikannathasan~~, V., ~~Johansson~~, C., ~~Gileadi~~, C., ~~Kupinska~~, K., ~~Strain~~-~~Damerell~~, C., ~~Szykowska~~, A., ~~Von Delft, F~~., ~~Burgess~~-~~Brown~~, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., ~~Oppermann, U.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5fy9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FY9 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the catalytic domain of human JARID1B in complex with pyruvate~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fxv\|5fxv]], [[5fxw\|5fxw]], [[5fxx\|5fxx]], [[5fxz\|5fxz]], [[5fy0\|5fy0]], [[5fy1\|5fy1]], [[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fy9 OCA], [http://pdbe.org/5fy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fy9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fy9 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Burgess-Brown, N A]]
		+	[[Category: Delft, F Von]]
		+	[[Category: Edwards, A M]]
		+	[[Category: Gileadi, C]]
		+	[[Category: Johansson, C]]
		+	[[Category: Kupinska, K]]
	[[Category: Nowak, R]]		[[Category: Nowak, R]]
-	[[Category: Arrowsmith, C.H]]
-	[[Category: Gileadi, C]]
	[[Category: Oppermann, U]]		[[Category: Oppermann, U]]
		+	[[Category: Srikannathasan, V]]
		+	[[Category: Strain-Damerell, C]]
	[[Category: Szykowska, A]]		[[Category: Szykowska, A]]
-	[[Category: ~~Burgess-Brown, N.A~~]]	+	[[Category: Jarid1b]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Oxidoreductase]]
-	[[Category: ~~Edwards, A.M~~]]	+	[[Category: Plu1]]
-	[[Category: ~~Johansson, C]]~~	+	[[Category: Tca intermediate]]
-	~~[[Category: Strain-Damerell, C]]~~	+
-	~~[[Category: Srikannathasan, V]]~~	+
-	~~[[Category: Bountra, C]]~~	+
-	~~[[Category: Kupinska, K~~]]	+

OCA at 08:45, 9 March 2017

OCA — Thu, 09 Mar 2017 08:45:18 GMT

←Older revision		Revision as of 08:45, 9 March 2017
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Nowak, R]]		[[Category: Nowak, R]]
-	[[Category: Burgess-Brown, N.A]]
-	[[Category: Bountra, C]]
-	[[Category: Kupinska, K]]
	[[Category: Arrowsmith, C.H]]		[[Category: Arrowsmith, C.H]]
	[[Category: Gileadi, C]]		[[Category: Gileadi, C]]
	[[Category: Oppermann, U]]		[[Category: Oppermann, U]]
	[[Category: Szykowska, A]]		[[Category: Szykowska, A]]
		+	[[Category: Burgess-Brown, N.A]]
	[[Category: Von Delft, F]]		[[Category: Von Delft, F]]
	[[Category: Edwards, A.M]]		[[Category: Edwards, A.M]]
Line 20:		Line 18:
	[[Category: Strain-Damerell, C]]		[[Category: Strain-Damerell, C]]
	[[Category: Srikannathasan, V]]		[[Category: Srikannathasan, V]]
		+	[[Category: Bountra, C]]
		+	[[Category: Kupinska, K]]

OCA: Protected "5fy9" [edit=sysop:move=sysop]

OCA — Tue, 10 May 2016 23:14:14 GMT

Protected "5fy9" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:14, 10 May 2016

OCA: New page: '''Unreleased structure''' The entry 5fy9 is ON HOLD until Paper Publication Authors: Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szyko...

OCA — Tue, 10 May 2016 23:14:13 GMT

New page: '''Unreleased structure''' The entry 5fy9 is ON HOLD until Paper Publication Authors: Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szyko...

New page

'''Unreleased structure'''

The entry 5fy9 is ON HOLD until Paper Publication

Authors: Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.

Description: Crystal structure of the catalytic domain of human JARID1B in complex with pyruvate
[[Category: Unreleased Structures]]
[[Category: Nowak, R]]
[[Category: Burgess-Brown, N.A]]
[[Category: Bountra, C]]
[[Category: Kupinska, K]]
[[Category: Arrowsmith, C.H]]
[[Category: Gileadi, C]]
[[Category: Oppermann, U]]
[[Category: Szykowska, A]]
[[Category: Von Delft, F]]
[[Category: Edwards, A.M]]
[[Category: Johansson, C]]
[[Category: Strain-Damerell, C]]
[[Category: Srikannathasan, V]]