5fz6 - Revision history

OCA at 13:32, 26 July 2023

OCA — Wed, 26 Jul 2023 13:32:54 GMT

←Older revision		Revision as of 13:32, 26 July 2023
Line 3:		Line 3:
	<StructureSection load='5fz6' size='340' side='right'caption='[[5fz6]], [[Resolution\|resolution]] 2.33Å' scene=''>		<StructureSection load='5fz6' size='340' side='right'caption='[[5fz6]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fz6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZ6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FZ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MN1:4-CARBOXYPIPERIDINE'>MN1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.33Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fy9\|5fy9]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzg\|5fzg]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MN1:4-CARBOXYPIPERIDINE'>MN1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fz6 OCA], [~~http~~://pdbe.org/5fz6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fz6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fz6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fz6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fz6 OCA], [https://pdbe.org/5fz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fz6 RCSB], [https://www.ebi.ac.uk/pdbsum/5fz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>	+	[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>

	==See Also==		==See Also==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Brennan~~, P E~~]]	+	[[Category: Brennan PE]]
-	[[Category: Burgess-Brown~~, N A~~]]	+	[[Category: Burgess-Brown NA]]
-	[[Category: Collins, P]]	+	[[Category: Collins P]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Gileadi C]]
-	[[Category: Gileadi, C]]	+	[[Category: Johansson C]]
-	[[Category: Johansson, C]]	+	[[Category: Krojer T]]
-	[[Category: Krojer, T]]	+	[[Category: Kupinska K]]
-	[[Category: Kupinska, K]]	+	[[Category: Nowak R]]
-	[[Category: Nowak, R]]	+	[[Category: Oppermann U]]
-	[[Category: Oppermann, U]]	+	[[Category: Pearce N]]
-	[[Category: Pearce, N]]	+	[[Category: Strain-Damerell C]]
-	[[Category: Strain-Damerell, C]]	+	[[Category: Szykowska A]]
-	[[Category: Szykowska, A]]	+	[[Category: Talon R]]
-	[[Category: Talon, R]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Diamond i04-1]]~~	+
-	~~[[Category: Fragment screening]]~~	+
-	~~[[Category: Jarid1b]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Pandda]]~~	+
-	~~[[Category: Plu1]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Structural genomic~~]]	+

OCA at 06:31, 13 May 2020

OCA — Wed, 13 May 2020 06:31:11 GMT

←Older revision		Revision as of 06:31, 13 May 2020
Line 1:		Line 1:

	==Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment N05859b (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)==		==Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment N05859b (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)==
-	<StructureSection load='5fz6' size='340' side='right' caption='[[5fz6]], [[Resolution\|resolution]] 2.33Å' scene=''>	+	<StructureSection load='5fz6' size='340' side='right'caption='[[5fz6]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FZ6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MN1:4-CARBOXYPIPERIDINE'>MN1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MN1:4-CARBOXYPIPERIDINE'>MN1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fy9\|5fy9]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzg\|5fzg]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fy9\|5fy9]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzg\|5fzg]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fz6 OCA], [http://pdbe.org/5fz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fz6 RCSB], [http://www.ebi.ac.uk/pdbsum/5fz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fz6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fz6 OCA], [http://pdbe.org/5fz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fz6 RCSB], [http://www.ebi.ac.uk/pdbsum/5fz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>		[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
		+
		+	==See Also==
		+	*[[Jumonji domain-containing protein 3D structures\|Jumonji domain-containing protein 3D structures]]
		+	*[[Lysine-specific histone demethylase 3D structures\|Lysine-specific histone demethylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 20:33, 24 January 2018

OCA — Wed, 24 Jan 2018 20:33:08 GMT

←Older revision		Revision as of 20:33, 24 January 2018
Line 3:		Line 3:
	<StructureSection load='5fz6' size='340' side='right' caption='[[5fz6]], [[Resolution\|resolution]] 2.33Å' scene=''>		<StructureSection load='5fz6' size='340' side='right' caption='[[5fz6]], [[Resolution\|resolution]] 2.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fz6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZ6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZ6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MN1:4-CARBOXYPIPERIDINE'>MN1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MN1:4-CARBOXYPIPERIDINE'>MN1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fy9\|5fy9]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzg\|5fzg]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fy4\|5fy4]], [[5fy5\|5fy5]], [[5fy7\|5fy7]], [[5fy8\|5fy8]], [[5fy9\|5fy9]], [[5fyb\|5fyb]], [[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzg\|5fzg]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fz6 OCA], [http://pdbe.org/5fz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fz6 RCSB], [http://www.ebi.ac.uk/pdbsum/5fz6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fz6 OCA], [http://pdbe.org/5fz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fz6 RCSB], [http://www.ebi.ac.uk/pdbsum/5fz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fz6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
Line 19:		Line 20:
	[[Category: Burgess-Brown, N A]]		[[Category: Burgess-Brown, N A]]
	[[Category: Collins, P]]		[[Category: Collins, P]]
-	[[Category: Delft, F ~~Von~~]]	+	[[Category: Delft, F von]]
	[[Category: Edwards, A M]]		[[Category: Edwards, A M]]
	[[Category: Gileadi, C]]		[[Category: Gileadi, C]]

OCA: Protected "5fz6" [edit=sysop:move=sysop]

OCA — Wed, 11 May 2016 13:05:53 GMT

Protected "5fz6" [edit=sysop:move=sysop]

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Revision as of 13:05, 11 May 2016

OCA: New page: ==Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment N05859b (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)...

OCA — Wed, 11 May 2016 13:05:50 GMT

New page: ==Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment N05859b (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)...

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==Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment N05859b (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)==
<StructureSection load='5fz6' size='340' side='right' caption='[[5fz6]], [[Resolution|resolution]] 2.33Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5fz6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZ6 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZ6 FirstGlance]. 
</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MN1:4-CARBOXYPIPERIDINE'>MN1</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5fy4|5fy4]], [[5fy5|5fy5]], [[5fy7|5fy7]], [[5fy8|5fy8]], [[5fy9|5fy9]], [[5fyb|5fyb]], [[5fyc|5fyc]], [[5fyh|5fyh]], [[5fyi|5fyi]], [[5fym|5fym]], [[5fys|5fys]], [[5fyt|5fyt]], [[5fyu|5fyu]], [[5fyv|5fyv]], [[5fyy|5fyy]], [[5fyz|5fyz]], [[5fz0|5fz0]], [[5fz1|5fz1]], [[5fz3|5fz3]], [[5fz4|5fz4]], [[5fz7|5fz7]], [[5fz8|5fz8]], [[5fz9|5fz9]], [[5fza|5fza]], [[5fzb|5fzb]], [[5fzc|5fzc]], [[5fzd|5fzd]], [[5fze|5fze]], [[5fzf|5fzf]], [[5fzg|5fzg]], [[5fzh|5fzh]], [[5fzi|5fzi]], [[5fzk|5fzk]], [[5fzl|5fzl]], [[5fzm|5fzm]], [[5fzo|5fzo]]</td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fz6 OCA], [http://pdbe.org/5fz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fz6 RCSB], [http://www.ebi.ac.uk/pdbsum/5fz6 PDBsum]</td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Brennan, P E]]
[[Category: Burgess-Brown, N A]]
[[Category: Collins, P]]
[[Category: Delft, F Von]]
[[Category: Edwards, A M]]
[[Category: Gileadi, C]]
[[Category: Johansson, C]]
[[Category: Krojer, T]]
[[Category: Kupinska, K]]
[[Category: Nowak, R]]
[[Category: Oppermann, U]]
[[Category: Pearce, N]]
[[Category: Strain-Damerell, C]]
[[Category: Szykowska, A]]
[[Category: Talon, R]]
[[Category: Diamond i04-1]]
[[Category: Fragment screening]]
[[Category: Jarid1b]]
[[Category: Oxidoreductase]]
[[Category: Pandda]]
[[Category: Plu1]]
[[Category: Sgc]]
[[Category: Structural genomic]]