5fzw - Revision history

OCA at 10:09, 14 June 2023

OCA — Wed, 14 Jun 2023 10:09:14 GMT

←Older revision		Revision as of 10:09, 14 June 2023
Line 1:		Line 1:

	==High resolution solution NMR structure of the spider venom peptide U3- scytotoxin-Sth1h==		==High resolution solution NMR structure of the spider venom peptide U3- scytotoxin-Sth1h==
-	<StructureSection load='5fzw' size='340' side='right'caption='[[5fzw~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5fzw' size='340' side='right'caption='[[5fzw]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fzw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fzw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scytodes_thoracica Scytodes thoracica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FZW FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fzv\|5fzv]], [[5fzx\|5fzx]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzw OCA], [https://pdbe.org/5fzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fzw RCSB], [https://www.ebi.ac.uk/pdbsum/5fzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzw OCA], [~~http~~://pdbe.org/5fzw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fzw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fzw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzw ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/U31H_SCYTH U31H_SCYTH] Probable insect neurotoxin with ion channel impairing activity (Probable). Does not show activity on 45 human receptors from 9 families (5-hydroxytryptamine, adrenergic, dopamine, muscarinic, histamine, neurotransmitter, opioid, sigma, and gaba(A) receptors) (PubMed:27227898). In vivo, when mixed with U3-SYTX-Sth1a does not cause paralytic or lethal activity when injected into crickets (PubMed:27227898). It is noteworthy that crickets are evolutionarily distant from prey species (PubMed:27227898).<ref>PMID:27227898</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Loening, N M~~]]	+	[[Category: Scytodes thoracica]]
-	[[Category: ~~Ick]]~~	+	[[Category: Loening NM]]
-	~~[[Category: Spider venom peptide]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 06:32, 13 May 2020

OCA — Wed, 13 May 2020 06:32:45 GMT

←Older revision		Revision as of 06:32, 13 May 2020
Line 1:		Line 1:

	==High resolution solution NMR structure of the spider venom peptide U3- scytotoxin-Sth1h==		==High resolution solution NMR structure of the spider venom peptide U3- scytotoxin-Sth1h==
-	<StructureSection load='5fzw' size='340' side='right' caption='[[5fzw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5fzw' size='340' side='right'caption='[[5fzw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fzw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fzw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FZW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fzv\|5fzv]], [[5fzx\|5fzx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fzv\|5fzv]], [[5fzx\|5fzx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzw OCA], [http://pdbe.org/5fzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzw RCSB], [http://www.ebi.ac.uk/pdbsum/5fzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzw OCA], [http://pdbe.org/5fzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzw RCSB], [http://www.ebi.ac.uk/pdbsum/5fzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Loening, N M]]		[[Category: Loening, N M]]
	[[Category: Ick]]		[[Category: Ick]]
	[[Category: Spider venom peptide]]		[[Category: Spider venom peptide]]
	[[Category: Toxin]]		[[Category: Toxin]]

OCA at 10:35, 3 August 2017

OCA — Thu, 03 Aug 2017 10:35:10 GMT

←Older revision		Revision as of 10:35, 3 August 2017
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[5fzw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZW FirstGlance]. <br>		<table><tr><td colspan='2'>[[5fzw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fzv\|5fzv]], [[5fzx\|5fzx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fzv\|5fzv]], [[5fzx\|5fzx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzw OCA], [http://pdbe.org/5fzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzw RCSB], [http://www.ebi.ac.uk/pdbsum/5fzw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzw OCA], [http://pdbe.org/5fzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzw RCSB], [http://www.ebi.ac.uk/pdbsum/5fzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:23, 20 June 2016

OCA — Mon, 20 Jun 2016 15:23:52 GMT

←Older revision		Revision as of 15:23, 20 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fzw is ~~ON HOLD until Paper~~ Publication	+	==High resolution solution NMR structure of the spider venom peptide U3- scytotoxin-Sth1h==
		+	<StructureSection load='5fzw' size='340' side='right' caption='[[5fzw]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fzw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZW FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fzv\|5fzv]], [[5fzx\|5fzx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzw OCA], [http://pdbe.org/5fzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzw RCSB], [http://www.ebi.ac.uk/pdbsum/5fzw PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any peptide or protein from spiders of the Scytodidae family. Many venom peptides target neuronal ion channels or receptors. However, we have not been able to determine the target of these Scytodes peptides so we can only state with certainty the channels and receptors that they do not target.

-	~~Authors: Loening~~, N.M.	+	Characterization of Three Venom Peptides from the Spitting Spider Scytodes thoracica.,Ariki NK, Munoz LE, Armitage EL, Goodstein FR, George KG, Smith VL, Vetter I, Herzig V, King GF, Loening NM PLoS One. 2016 May 26;11(5):e0156291. doi: 10.1371/journal.pone.0156291., eCollection 2016. PMID:27227898<ref>PMID:27227898</ref>

-	~~Description: High resolution solution NMR structure~~ of the ~~spider venom peptide U3~~-~~scytotoxin~~-~~Sth1h~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Loening, N.M~~]]	+	<div class="pdbe-citations 5fzw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Loening, N M]]
		+	[[Category: Ick]]
		+	[[Category: Spider venom peptide]]
		+	[[Category: Toxin]]

OCA: Protected "5fzw" [edit=sysop:move=sysop]

OCA — Tue, 10 May 2016 23:16:50 GMT

Protected "5fzw" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:16, 10 May 2016

OCA: New page: '''Unreleased structure''' The entry 5fzw is ON HOLD until Paper Publication Authors: Loening, N.M. Description: High resolution solution NMR structure of the spider venom peptide U3-s...

OCA — Tue, 10 May 2016 23:16:49 GMT

New page: '''Unreleased structure''' The entry 5fzw is ON HOLD until Paper Publication Authors: Loening, N.M. Description: High resolution solution NMR structure of the spider venom peptide U3-s...

New page

'''Unreleased structure'''

The entry 5fzw is ON HOLD until Paper Publication

Authors: Loening, N.M.

Description: High resolution solution NMR structure of the spider venom peptide U3-scytotoxin-Sth1h
[[Category: Unreleased Structures]]
[[Category: Loening, N.M]]