5g0y - Revision history

OCA at 13:34, 26 July 2023

OCA — Wed, 26 Jul 2023 13:34:50 GMT

←Older revision		Revision as of 13:34, 26 July 2023
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	<StructureSection load='5g0y' size='340' side='right'caption='[[5g0y]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='5g0y' size='340' side='right'caption='[[5g0y]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g0y]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G0Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5G0Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g0y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G0Y FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.29Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5g0x\|5g0x]]~~, ~~[[5g10\|5g10]], [[5g11\|5g11]], [[5g12\|5g12]], [[5g13\|5g13]], [[5g17\|5g17]], [[5g1a\|5g1a]], [[5g1b\|5g1b]], [[5g1c\|5g1c]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5g0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g0y OCA], [~~http~~://pdbe.org/5g0y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5g0y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5g0y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5g0y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g0y OCA], [https://pdbe.org/5g0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g0y RCSB], [https://www.ebi.ac.uk/pdbsum/5g0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g0y ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HDAH_PSEAE HDAH_PSEAE] Probable protein deacetylase that catalyzes deacetylation of acetylated lysine residues. In vitro, exhibits high activity against artificial HDAC (histone deacetylase) substrates containing acetylated and trifluoroacetylated lysine residues. Is not able to deacetylate acetylated polyamines.<ref>PMID:26956223</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5g0y" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5g0y" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Histone deacetylase 3D structures\|Histone deacetylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Kraemer, A]]	+	[[Category: Kraemer A]]
-	[[Category: Meyer-Almes~~, F J~~]]	+	[[Category: Meyer-Almes FJ]]
-	[[Category: Yildiz, O]]	+	[[Category: Yildiz O]]
-	~~[[Category: Hdac]]~~	+
-	~~[[Category: Hdah]]~~	+
-	~~[[Category: Hdlp]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 06:34, 13 May 2020

OCA — Wed, 13 May 2020 06:34:13 GMT

←Older revision		Revision as of 06:34, 13 May 2020
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	==Pseudomonas aeruginosa HDAH unliganded.==		==Pseudomonas aeruginosa HDAH unliganded.==
-	<StructureSection load='5g0y' size='340' side='right' caption='[[5g0y]], [[Resolution\|resolution]] 2.29Å' scene=''>	+	<StructureSection load='5g0y' size='340' side='right'caption='[[5g0y]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g0y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G0Y OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5G0Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g0y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G0Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5G0Y FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g0x\|5g0x]], [[5g10\|5g10]], [[5g11\|5g11]], [[5g12\|5g12]], [[5g13\|5g13]], [[5g17\|5g17]], [[5g1a\|5g1a]], [[5g1b\|5g1b]], [[5g1c\|5g1c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g0x\|5g0x]], [[5g10\|5g10]], [[5g11\|5g11]], [[5g12\|5g12]], [[5g13\|5g13]], [[5g17\|5g17]], [[5g1a\|5g1a]], [[5g1b\|5g1b]], [[5g1c\|5g1c]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5g0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g0y OCA], [http://pdbe.org/5g0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g0y RCSB], [http://www.ebi.ac.uk/pdbsum/5g0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g0y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5g0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g0y OCA], [http://pdbe.org/5g0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g0y RCSB], [http://www.ebi.ac.uk/pdbsum/5g0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g0y ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pseae]]
	[[Category: Kraemer, A]]		[[Category: Kraemer, A]]
	[[Category: Meyer-Almes, F J]]		[[Category: Meyer-Almes, F J]]

OCA at 07:50, 9 March 2017

OCA — Thu, 09 Mar 2017 07:50:27 GMT

←Older revision		Revision as of 07:50, 9 March 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g0y OCA], [http://pdbe.org/5g0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g0y RCSB], [http://www.ebi.ac.uk/pdbsum/5g0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g0y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g0y OCA], [http://pdbe.org/5g0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g0y RCSB], [http://www.ebi.ac.uk/pdbsum/5g0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g0y ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Despite the recently growing interest in the acetylation of lysine residues by prokaryotic enzymes, the underlying biological function is still not well understood. Deacetylation is accomplished by proteins that belong to the histone deacetylase (HDAC) superfamily. In this report, we present the first crystal structure of PA3774, a histone deacetylase homologue from the human pathogen Pseudomonas aeruginosa that shares a high degree of homology with class IIb HDACs. We determined the crystal structure of the ligand-free enzyme and protein-ligand complexes with a trifluoromethylketone inhibitor and the reaction product acetate. Moreover, we produced loss of function mutants and determined the structure of the inhibitor-free PA3774H143A mutant, the inhibitor-free PA3774Y313F mutant, and the PA3774Y313F mutant in complex with the highly selective hydroxamate inhibitor PFSAHA. The overall structure reveals that the exceptionally long L1 loop mediates the formation of a tetramer composed of two "head-to-head" dimers. The distinctive dimer interface significantly confines the entrance area of the active site, suggesting a crucial role for substrate recognition and selectivity.
		+
		+	Crystal Structure of a Histone Deacetylase Homologue from Pseudomonas aeruginosa.,Kramer A, Wagner T, Yildiz O, Meyer-Almes FJ Biochemistry. 2016 Dec 13;55(49):6858-6868. Epub 2016 Nov 29. PMID:27951649<ref>PMID:27951649</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5g0y" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 02:11, 11 December 2016

OCA — Sun, 11 Dec 2016 02:11:23 GMT

←Older revision		Revision as of 02:11, 11 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5g0y is ~~ON HOLD~~	+	==Pseudomonas aeruginosa HDAH unliganded.==
-		+	<StructureSection load='5g0y' size='340' side='right' caption='[[5g0y]], [[Resolution\|resolution]] 2.29Å' scene=''>
-	~~Authors~~: ~~Kraemer~~, A., ~~Meyer~~-~~Almes~~, F.J., ~~Yildiz~~, O.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5g0y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G0Y FirstGlance]. <br>
-	~~Description~~: ~~Pseudomonas aeruginosa HDAH bound to hepes~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures]~~]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g0x\|5g0x]], [[5g10\|5g10]], [[5g11\|5g11]], [[5g12\|5g12]], [[5g13\|5g13]], [[5g17\|5g17]], [[5g1a\|5g1a]], [[5g1b\|5g1b]], [[5g1c\|5g1c]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g0y OCA], [http://pdbe.org/5g0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g0y RCSB], [http://www.ebi.ac.uk/pdbsum/5g0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g0y ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Kraemer, A]]		[[Category: Kraemer, A]]
		+	[[Category: Meyer-Almes, F J]]
	[[Category: Yildiz, O]]		[[Category: Yildiz, O]]
-	[[Category: ~~Meyer-Almes, F.J~~]]	+	[[Category: Hdac]]
		+	[[Category: Hdah]]
		+	[[Category: Hdlp]]
		+	[[Category: Hydrolase]]

OCA: Protected "5g0y" [edit=sysop:move=sysop]

OCA — Tue, 10 May 2016 23:19:46 GMT

Protected "5g0y" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:19, 10 May 2016

OCA: New page: '''Unreleased structure''' The entry 5g0y is ON HOLD Authors: Kraemer, A., Meyer-Almes, F.J., Yildiz, O. Description: Pseudomonas aeruginosa HDAH bound to hepes. [[Category: Unreleased...

OCA — Tue, 10 May 2016 23:19:45 GMT

New page: '''Unreleased structure''' The entry 5g0y is ON HOLD Authors: Kraemer, A., Meyer-Almes, F.J., Yildiz, O. Description: Pseudomonas aeruginosa HDAH bound to hepes. [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 5g0y is ON HOLD

Authors: Kraemer, A., Meyer-Almes, F.J., Yildiz, O.

Description: Pseudomonas aeruginosa HDAH bound to hepes.
[[Category: Unreleased Structures]]
[[Category: Kraemer, A]]
[[Category: Yildiz, O]]
[[Category: Meyer-Almes, F.J]]