5g21 - Revision history

OCA at 13:35, 26 July 2023

OCA — Wed, 26 Jul 2023 13:35:39 GMT

←Older revision		Revision as of 13:35, 26 July 2023
Line 3:		Line 3:
	<StructureSection load='5g21' size='340' side='right'caption='[[5g21]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5g21' size='340' side='right'caption='[[5g21]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g21]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G21 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5G21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g21]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G21 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=YN4:ETHYL+4-[(2-CYANOETHYL)SULFANYL]-6-{[6-(PIPERAZIN-1-YL)'>YN4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g1z\|5g1z]], [[5g20\|5g20]], [[5g22\|5g22]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=YN4:ETHYL+4-[(2-CYANOETHYL)SULFANYL]-6-{[6-(PIPERAZIN-1-YL)'>YN4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g21 OCA], [https://pdbe.org/5g21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g21 RCSB], [https://www.ebi.ac.uk/pdbsum/5g21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g21 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5g21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g21 OCA], [~~http~~://pdbe.org/5g21 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5g21 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5g21 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5g21 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).	+	[https://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bell~~, A S~~]]	+	[[Category: Leishmania major]]
-	[[Category: Brannigan~~, J A~~]]	+	[[Category: Bell AS]]
-	[[Category: Goncalves, V]]	+	[[Category: Brannigan JA]]
-	[[Category: Laporte, A]]	+	[[Category: Goncalves V]]
-	[[Category: Leatherbarrow~~, R J~~]]	+	[[Category: Laporte A]]
-	[[Category: Roberts~~, S M~~]]	+	[[Category: Leatherbarrow RJ]]
-	[[Category: Tate~~, E W~~]]	+	[[Category: Roberts SM]]
-	[[Category: Wilkinson~~, A J]]~~	+	[[Category: Tate EW]]
-	~~[[Category: Drug design]]~~	+	[[Category: Wilkinson AJ]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Malaria]]~~	+
-	~~[[Category: Myristoylation]]~~	+
-	~~[[Category: Quinoline]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:35, 13 May 2020

OCA — Wed, 13 May 2020 06:35:33 GMT

←Older revision		Revision as of 06:35, 13 May 2020
Line 1:		Line 1:

	==Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 26).==		==Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 26).==
-	<StructureSection load='5g21' size='340' side='right' caption='[[5g21]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='5g21' size='340' side='right'caption='[[5g21]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g21]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G21 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5G21 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g21]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G21 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5G21 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=YN4:ETHYL+4-[(2-CYANOETHYL)SULFANYL]-6-{[6-(PIPERAZIN-1-YL)'>YN4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=YN4:ETHYL+4-[(2-CYANOETHYL)SULFANYL]-6-{[6-(PIPERAZIN-1-YL)'>YN4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g1z\|5g1z]], [[5g20\|5g20]], [[5g22\|5g22]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g1z\|5g1z]], [[5g20\|5g20]], [[5g22\|5g22]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5g21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g21 OCA], [http://pdbe.org/5g21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g21 RCSB], [http://www.ebi.ac.uk/pdbsum/5g21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g21 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5g21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g21 OCA], [http://pdbe.org/5g21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g21 RCSB], [http://www.ebi.ac.uk/pdbsum/5g21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g21 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Glycylpeptide N-tetradecanoyltransferase]]		[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Bell, A S]]		[[Category: Bell, A S]]
	[[Category: Brannigan, J A]]		[[Category: Brannigan, J A]]

OCA at 10:28, 3 August 2017

OCA — Thu, 03 Aug 2017 10:28:29 GMT

←Older revision		Revision as of 10:28, 3 August 2017
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).		[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The parasite Plasmodium vivax is the most widely distributed cause of recurring malaria. N-Myristoyltransferase (NMT), an enzyme that catalyses the covalent attachment of myristate to the N-terminal glycine of substrate proteins, has been described as a potential target for the treatment of this disease. Herein, we report the synthesis and the structure-guided optimization of a series of quinolines with balanced activity against both Plasmodium vivax and Plasmodium falciparum N-myristoyltransferase (NMT).
		+
		+	Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.,Goncalves V, Brannigan JA, Laporte A, Bell AS, Roberts SM, Wilkinson AJ, Leatherbarrow RJ, Tate EW Medchemcomm. 2017 Jan 1;8(1):191-197. doi: 10.1039/c6md00531d. Epub 2016 Nov 11. PMID:28626547<ref>PMID:28626547</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5g21" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:34, 10 March 2017

OCA — Fri, 10 Mar 2017 17:34:48 GMT

←Older revision		Revision as of 17:34, 10 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5g21 ~~is ON HOLD until Paper Publication~~	+	==Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 26).==
-		+	<StructureSection load='5g21' size='340' side='right' caption='[[5g21]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~Authors~~: ~~Goncalves, V~~.~~, Brannigan, J~~.A., ~~Laporte~~, A., ~~Bell~~, A.S., ~~Roberts~~, S.M., ~~Wilkinson~~, A.J., ~~Leatherbarrow, R~~.J., ~~Tate, E~~.W.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5g21]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G21 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G21 FirstGlance]. <br>
-	~~Description~~: ~~Leishmania major~~ N-~~myristoyltransferase in complex with a quinoline inhibitor~~ (~~compound 26~~).	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=YN4:ETHYL+4-[(2-CYANOETHYL)SULFANYL]-6-{[6-(PIPERAZIN-1-YL)'>YN4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g1z\|5g1z]], [[5g20\|5g20]], [[5g22\|5g22]]</td></tr>
-	[[Category: ~~Wilkinson~~, A~~.J]]~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-	~~[[Category: Leatherbarrow, R.J~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g21 OCA], [http://pdbe.org/5g21 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g21 RCSB], [http://www.ebi.ac.uk/pdbsum/5g21 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g21 ProSAT]</span></td></tr>
-	[[Category: Brannigan, J.A]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glycylpeptide N-tetradecanoyltransferase]]
		+	[[Category: Bell, A S]]
		+	[[Category: Brannigan, J A]]
	[[Category: Goncalves, V]]		[[Category: Goncalves, V]]
-	[[Category: Roberts, S.M]]
-	[[Category: Tate, E.W]]
	[[Category: Laporte, A]]		[[Category: Laporte, A]]
-	[[Category: ~~Bell~~, A.S]]	+	[[Category: Leatherbarrow, R J]]
		+	[[Category: Roberts, S M]]
		+	[[Category: Tate, E W]]
		+	[[Category: Wilkinson, A J]]
		+	[[Category: Drug design]]
		+	[[Category: Inhibitor]]
		+	[[Category: Malaria]]
		+	[[Category: Myristoylation]]
		+	[[Category: Quinoline]]
		+	[[Category: Transferase]]

OCA at 13:02, 9 December 2016

OCA — Fri, 09 Dec 2016 13:02:35 GMT

←Older revision		Revision as of 13:02, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5g21 is ON HOLD	+	The entry 5g21 is ON HOLD until Paper Publication

	Authors: Goncalves, V., Brannigan, J.A., Laporte, A., Bell, A.S., Roberts, S.M., Wilkinson, A.J., Leatherbarrow, R.J., Tate, E.W.		Authors: Goncalves, V., Brannigan, J.A., Laporte, A., Bell, A.S., Roberts, S.M., Wilkinson, A.J., Leatherbarrow, R.J., Tate, E.W.

OCA: Protected "5g21" [edit=sysop:move=sysop]

OCA — Tue, 10 May 2016 23:23:00 GMT

Protected "5g21" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:23, 10 May 2016

OCA: New page: '''Unreleased structure''' The entry 5g21 is ON HOLD Authors: Goncalves, V., Brannigan, J.A., Laporte, A., Bell, A.S., Roberts, S.M., Wilkinson, A.J., Leatherbarrow, R.J., Tate, E.W. D...

OCA — Tue, 10 May 2016 23:22:59 GMT

New page: '''Unreleased structure''' The entry 5g21 is ON HOLD Authors: Goncalves, V., Brannigan, J.A., Laporte, A., Bell, A.S., Roberts, S.M., Wilkinson, A.J., Leatherbarrow, R.J., Tate, E.W. D...

New page

'''Unreleased structure'''

The entry 5g21 is ON HOLD

Authors: Goncalves, V., Brannigan, J.A., Laporte, A., Bell, A.S., Roberts, S.M., Wilkinson, A.J., Leatherbarrow, R.J., Tate, E.W.

Description: Leishmania major N-myristoyltransferase in complex with a quinoline inhibitor (compound 26).
[[Category: Unreleased Structures]]
[[Category: Wilkinson, A.J]]
[[Category: Leatherbarrow, R.J]]
[[Category: Brannigan, J.A]]
[[Category: Goncalves, V]]
[[Category: Roberts, S.M]]
[[Category: Tate, E.W]]
[[Category: Laporte, A]]
[[Category: Bell, A.S]]