5g4z - Revision history

OCA at 13:39, 26 July 2023

OCA — Wed, 26 Jul 2023 13:39:04 GMT

←Older revision		Revision as of 13:39, 26 July 2023
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	<StructureSection load='5g4z' size='340' side='right'caption='[[5g4z]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='5g4z' size='340' side='right'caption='[[5g4z]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g4z]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_19310 Atcc 19310~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G4Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5G4Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g4z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_syringae Pseudomonas syringae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G4Z FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene~~>, ~~<scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5g4y\|5g4y]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5g4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g4z OCA], [~~http~~://pdbe.org/5g4z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5g4z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5g4z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5g4z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g4z OCA], [https://pdbe.org/5g4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g4z RCSB], [https://www.ebi.ac.uk/pdbsum/5g4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g4z ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 19310]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brewster, J~~]]	+	[[Category: Pseudomonas syringae]]
-	[[Category: ~~Gerth, M L]]~~	+	[[Category: Brewster J]]
-	~~[[Category: McKellar,~~ J ~~L.O~~]]	+	[[Category: Gerth ML]]
-	[[Category: ~~Newman, J~~]]	+	[[Category: McKellar JLO]]
-	[[Category: ~~Peat, T S~~]]	+	[[Category: Newman J]]
-	[[Category: ~~Chemoreceptor~~]]	+	[[Category: Peat TS]]
-	[[Category: ~~Chemotaxis]]~~	+
-	~~[[Category: Ligand binding domain]]~~	+
-	~~[[Category: Methyl- accepting chemotaxis protein]]~~	+
-	~~[[Category: Pseudomonas syringae pv. actinidiae]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 13:02, 10 May 2019

OCA — Fri, 10 May 2019 13:02:49 GMT

←Older revision		Revision as of 13:02, 10 May 2019
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	==Structural basis for carboxylic acid recognition by a Cache chemosensory domain.==		==Structural basis for carboxylic acid recognition by a Cache chemosensory domain.==
-	<StructureSection load='5g4z' size='340' side='right' caption='[[5g4z]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='5g4z' size='340' side='right'caption='[[5g4z]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g4z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G4Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g4z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19310 Atcc 19310]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G4Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g4y\|5g4y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g4y\|5g4y]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 19310]]
		+	[[Category: Large Structures]]
	[[Category: Brewster, J]]		[[Category: Brewster, J]]
	[[Category: Gerth, M L]]		[[Category: Gerth, M L]]

OCA at 06:57, 5 April 2017

OCA — Wed, 05 Apr 2017 06:57:39 GMT

←Older revision		Revision as of 06:57, 5 April 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g4z OCA], [http://pdbe.org/5g4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g4z RCSB], [http://www.ebi.ac.uk/pdbsum/5g4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g4z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g4z OCA], [http://pdbe.org/5g4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g4z RCSB], [http://www.ebi.ac.uk/pdbsum/5g4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g4z ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Chemoreceptors enable bacteria to detect chemical signals in the environment and navigate towards niches that are favourable for survival. The sensor domains of chemoreceptors function as the input modules for chemotaxis systems, and provide sensory specificity by binding specific ligands. Cache-like domains are the most common extracellular sensor module in prokaryotes, however only a handful have been functionally or structurally characterised. Here, we have characterised a chemoreceptor Cache-like sensor domain (PscD-SD) from the plant pathogen Pseudomonas syringae pv. actinidiae (Psa). High-throughput fluorescence thermal shift assays, combined with isothermal thermal titration calorimetry, revealed that PscD-SD binds specifically to C2 (glycolate and acetate) and C3 (propionate and pyruvate) carboxylates. We solved the structure of PscD-SD in complex with propionate using X-ray crystallography. The structure reveals the key residues that comprise the ligand binding pocket and dictate the specificity of this sensor domain for C2 and C3 carboxylates. We also demonstrate that all four carboxylate ligands are chemoattractants for Psa, but only two of these (acetate and pyruvate) are utilisable carbon sources. This result suggests that in addition to guiding the bacteria towards nutrients, another possible role for carboxylate sensing is in locating potential sites of entry into the host plant.
		+
		+	Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae.,Brewster JL, McKellar JL, Finn TJ, Newman J, Peat TS, Gerth ML Sci Rep. 2016 Oct 13;6:35198. doi: 10.1038/srep35198. PMID:27734909<ref>PMID:27734909</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5g4z" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:42, 29 March 2017

OCA — Wed, 29 Mar 2017 13:42:48 GMT

←Older revision		Revision as of 13:42, 29 March 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5g4z ~~is ON HOLD until Paper Publication~~	+	==Structural basis for carboxylic acid recognition by a Cache chemosensory domain.==
-		+	<StructureSection load='5g4z' size='340' side='right' caption='[[5g4z]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~Authors~~: ~~Brewster, J~~.~~, McKellar, J~~.L.O.~~, Newman, J~~.~~, Peat, T~~.S.~~, Gerth, M~~.L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5g4z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G4Z FirstGlance]. <br>
-	~~Description~~: ~~Structural basis for carboxylic acid recognition by a Cache chemosensory domain.~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g4y\|5g4y]]</td></tr>
-	[[~~Category~~: ~~Gerth~~, M.L]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g4z OCA], [http://pdbe.org/5g4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g4z RCSB], [http://www.ebi.ac.uk/pdbsum/5g4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g4z ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Brewster, J]]		[[Category: Brewster, J]]
-	[[Category: ~~Mckellar~~, J.L.O]]	+	[[Category: Gerth, M L]]
-	[[Category: ~~Peat~~, T.S]]	+	[[Category: McKellar, J L.O]]
	[[Category: Newman, J]]		[[Category: Newman, J]]
		+	[[Category: Peat, T S]]
		+	[[Category: Chemoreceptor]]
		+	[[Category: Chemotaxis]]
		+	[[Category: Ligand binding domain]]
		+	[[Category: Methyl- accepting chemotaxis protein]]
		+	[[Category: Pseudomonas syringae pv. actinidiae]]
		+	[[Category: Signaling protein]]

OCA at 11:34, 9 September 2016

OCA — Fri, 09 Sep 2016 11:34:42 GMT

←Older revision		Revision as of 11:34, 9 September 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5g4z is ON HOLD	+	The entry 5g4z is ON HOLD until Paper Publication

	Authors: Brewster, J., McKellar, J.L.O., Newman, J., Peat, T.S., Gerth, M.L.		Authors: Brewster, J., McKellar, J.L.O., Newman, J., Peat, T.S., Gerth, M.L.

OCA: Protected "5g4z" [edit=sysop:move=sysop]

OCA — Wed, 01 Jun 2016 11:41:24 GMT

Protected "5g4z" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:41, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5g4z is ON HOLD Authors: Brewster, J., McKellar, J.L.O., Newman, J., Peat, T.S., Gerth, M.L. Description: Structural basis for carboxylic acid reco...

OCA — Wed, 01 Jun 2016 11:41:23 GMT

New page: '''Unreleased structure''' The entry 5g4z is ON HOLD Authors: Brewster, J., McKellar, J.L.O., Newman, J., Peat, T.S., Gerth, M.L. Description: Structural basis for carboxylic acid reco...

New page

'''Unreleased structure'''

The entry 5g4z is ON HOLD

Authors: Brewster, J., McKellar, J.L.O., Newman, J., Peat, T.S., Gerth, M.L.

Description: Structural basis for carboxylic acid recognition by a Cache chemosensory domain.
[[Category: Unreleased Structures]]
[[Category: Gerth, M.L]]
[[Category: Brewster, J]]
[[Category: Mckellar, J.L.O]]
[[Category: Peat, T.S]]
[[Category: Newman, J]]