5g6v - Revision history

OCA at 13:41, 26 July 2023

OCA — Wed, 26 Jul 2023 13:41:20 GMT

←Older revision		Revision as of 13:41, 26 July 2023
Line 3:		Line 3:
	<StructureSection load='5g6v' size='340' side='right'caption='[[5g6v]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5g6v' size='340' side='right'caption='[[5g6v]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g6v]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G6V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5G6V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g6v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G6V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=919:4-[4-({[3-TERT-BUTYL-1-(QUINOLIN-6-YL)-1H-PYRAZOL-5-YL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE'>919</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=919:4-[4-({[3-TERT-BUTYL-1-(QUINOLIN-6-YL)-1H-PYRAZOL-5-YL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE'>919</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5g6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g6v OCA], [~~http~~://pdbe.org/5g6v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5g6v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5g6v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5g6v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g6v OCA], [https://pdbe.org/5g6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g6v RCSB], [https://www.ebi.ac.uk/pdbsum/5g6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g6v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN]] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref>	+	[https://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cyclin-dependent kinase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H]]~~	+	[[Category: Arrowsmith CH]]
-	~~[[Category: Bartual, S Galan~~]]	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Bullock A]]
-	[[Category: Bullock, A]]	+	[[Category: Burgess-Brown N]]
-	[[Category: Burgess-Brown, N]]	+	[[Category: Dixon-Clarke SE]]
-	[[Category: ~~Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: ~~Dixon-Clarke, S E~~]]	+	[[Category: Elkins J]]
-	[[Category: ~~Edwards, A M~~]]	+	[[Category: Galan Bartual S]]
-	[[Category: ~~Elkins, J~~]]	+	[[Category: Heroven C]]
-	[[Category: Heroven, C]]	+	[[Category: Kopec J]]
-	[[Category: Kopec, J]]	+	[[Category: Mackenzie A]]
-	[[Category: Mackenzie, A]]	+	[[Category: Savitsky P]]
-	[[Category: Savitsky, P]]	+	[[Category: Tallant C]]
-	[[Category: Tallant, C]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Transferase~~]]	+

OCA at 06:41, 13 May 2020

OCA — Wed, 13 May 2020 06:41:12 GMT

←Older revision		Revision as of 06:41, 13 May 2020
Line 1:		Line 1:

	==Crystal structure of the PCTAIRE1 kinase in complex with inhibitor==		==Crystal structure of the PCTAIRE1 kinase in complex with inhibitor==
-	<StructureSection load='5g6v' size='340' side='right' caption='[[5g6v]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5g6v' size='340' side='right'caption='[[5g6v]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g6v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G6V OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5G6V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g6v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G6V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5G6V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=919:4-[4-({[3-TERT-BUTYL-1-(QUINOLIN-6-YL)-1H-PYRAZOL-5-YL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE'>919</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=919:4-[4-({[3-TERT-BUTYL-1-(QUINOLIN-6-YL)-1H-PYRAZOL-5-YL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE'>919</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5g6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g6v OCA], [http://pdbe.org/5g6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g6v RCSB], [http://www.ebi.ac.uk/pdbsum/5g6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g6v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5g6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g6v OCA], [http://pdbe.org/5g6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g6v RCSB], [http://www.ebi.ac.uk/pdbsum/5g6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g6v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN]] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref>		[[http://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN]] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref>
		+
		+	==See Also==
		+	*[[Cyclin-dependent kinase 3D structures\|Cyclin-dependent kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Cyclin-dependent kinase]]		[[Category: Cyclin-dependent kinase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bartual, S Galan]]		[[Category: Bartual, S Galan]]

OCA at 10:51, 10 December 2016

OCA — Sat, 10 Dec 2016 10:51:47 GMT

←Older revision		Revision as of 10:51, 10 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5g6v ~~is ON HOLD~~	+	==Crystal structure of the PCTAIRE1 kinase in complex with inhibitor==
-		+	<StructureSection load='5g6v' size='340' side='right' caption='[[5g6v]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~: ~~Dixon~~-~~Clarke, S~~.E.~~, Galan Bartual, S~~.~~, Elkins, J~~.~~, Savitsky, P~~.~~, Kopec, J~~., ~~Mackenzie~~, A.~~, Tallant, C~~., ~~Heroven, C~~.~~, Burgess~~-~~Brown, N~~.~~, von Delft, F~~., ~~Arrowsmith, C~~.H., ~~Edwards~~, A.M., ~~Bountra, C~~., ~~Bullock, A~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5g6v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G6V FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the PCTAIRE1~~ kinase in ~~complex with inhibitor~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=919:4-[4-({[3-TERT-BUTYL-1-(QUINOLIN-6-YL)-1H-PYRAZOL-5-YL]CARBAMOYL}AMINO)-3-FLUOROPHENOXY]-N-METHYLPYRIDINE-2-CARBOXAMIDE'>919</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g6v OCA], [http://pdbe.org/5g6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g6v RCSB], [http://www.ebi.ac.uk/pdbsum/5g6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g6v ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CDK16_HUMAN CDK16_HUMAN]] Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).<ref>PMID:22796189</ref> <ref>PMID:22798068</ref> <ref>PMID:22184064</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cyclin-dependent kinase]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bartual, S Galan]]
		+	[[Category: Bountra, C]]
	[[Category: Bullock, A]]		[[Category: Bullock, A]]
		+	[[Category: Burgess-Brown, N]]
		+	[[Category: Delft, F von]]
		+	[[Category: Dixon-Clarke, S E]]
		+	[[Category: Edwards, A M]]
	[[Category: Elkins, J]]		[[Category: Elkins, J]]
-	[[Category: ~~Burgess-Brown~~, N]]	+	[[Category: Heroven, C]]
-	[[Category: ~~Dixon-Clarke~~, ~~S.E]]~~	+	[[Category: Kopec, J]]
-	~~[[Category: Galan Bartual, S]]~~	+
-	~~[[Category: Bountra, C~~]]	+
	[[Category: Mackenzie, A]]		[[Category: Mackenzie, A]]
-	[[Category: ~~Arrowsmith~~, ~~C.H]]~~	+	[[Category: Savitsky, P]]
-	~~[[Category: Kopec, J]]~~	+
-	~~[[Category: Von Delft, F]]~~	+
-	~~[[Category: Edwards, A.M]]~~	+
-	~~[[Category: Heroven, C~~]]	+
	[[Category: Tallant, C]]		[[Category: Tallant, C]]
-	[[Category: ~~Savitsky, P~~]]	+	[[Category: Transferase]]

OCA: Protected "5g6v" [edit=sysop:move=sysop]

OCA — Fri, 09 Sep 2016 11:38:12 GMT

Protected "5g6v" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:38, 9 September 2016

OCA: New page: '''Unreleased structure''' The entry 5g6v is ON HOLD Authors: Dixon-Clarke, S.E., Galan Bartual, S., Elkins, J., Savitsky, P., Kopec, J., Mackenzie, A., Tallant, C., Heroven, C., Burges...

OCA — Fri, 09 Sep 2016 11:38:10 GMT

New page: '''Unreleased structure''' The entry 5g6v is ON HOLD Authors: Dixon-Clarke, S.E., Galan Bartual, S., Elkins, J., Savitsky, P., Kopec, J., Mackenzie, A., Tallant, C., Heroven, C., Burges...

New page

'''Unreleased structure'''

The entry 5g6v is ON HOLD

Authors: Dixon-Clarke, S.E., Galan Bartual, S., Elkins, J., Savitsky, P., Kopec, J., Mackenzie, A., Tallant, C., Heroven, C., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.

Description: Crystal structure of the PCTAIRE1 kinase in complex with inhibitor
[[Category: Unreleased Structures]]
[[Category: Bullock, A]]
[[Category: Elkins, J]]
[[Category: Burgess-Brown, N]]
[[Category: Dixon-Clarke, S.E]]
[[Category: Galan Bartual, S]]
[[Category: Bountra, C]]
[[Category: Mackenzie, A]]
[[Category: Arrowsmith, C.H]]
[[Category: Kopec, J]]
[[Category: Von Delft, F]]
[[Category: Edwards, A.M]]
[[Category: Heroven, C]]
[[Category: Tallant, C]]
[[Category: Savitsky, P]]