5ghb - Revision history

OCA at 11:31, 2 August 2023

OCA — Wed, 02 Aug 2023 11:31:24 GMT

←Older revision		Revision as of 11:31, 2 August 2023
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	==SOLUTION STRUCTURE OF LYS42 ACETYLATED HUMAN SUMO2==		==SOLUTION STRUCTURE OF LYS42 ACETYLATED HUMAN SUMO2==
-	<StructureSection load='5ghb' size='340' side='right' caption='[[5ghb~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5ghb' size='340' side='right'caption='[[5ghb]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ghb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GHB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GHB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ghb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GHB FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[2n1w\|2n1w]], [[5ghc\|5ghc]], [[5ghd\|5ghd]], [[5b7a\|5b7a]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">SUMO2, SMT3B, SMT3H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ghb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ghb OCA], [https://pdbe.org/5ghb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ghb RCSB], [https://www.ebi.ac.uk/pdbsum/5ghb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ghb ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ghb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ghb OCA], [~~http~~://pdbe.org/5ghb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ghb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ghb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ghb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>	+	[https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
		+
		+	==See Also==
		+	*[[SUMO 3D Structures\|SUMO 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Huang, T~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Naik, M~~ T]]	+	[[Category: Huang T]]
-	[[Category: Naik~~, N~~]]	+	[[Category: Naik MT]]
-	[[Category: ~~Shih, H~~]]	+	[[Category: Naik N]]
-	[[Category: ~~Acetylated protein]]~~	+	[[Category: Shih H]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Ubiquitin-like protein~~]]	+

OCA at 10:39, 16 November 2017

OCA — Thu, 16 Nov 2017 10:39:14 GMT

←Older revision		Revision as of 10:39, 16 November 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5ghb is ~~ON HOLD until Jun 19 2018~~	+	==SOLUTION STRUCTURE OF LYS42 ACETYLATED HUMAN SUMO2==
-		+	<StructureSection load='5ghb' size='340' side='right' caption='[[5ghb]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~: ~~Naik~~, M.T., ~~Naik~~, N., ~~Shih~~, H., ~~Huang, T~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ghb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GHB FirstGlance]. <br>
-	~~Description~~: ~~SOLUTION STRUCTURE OF LYS42 ACETYLATED HUMAN~~ SUMO2	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2n1w\|2n1w]], [[5ghc\|5ghc]], [[5ghd\|5ghd]], [[5b7a\|5b7a]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SUMO2, SMT3B, SMT3H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ghb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ghb OCA], [http://pdbe.org/5ghb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ghb RCSB], [http://www.ebi.ac.uk/pdbsum/5ghb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ghb ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Huang, T]]		[[Category: Huang, T]]
-	[[Category: Naik, M.T]]	+	[[Category: Naik, M T]]
	[[Category: Naik, N]]		[[Category: Naik, N]]
	[[Category: Shih, H]]		[[Category: Shih, H]]
		+	[[Category: Acetylated protein]]
		+	[[Category: Structural genomic]]
		+	[[Category: Ubiquitin-like protein]]

OCA at 06:35, 10 May 2017

OCA — Wed, 10 May 2017 06:35:16 GMT

←Older revision		Revision as of 06:35, 10 May 2017
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Huang, T]]		[[Category: Huang, T]]
-	[[Category: Shih, H]]
	[[Category: Naik, M.T]]		[[Category: Naik, M.T]]
	[[Category: Naik, N]]		[[Category: Naik, N]]
		+	[[Category: Shih, H]]

OCA at 08:54, 9 March 2017

OCA — Thu, 09 Mar 2017 08:54:24 GMT

←Older revision		Revision as of 08:54, 9 March 2017
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Huang, T]]		[[Category: Huang, T]]
		+	[[Category: Shih, H]]
	[[Category: Naik, M.T]]		[[Category: Naik, M.T]]
	[[Category: Naik, N]]		[[Category: Naik, N]]
-	[[Category: Shih, H]]

OCA: Protected "5ghb" [edit=sysop:move=sysop]

OCA — Tue, 12 Jul 2016 21:33:14 GMT

Protected "5ghb" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:33, 12 July 2016

OCA: New page: '''Unreleased structure''' The entry 5ghb is ON HOLD until Jun 19 2018 Authors: Naik, M.T., Naik, N., Shih, H., Huang, T. Description: SOLUTION STRUCTURE OF LYS42 ACETYLATED HUMAN SUMO...

OCA — Tue, 12 Jul 2016 21:33:13 GMT

New page: '''Unreleased structure''' The entry 5ghb is ON HOLD until Jun 19 2018 Authors: Naik, M.T., Naik, N., Shih, H., Huang, T. Description: SOLUTION STRUCTURE OF LYS42 ACETYLATED HUMAN SUMO...

New page

'''Unreleased structure'''

The entry 5ghb is ON HOLD until Jun 19 2018

Authors: Naik, M.T., Naik, N., Shih, H., Huang, T.

Description: SOLUTION STRUCTURE OF LYS42 ACETYLATED HUMAN SUMO2
[[Category: Unreleased Structures]]
[[Category: Huang, T]]
[[Category: Naik, M.T]]
[[Category: Naik, N]]
[[Category: Shih, H]]