5gix - Revision history

OCA at 11:32, 2 August 2023

OCA — Wed, 02 Aug 2023 11:32:45 GMT

←Older revision		Revision as of 11:32, 2 August 2023
Line 3:		Line 3:
	<StructureSection load='5gix' size='340' side='right'caption='[[5gix]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='5gix' size='340' side='right'caption='[[5gix]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gix]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5GIX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gix]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GIX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6WF:14-piperidin-1-yl-11-oxa-13$l^{3}-thia-15,16$l^{4}-diaza-12$l^{3}-ferratetracyclo[8.7.0.0^{2,7}.0^{12,16}]heptadeca-1(10),2(7),3,5,8,13,16-heptaene'>6WF</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.801Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5gix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gix OCA], [~~http~~://pdbe.org/5gix PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5gix RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5gix PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5gix ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6WF:14-piperidin-1-yl-11-oxa-13$l^{3}-thia-15,16$l^{4}-diaza-12$l^{3}-ferratetracyclo[8.7.0.0^{2,7}.0^{12,16}]heptadeca-1(10),2(7),3,5,8,13,16-heptaene'>6WF</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gix OCA], [https://pdbe.org/5gix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gix RCSB], [https://www.ebi.ac.uk/pdbsum/5gix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gix ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[~~http~~://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>	+	[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>	+	[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Qi, J]]	+	[[Category: Qi J]]
-	[[Category: Wang, T]]	+	[[Category: Wang T]]
-	[[Category: Yang, F]]	+	[[Category: Yang F]]
-	~~[[Category: Anticancer mechanism]]~~	+
-	~~[[Category: Ferric compound]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Therapeutic effect]]~~	+
-	~~[[Category: Tumor targeting~~]]	+

OCA at 06:44, 13 May 2020

OCA — Wed, 13 May 2020 06:44:15 GMT

←Older revision		Revision as of 06:44, 13 May 2020
Line 1:		Line 1:

	==Human serum albumin-Palmitic acid-Fe(Hn3piT)Cl2==		==Human serum albumin-Palmitic acid-Fe(Hn3piT)Cl2==
-	<StructureSection load='5gix' size='340' side='right' caption='[[5gix]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='5gix' size='340' side='right'caption='[[5gix]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gix]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GIX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gix]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GIX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6WF:14-piperidin-1-yl-11-oxa-13$l^{3}-thia-15,16$l^{4}-diaza-12$l^{3}-ferratetracyclo[8.7.0.0^{2,7}.0^{12,16}]heptadeca-1(10),2(7),3,5,8,13,16-heptaene'>6WF</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6WF:14-piperidin-1-yl-11-oxa-13$l^{3}-thia-15,16$l^{4}-diaza-12$l^{3}-ferratetracyclo[8.7.0.0^{2,7}.0^{12,16}]heptadeca-1(10),2(7),3,5,8,13,16-heptaene'>6WF</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5gix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gix OCA], [http://pdbe.org/5gix PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gix RCSB], [http://www.ebi.ac.uk/pdbsum/5gix PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gix ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gix OCA], [http://pdbe.org/5gix PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gix RCSB], [http://www.ebi.ac.uk/pdbsum/5gix PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gix ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5gix" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5gix" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Albumin 3D structures\|Albumin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Qi, J]]		[[Category: Qi, J]]
	[[Category: Wang, T]]		[[Category: Wang, T]]

OCA at 15:57, 20 October 2017

OCA — Fri, 20 Oct 2017 15:57:43 GMT

←Older revision		Revision as of 15:57, 20 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5gix is ~~ON HOLD~~	+	==Human serum albumin-Palmitic acid-Fe(Hn3piT)Cl2==
		+	<StructureSection load='5gix' size='340' side='right' caption='[[5gix]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5gix]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GIX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6WF:14-piperidin-1-yl-11-oxa-13$l^{3}-thia-15,16$l^{4}-diaza-12$l^{3}-ferratetracyclo[8.7.0.0^{2,7}.0^{12,16}]heptadeca-1(10),2(7),3,5,8,13,16-heptaene'>6WF</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gix OCA], [http://pdbe.org/5gix PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gix RCSB], [http://www.ebi.ac.uk/pdbsum/5gix PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gix ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To improve the selectivity, delivery, and activity of ferric (Fe) anticancer agents, we design prodrugs based on N-donor residues of the human serum albumin (HSA) carrier IIA subdomain. We synthesized six Fe(III) compounds derived from 2-hydroxy-1-naphthaldehyde thiosemicarbazone (7-12). HSA complex structure revealed that Fe compound binds to the hydrophobic cavity in the HSA IIA subdomain. Lys199 and His242 of HSA replace the two Cl atoms of Fe compound, coordinating with Fe(3+). In vivo data revealed that compound 12 and HSA-12 complex inhibit the growth of the liver tumor and that the HSA-12 complex has stronger targeting ability and therapeutic efficacy than compound 12 alone. In addition, our results have shown that compound 12 and HSA-12 complex induce Bel-7402 cell death possible by several mechanisms.

-	~~Authors~~:	+	Developing Anticancer Ferric Prodrugs Based on the N-Donor Residues of Human Serum Albumin Carrier IIA Subdomain.,Qi J, Gou Y, Zhang Y, Yang K, Chen S, Liu L, Wu X, Wang T, Zhang W, Yang F J Med Chem. 2016 Aug 25;59(16):7497-511. doi: 10.1021/acs.jmedchem.6b00509. Epub , 2016 Aug 8. PMID:27441502<ref>PMID:27441502</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5gix" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Qi, J]]
		+	[[Category: Wang, T]]
		+	[[Category: Yang, F]]
		+	[[Category: Anticancer mechanism]]
		+	[[Category: Ferric compound]]
		+	[[Category: Immune system]]
		+	[[Category: Therapeutic effect]]
		+	[[Category: Tumor targeting]]

OCA: Protected "5gix" [edit=sysop:move=sysop]

OCA — Tue, 12 Jul 2016 21:37:36 GMT

Protected "5gix" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:37, 12 July 2016

OCA: New page: '''Unreleased structure''' The entry 5gix is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Tue, 12 Jul 2016 21:37:34 GMT

New page: '''Unreleased structure''' The entry 5gix is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5gix is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]