5gjc - Revision history

OCA at 11:32, 2 August 2023

OCA — Wed, 02 Aug 2023 11:32:58 GMT

←Older revision		Revision as of 11:32, 2 August 2023
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	<StructureSection load='5gjc' size='340' side='right'caption='[[5gjc]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5gjc' size='340' side='right'caption='[[5gjc]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gjc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Zikv Zikv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GJC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5GJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gjc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GJC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE~~-~~5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.204Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5gjb\|5gjb]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gjc OCA], [~~http~~://pdbe.org/5gjc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5gjc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5gjc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5gjc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gjc OCA], [https://pdbe.org/5gjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gjc RCSB], [https://www.ebi.ac.uk/pdbsum/5gjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gjc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0U4DG08_ZIKV A0A0U4DG08_ZIKV]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	==See Also==		==See Also==
	*[[Helicase 3D structures\|Helicase 3D structures]]		*[[Helicase 3D structures\|Helicase 3D structures]]
		+	*[[Virus protease 3D structures\|Virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Zikv]]
-	[[Category: Chen, C]]
-	[[Category: Chi, H]]
-	[[Category: Ji, X Y]]
-	[[Category: Lou, H Q]]
-	[[Category: Lu, Z K]]
-	[[Category: Mu, Z Y]]
-	[[Category: Rao, Z H]]
-	[[Category: Tian, H L]]
-	[[Category: Wang, Z F]]
-	[[Category: Xie, W]]
-	[[Category: Yang, H T]]
-	[[Category: Yang, K L]]
-	[[Category: Yang, X Y]]
-	[[Category: Zhang, Z X]]
-	[[Category: Zhao, Q]]
-	[[Category: Atp]]
-	[[Category: Helicase]]
-	[[Category: Hydrolase]]
-	[[Category: Mn ion]]
	[[Category: Zika virus]]		[[Category: Zika virus]]
		+	[[Category: Chen C]]
		+	[[Category: Chi H]]
		+	[[Category: Ji XY]]
		+	[[Category: Lou HQ]]
		+	[[Category: Lu ZK]]
		+	[[Category: Mu ZY]]
		+	[[Category: Rao ZH]]
		+	[[Category: Tian HL]]
		+	[[Category: Wang ZF]]
		+	[[Category: Xie W]]
		+	[[Category: Yang HT]]
		+	[[Category: Yang KL]]
		+	[[Category: Yang XY]]
		+	[[Category: Zhang ZX]]
		+	[[Category: Zhao Q]]

OCA at 06:44, 13 May 2020

OCA — Wed, 13 May 2020 06:44:32 GMT

←Older revision		Revision as of 06:44, 13 May 2020
Line 1:		Line 1:

	==Zika virus NS3 helicase in complex with ATP==		==Zika virus NS3 helicase in complex with ATP==
-	<StructureSection load='5gjc' size='340' side='right' caption='[[5gjc]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5gjc' size='340' side='right'caption='[[5gjc]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gjc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GJC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GJC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gjc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zikv Zikv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GJC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GJC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gjb\|5gjb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gjb\|5gjb]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gjc OCA], [http://pdbe.org/5gjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gjc RCSB], [http://www.ebi.ac.uk/pdbsum/5gjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gjc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gjc OCA], [http://pdbe.org/5gjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gjc RCSB], [http://www.ebi.ac.uk/pdbsum/5gjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gjc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5gjc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5gjc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Helicase 3D structures\|Helicase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Zikv]]
	[[Category: Chen, C]]		[[Category: Chen, C]]
	[[Category: Chi, H]]		[[Category: Chi, H]]

OCA at 08:19, 10 August 2016

OCA — Wed, 10 Aug 2016 08:19:20 GMT

←Older revision		Revision as of 08:19, 10 August 2016
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gjc OCA], [http://pdbe.org/5gjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gjc RCSB], [http://www.ebi.ac.uk/pdbsum/5gjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gjc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gjc OCA], [http://pdbe.org/5gjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gjc RCSB], [http://www.ebi.ac.uk/pdbsum/5gjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gjc ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The recent explosive outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international concern. No specific vaccines or drugs are currently available to treat ZIKV infection. The ZIKV helicase, which plays a pivotal role in viral RNA replication, is an attractive target for therapy. We determined the crystal structures of ZIKV helicase-ATP-Mn2+ and ZIKV helicase-RNA. This is the first structure of any flavivirus helicase bound to ATP. Comparisons with related flavivirus helicases have shown that although the critical P-loop in the active site has variable conformations among different species, it adopts an identical mode to recognize ATP/Mn2+. The structure of ZIKV helicase-RNA has revealed that upon RNA binding, rotations of the motor domains can cause significant conformational changes. Strikingly, although ZIKV and dengue virus (DENV) apo-helicases share conserved residues for RNA binding, their different manners of motor domain rotations result in distinct individual modes for RNA recognition. It suggests that flavivirus helicases could have evolved a conserved engine to convert chemical energy from nucleoside triphosphate to mechanical energy for RNA unwinding, but different motor domain rotations result in variable RNA recognition modes to adapt to individual viral replication.
		+
		+	Structural basis of Zika virus helicase in recognizing its substrates.,Tian H, Ji X, Yang X, Zhang Z, Lu Z, Yang K, Chen C, Zhao Q, Chi H, Mu Z, Xie W, Wang Z, Lou H, Yang H, Rao Z Protein Cell. 2016 Jul 18. PMID:27430951<ref>PMID:27430951</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5gjc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:33, 26 July 2016

OCA — Tue, 26 Jul 2016 15:33:32 GMT

←Older revision		Revision as of 15:33, 26 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5gjc is ~~ON HOLD~~	+	==Zika virus NS3 helicase in complex with ATP==
-		+	<StructureSection load='5gjc' size='340' side='right' caption='[[5gjc]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5gjc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GJC FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gjb\|5gjb]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gjc OCA], [http://pdbe.org/5gjc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gjc RCSB], [http://www.ebi.ac.uk/pdbsum/5gjc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gjc ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, C]]
		+	[[Category: Chi, H]]
		+	[[Category: Ji, X Y]]
		+	[[Category: Lou, H Q]]
		+	[[Category: Lu, Z K]]
		+	[[Category: Mu, Z Y]]
		+	[[Category: Rao, Z H]]
		+	[[Category: Tian, H L]]
		+	[[Category: Wang, Z F]]
		+	[[Category: Xie, W]]
		+	[[Category: Yang, H T]]
		+	[[Category: Yang, K L]]
		+	[[Category: Yang, X Y]]
		+	[[Category: Zhang, Z X]]
		+	[[Category: Zhao, Q]]
		+	[[Category: Atp]]
		+	[[Category: Helicase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mn ion]]
		+	[[Category: Zika virus]]

OCA: Protected "5gjc" [edit=sysop:move=sysop]

OCA — Tue, 12 Jul 2016 21:38:46 GMT

Protected "5gjc" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:38, 12 July 2016

OCA: New page: '''Unreleased structure''' The entry 5gjc is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Tue, 12 Jul 2016 21:38:45 GMT

New page: '''Unreleased structure''' The entry 5gjc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5gjc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]