5glw - Revision history

OCA at 11:35, 2 August 2023

OCA — Wed, 02 Aug 2023 11:35:40 GMT

←Older revision		Revision as of 11:35, 2 August 2023
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	<StructureSection load='5glw' size='340' side='right'caption='[[5glw]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5glw' size='340' side='right'caption='[[5glw]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5glw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Parasitic_roundworm Parasitic roundworm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5GLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5glw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxascaris_leonina Toxascaris leonina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GLW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GAL:BETA~~-~~D-GALACTOSE'>GAL</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5gm0\|5gm0]]~~, ~~[[5glv\|5glv]], [[5glt\|5glt]], [[5glu\|5glu]], [[5glz\|5glz]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glw OCA], [~~http~~://pdbe.org/5glw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5glw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5glw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5glw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glw OCA], [https://pdbe.org/5glw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5glw RCSB], [https://www.ebi.ac.uk/pdbsum/5glw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5glw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1L1QJZ7_TOXLN A0A1L1QJZ7_TOXLN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Parasitic roundworm~~]]	+	[[Category: Toxascaris leonina]]
-	[[Category: Hwang~~, E Y~~]]	+	[[Category: Hwang EY]]
-	[[Category: Jang~~, S B]]~~	+	[[Category: Jang SB]]
-	~~[[Category: Anti-inflammation]]~~	+
-	~~[[Category: Carbohydrate]]~~	+
-	~~[[Category: Sugar binding protein]]~~	+
-	~~[[Category: Tl-galectin~~]]	+

OCA at 06:46, 13 May 2020

OCA — Wed, 13 May 2020 06:46:11 GMT

←Older revision		Revision as of 06:46, 13 May 2020
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	==Tl-gal with LacNAc==		==Tl-gal with LacNAc==
-	<StructureSection load='5glw' size='340' side='right' caption='[[5glw]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5glw' size='340' side='right'caption='[[5glw]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5glw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5glw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Parasitic_roundworm Parasitic roundworm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GLW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gm0\|5gm0]], [[5glv\|5glv]], [[5glt\|5glt]], [[5glu\|5glu]], [[5glz\|5glz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gm0\|5gm0]], [[5glv\|5glv]], [[5glt\|5glt]], [[5glu\|5glu]], [[5glz\|5glz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glw OCA], [http://pdbe.org/5glw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5glw RCSB], [http://www.ebi.ac.uk/pdbsum/5glw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5glw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glw OCA], [http://pdbe.org/5glw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5glw RCSB], [http://www.ebi.ac.uk/pdbsum/5glw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5glw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5glw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5glw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Galectin 3D structures\|Galectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Parasitic roundworm]]
	[[Category: Hwang, E Y]]		[[Category: Hwang, E Y]]
	[[Category: Jang, S B]]		[[Category: Jang, S B]]

OCA at 19:47, 9 December 2016

OCA — Fri, 09 Dec 2016 19:47:42 GMT

←Older revision		Revision as of 19:47, 9 December 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5glw is ~~ON HOLD until Paper~~ Publication	+	==Tl-gal with LacNAc==
		+	<StructureSection load='5glw' size='340' side='right' caption='[[5glw]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5glw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GLW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gm0\|5gm0]], [[5glv\|5glv]], [[5glt\|5glt]], [[5glu\|5glu]], [[5glz\|5glz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glw OCA], [http://pdbe.org/5glw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5glw RCSB], [http://www.ebi.ac.uk/pdbsum/5glw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5glw ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Toxascaris leonina galectin (Tl-gal) is a galectin-9 homologue protein isolated from an adult worm of the canine gastrointestinal nematode parasite, and Tl-gal-vaccinated challenge can inhibit inflammation in inflammatory bowel disease-induced mice. We determined the first X-ray structures of full-length Tl-gal complexes with carbohydrates (lactose, N-acetyllactosamine, lacto-N-tetraose, sialyllactose, and glucose). Bonds were formed on concave surfaces of both carbohydrate recognition domains (CRDs) in Tl-gal. All binding sites were found in the HXXXR and WGXEER motifs. Charged Arg61/Arg196 and Glu80/Glu215 on the conserved motif of Tl-gal N-terminal CRD and C-terminal CRD are critical amino acids for recognizing carbohydrate binding, and the residues can affect protein folding and structure. The polar amino acids His, Asn, and Trp are also important residues for the interaction with carbohydrates through hydrogen bonding. Hemagglutination activities of Tl-gal were inhibited by interactions with carbohydrates and mutations. We found that the mutation of Tl-gal (E80A/E215A) at the carbohydrate binding region induced protein aggregation and could be caused in many diseases. The short linker region between the N-terminal and C-terminal CRDs of Tl-gal was very stable against proteolysis and maintained its biological activity. This structural information is expected to elucidate the carbohydrate recognition mechanism of Tl-gal and improve our understanding of anti-inflammatory mediators and modulators of immune response.

-	~~Authors: Jang, S.B~~., Hwang, E.Y.	+	Structural Basis for Carbohydrate Recognition and Anti-inflammatory Modulation by Gastrointestinal Nematode Parasite Toxascaris leonina Galectin.,Hwang EY, Jeong MS, Park SK, Ha SC, Yu HS, Jang SB J Biol Chem. 2016 Dec 2;291(49):25326-25338. Epub 2016 Oct 14. PMID:27742836<ref>PMID:27742836</ref>

-	~~Description: Tl~~-~~gal with LacNAc~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Jang, S.B]]	+	<div class="pdbe-citations 5glw" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Hwang, E.Y~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hwang, E Y]]
		+	[[Category: Jang, S B]]
		+	[[Category: Anti-inflammation]]
		+	[[Category: Carbohydrate]]
		+	[[Category: Sugar binding protein]]
		+	[[Category: Tl-galectin]]

OCA at 11:32, 19 October 2016

OCA — Wed, 19 Oct 2016 11:32:36 GMT

←Older revision		Revision as of 11:32, 19 October 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5glw is ON HOLD	+	The entry 5glw is ON HOLD until Paper Publication

	Authors: Jang, S.B., Hwang, E.Y.		Authors: Jang, S.B., Hwang, E.Y.

OCA: Protected "5glw" [edit=sysop:move=sysop]

OCA — Tue, 26 Jul 2016 09:45:08 GMT

Protected "5glw" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:45, 26 July 2016

OCA: New page: '''Unreleased structure''' The entry 5glw is ON HOLD Authors: Jang, S.B., Hwang, E.Y. Description: Tl-gal with LacNAc Category: Unreleased Structures Category: Jang, S.B [[Cate...

OCA — Tue, 26 Jul 2016 09:45:06 GMT

New page: '''Unreleased structure''' The entry 5glw is ON HOLD Authors: Jang, S.B., Hwang, E.Y. Description: Tl-gal with LacNAc Category: Unreleased Structures Category: Jang, S.B [[Cate...

New page

'''Unreleased structure'''

The entry 5glw is ON HOLD

Authors: Jang, S.B., Hwang, E.Y.

Description: Tl-gal with LacNAc
[[Category: Unreleased Structures]]
[[Category: Jang, S.B]]
[[Category: Hwang, E.Y]]