5gne - Revision history

OCA at 11:37, 2 August 2023

OCA — Wed, 02 Aug 2023 11:37:22 GMT

←Older revision		Revision as of 11:37, 2 August 2023
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	==Crystal structure of LapB from Legionella pneumophila==		==Crystal structure of LapB from Legionella pneumophila==
-	<StructureSection load='5gne' size='340' side='right' caption='[[5gne]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5gne' size='340' side='right'caption='[[5gne]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gne]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Legph Legph~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GNE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GNE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SO4:SULFATE+ION'>SO4</scene~~>, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~lpg0032 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=272624 LEGPH])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5gne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gne OCA], [~~http~~://pdbe.org/5gne PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5gne RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5gne PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5gne ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gne OCA], [https://pdbe.org/5gne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gne RCSB], [https://www.ebi.ac.uk/pdbsum/5gne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gne ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5ZZH8_LEGPH Q5ZZH8_LEGPH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:

	==See Also==		==See Also==
-	*[[Aminopeptidase\|Aminopeptidase]]	+	*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Legph~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ge, H~~]]	+	[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
-	[[Category: ~~Zhang, N~~]]	+	[[Category: Ge H]]
-	[[Category: ~~Aminopeptidase]]~~	+	[[Category: Zhang N]]
-	~~[[Category: Autoinhibition]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Legionella pneumophila]]~~	+
-	~~[[Category: Pa domain~~]]	+

OCA at 08:21, 17 October 2018

OCA — Wed, 17 Oct 2018 08:21:14 GMT

←Older revision		Revision as of 08:21, 17 October 2018
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	</div>		</div>
	<div class="pdbe-citations 5gne" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5gne" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminopeptidase\|Aminopeptidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:33, 6 December 2017

OCA — Wed, 06 Dec 2017 07:33:18 GMT

←Older revision		Revision as of 07:33, 6 December 2017
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	<StructureSection load='5gne' size='340' side='right' caption='[[5gne]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5gne' size='340' side='right' caption='[[5gne]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gne]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GNE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GNE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lpg0032 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gne OCA], [http://pdbe.org/5gne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gne RCSB], [http://www.ebi.ac.uk/pdbsum/5gne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gne ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gne OCA], [http://pdbe.org/5gne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gne RCSB], [http://www.ebi.ac.uk/pdbsum/5gne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gne ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Legph]]
	[[Category: Ge, H]]		[[Category: Ge, H]]
	[[Category: Zhang, N]]		[[Category: Zhang, N]]

OCA at 03:58, 30 August 2017

OCA — Wed, 30 Aug 2017 03:58:09 GMT

←Older revision		Revision as of 03:58, 30 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5gne is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of LapB from Legionella pneumophila==
		+	<StructureSection load='5gne' size='340' side='right' caption='[[5gne]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5gne]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GNE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gne OCA], [http://pdbe.org/5gne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gne RCSB], [http://www.ebi.ac.uk/pdbsum/5gne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gne ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aminopeptidases are a group of exopeptidases that catalyze the removal of a wide range of N-terminal amino acid residues from peptides and proteins. They have many important commercial applications in the food industry. We determined the crystal structure of an aminopeptidase LapB from Legionella pneumophila. The overall structure reveals that the N-terminal protease-associated (PA) domain presents a new fold and shields the active site cavity of the conserved C-terminal peptidase domain. The steady-state kinetic analysis of LapB and the PA domain deletion mutant indicate that the PA domain inhibited enzyme activity of the peptidase domain. Interestingly, the activity of LapB was largely increased by various organic solvents such as ethanol, propanol, and methanol at the concentration of 60% (v/v). CD analysis provided evidence that organic solvents induce the PA domain conformational changes that eliminate the inhibition role. The unique properties indicate the application potential of LapB in the food processing industry.

-	~~Authors~~:	+	Crystal Structure and Biochemical Characterization of an Aminopeptidase LapB from Legionella pneumophila.,Zhang N, Yin S, Zhang W, Gong X, Zhang N, Fang K, Ge H J Agric Food Chem. 2017 Aug 17. doi: 10.1021/acs.jafc.7b02849. PMID:28776986<ref>PMID:28776986</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5gne" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ge, H]]
		+	[[Category: Zhang, N]]
		+	[[Category: Aminopeptidase]]
		+	[[Category: Autoinhibition]]
		+	[[Category: Hydrolase]]
		+	[[Category: Legionella pneumophila]]
		+	[[Category: Pa domain]]

OCA at 11:50, 9 September 2016

OCA — Fri, 09 Sep 2016 11:50:34 GMT

←Older revision		Revision as of 11:50, 9 September 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5gne is ON HOLD	+	The entry 5gne is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5gne" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2016 10:39:20 GMT

Protected "5gne" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:39, 27 July 2016

OCA: New page: '''Unreleased structure''' The entry 5gne is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Jul 2016 10:39:19 GMT

New page: '''Unreleased structure''' The entry 5gne is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5gne is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]