5gni - Revision history

OCA at 11:37, 2 August 2023

OCA — Wed, 02 Aug 2023 11:37:26 GMT

←Older revision		Revision as of 11:37, 2 August 2023
Line 3:		Line 3:
	<StructureSection load='5gni' size='340' side='right'caption='[[5gni]], [[Resolution\|resolution]] 3.01Å' scene=''>		<StructureSection load='5gni' size='340' side='right'caption='[[5gni]], [[Resolution\|resolution]] 3.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gni]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5GNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GNI FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PECAM1 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.008Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5gni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gni OCA], [~~http~~://pdbe.org/5gni PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5gni RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5gni PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5gni ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gni OCA], [https://pdbe.org/5gni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gni RCSB], [https://www.ebi.ac.uk/pdbsum/5gni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gni ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PECA1_HUMAN PECA1_HUMAN]] Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).<ref>PMID:12110892</ref> <ref>PMID:18388311</ref> <ref>PMID:19342684</ref>	+	[https://www.uniprot.org/uniprot/PECA1_HUMAN PECA1_HUMAN] Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).<ref>PMID:12110892</ref> <ref>PMID:18388311</ref> <ref>PMID:19342684</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hao, Q]]	+	[[Category: Hao Q]]
-	[[Category: Hu, M]]	+	[[Category: Hu M]]
-	[[Category: Liu, Q]]	+	[[Category: Liu Q]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell adhesion molecule]]~~	+
-	~~[[Category: Immunoglobulin-like domain]]~~	+
-	~~[[Category: Trans-homophilic dimer~~]]	+

OCA at 06:47, 13 May 2020

OCA — Wed, 13 May 2020 06:47:28 GMT

←Older revision		Revision as of 06:47, 13 May 2020
Line 1:		Line 1:

	==The crystal structure of PECAM-1 IgL1-2 trans-homophilic dimer==		==The crystal structure of PECAM-1 IgL1-2 trans-homophilic dimer==
-	<StructureSection load='5gni' size='340' side='right' caption='[[5gni]], [[Resolution\|resolution]] 3.01Å' scene=''>	+	<StructureSection load='5gni' size='340' side='right'caption='[[5gni]], [[Resolution\|resolution]] 3.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gni]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gni]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GNI FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5gni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gni OCA], [http://pdbe.org/5gni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gni RCSB], [http://www.ebi.ac.uk/pdbsum/5gni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gni ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PECAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gni OCA], [http://pdbe.org/5gni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gni RCSB], [http://www.ebi.ac.uk/pdbsum/5gni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gni ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Hao, Q]]		[[Category: Hao, Q]]
	[[Category: Hu, M]]		[[Category: Hu, M]]

OCA at 11:02, 1 February 2017

OCA — Wed, 01 Feb 2017 11:02:36 GMT

←Older revision		Revision as of 11:02, 1 February 2017
Line 8:		Line 8:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PECA1_HUMAN PECA1_HUMAN]] Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).<ref>PMID:12110892</ref> <ref>PMID:18388311</ref> <ref>PMID:19342684</ref>		[[http://www.uniprot.org/uniprot/PECA1_HUMAN PECA1_HUMAN]] Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).<ref>PMID:12110892</ref> <ref>PMID:18388311</ref> <ref>PMID:19342684</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cell adhesion involved in signal transduction, tissue integrity and pathogen infection is mainly mediated by cell adhesion molecules (CAM). One CAM member, platelet-endothelial-cell adhesion molecule-1 (PECAM-1), plays an important role in tight junction among endothelia cells, leukocyte trafficking, and immune response through its homophilic and heterophilic binding patterns. Both kinds of interactions, which lead to endogenous and exogenous signal transmission, are derived from extracellular immunoglobulin-like (IgL) domains and cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) of PECAM-1. To date, the mechanism of trans-homophilic interaction of PECAM-1 remains unclear. Here, we present the crystal structure of PECAM-1 IgL1-2 trans-homo dimer. Both IgL 1 and 2 adopt the classical Ig domain conformation comprised of two layers of beta-sheets possessing antiparallel beta-strands with each being anchored by a pair of cysteines forming a disulfide bond. The dimer interface includes hydrophobic and hydrophilic interactions. The Small-Angle X-ray Scattering (SAXS) envelope of PECAM-1 IgL1-6 supported such a dimer formation in solution. Cell adhesion assays on wildtype and mutant PECAM-1 further characterized the structural determinants in cell junction and communication.
		+
		+	Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion.,Hu M, Zhang H, Liu Q, Hao Q Sci Rep. 2016 Dec 13;6:38655. doi: 10.1038/srep38655. PMID:27958302<ref>PMID:27958302</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5gni" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:38, 22 December 2016

OCA — Thu, 22 Dec 2016 21:38:55 GMT

←Older revision		Revision as of 21:38, 22 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5gni is ~~ON HOLD~~	+	==The crystal structure of PECAM-1 IgL1-2 trans-homophilic dimer==
-		+	<StructureSection load='5gni' size='340' side='right' caption='[[5gni]], [[Resolution\|resolution]] 3.01Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5gni]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GNI FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gni OCA], [http://pdbe.org/5gni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gni RCSB], [http://www.ebi.ac.uk/pdbsum/5gni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gni ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PECA1_HUMAN PECA1_HUMAN]] Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).<ref>PMID:12110892</ref> <ref>PMID:18388311</ref> <ref>PMID:19342684</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hao, Q]]
		+	[[Category: Hu, M]]
		+	[[Category: Liu, Q]]
		+	[[Category: Zhang, H]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell adhesion molecule]]
		+	[[Category: Immunoglobulin-like domain]]
		+	[[Category: Trans-homophilic dimer]]

OCA: Protected "5gni" [edit=sysop:move=sysop]

OCA — Wed, 27 Jul 2016 10:39:42 GMT

Protected "5gni" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:39, 27 July 2016

OCA: New page: '''Unreleased structure''' The entry 5gni is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Jul 2016 10:39:40 GMT

New page: '''Unreleased structure''' The entry 5gni is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5gni is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]