5gqq - Revision history

OCA at 09:13, 20 March 2024

OCA — Wed, 20 Mar 2024 09:13:31 GMT

←Older revision		Revision as of 09:13, 20 March 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref>		[https://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	In the HIV-1 replication cycle, the endosomal sorting complex required for transport (ESCRT) machinery promotes viral budding and release in the late stages. In this process, the ESCRT proteins, ALIX and TSG101, are recruited through interactions with HIV-1 Gag p6. ALG-2, also known as PDCD6, interacts with both ALIX and TSG101 and bridges ESCRT-III and ESCRT-I. In this study, we show that ALG-2 affects HIV-1 production negatively at both the exogenous and endogenous levels. Through a yeast two-hybrid screen, we identified HEBP2 as the binding partner of ALG-2, and we solved the crystal structure of the ALG-2.HEBP2 complex. The function of ALG-2.HEBP2 complex in HIV-1 replication was further explored. ALG-2 inhibits HIV-1 production by affecting Gag expression and distribution, and HEBP2 might aid this process by tethering ALG-2 in the cytoplasm.
-
-	Structural and Functional Study of Apoptosis-linked Gene-2.Heme-binding Protein 2 Interactions in HIV-1 Production.,Ma J, Zhang X, Feng Y, Zhang H, Wang X, Zheng Y, Qiao W, Liu X J Biol Chem. 2016 Dec 23;291(52):26670-26685. doi: 10.1074/jbc.M116.752444. Epub , 2016 Oct 26. PMID:27784779<ref>PMID:27784779</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5gqq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:39, 2 August 2023

OCA — Wed, 02 Aug 2023 11:39:33 GMT

←Older revision		Revision as of 11:39, 2 August 2023
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	<StructureSection load='5gqq' size='340' side='right'caption='[[5gqq]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5gqq' size='340' side='right'caption='[[5gqq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gqq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GQQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5GQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gqq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GQQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gqq OCA], [~~http~~://pdbe.org/5gqq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5gqq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5gqq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5gqq ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gqq OCA], [https://pdbe.org/5gqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gqq RCSB], [https://www.ebi.ac.uk/pdbsum/5gqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN]] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref> [[http://www.uniprot.org/uniprot/PDCD6_HUMAN PDCD6_HUMAN]] Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.<ref>PMID:16132846</ref> <ref>PMID:19520058</ref>	+	[https://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:

	==See Also==		==See Also==
-	*[[Cell death protein\|Cell death protein]]	+	*[[Cell death protein 3D structures\|Cell death protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Feng, Y]]	+	[[Category: Feng Y]]
-	[[Category: Liu, X]]	+	[[Category: Liu X]]
-	[[Category: Ma, J]]	+	[[Category: Ma J]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Calcium ion]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Ef hand~~]]	+

OCA at 06:50, 13 May 2020

OCA — Wed, 13 May 2020 06:50:05 GMT

←Older revision		Revision as of 06:50, 13 May 2020
Line 1:		Line 1:

	==Structure of ALG-2/HEBP2 Complex==		==Structure of ALG-2/HEBP2 Complex==
-	<StructureSection load='5gqq' size='340' side='right' caption='[[5gqq]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5gqq' size='340' side='right'caption='[[5gqq]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gqq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GQQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gqq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GQQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gqq OCA], [http://pdbe.org/5gqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gqq RCSB], [http://www.ebi.ac.uk/pdbsum/5gqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gqq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gqq OCA], [http://pdbe.org/5gqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gqq RCSB], [http://www.ebi.ac.uk/pdbsum/5gqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gqq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5gqq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5gqq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cell death protein\|Cell death protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Feng, Y]]		[[Category: Feng, Y]]
	[[Category: Liu, X]]		[[Category: Liu, X]]

OCA at 01:15, 16 November 2017

OCA — Thu, 16 Nov 2017 01:15:59 GMT

←Older revision		Revision as of 01:15, 16 November 2017
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5gqq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5gqq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cell death protein\|Cell death protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:57, 17 August 2017

OCA — Thu, 17 Aug 2017 05:57:51 GMT

←Older revision		Revision as of 05:57, 17 August 2017
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN]] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref> [[http://www.uniprot.org/uniprot/PDCD6_HUMAN PDCD6_HUMAN]] Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.<ref>PMID:16132846</ref> <ref>PMID:19520058</ref>		[[http://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN]] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref> [[http://www.uniprot.org/uniprot/PDCD6_HUMAN PDCD6_HUMAN]] Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.<ref>PMID:16132846</ref> <ref>PMID:19520058</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the HIV-1 replication cycle, the endosomal sorting complex required for transport (ESCRT) machinery promotes viral budding and release in the late stages. In this process, the ESCRT proteins, ALIX and TSG101, are recruited through interactions with HIV-1 Gag p6. ALG-2, also known as PDCD6, interacts with both ALIX and TSG101 and bridges ESCRT-III and ESCRT-I. In this study, we show that ALG-2 affects HIV-1 production negatively at both the exogenous and endogenous levels. Through a yeast two-hybrid screen, we identified HEBP2 as the binding partner of ALG-2, and we solved the crystal structure of the ALG-2.HEBP2 complex. The function of ALG-2.HEBP2 complex in HIV-1 replication was further explored. ALG-2 inhibits HIV-1 production by affecting Gag expression and distribution, and HEBP2 might aid this process by tethering ALG-2 in the cytoplasm.
		+
		+	Structural and Functional Study of Apoptosis-linked Gene-2.Heme-binding Protein 2 Interactions in HIV-1 Production.,Ma J, Zhang X, Feng Y, Zhang H, Wang X, Zheng Y, Qiao W, Liu X J Biol Chem. 2016 Dec 23;291(52):26670-26685. doi: 10.1074/jbc.M116.752444. Epub , 2016 Oct 26. PMID:27784779<ref>PMID:27784779</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5gqq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cell death protein\|Cell death protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:28, 2 November 2016

OCA — Wed, 02 Nov 2016 18:28:04 GMT

←Older revision		Revision as of 18:28, 2 November 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5gqq is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Structure of ALG-2/HEBP2 Complex==
-		+	<StructureSection load='5gqq' size='340' side='right' caption='[[5gqq]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5gqq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GQQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GQQ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gqq OCA], [http://pdbe.org/5gqq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gqq RCSB], [http://www.ebi.ac.uk/pdbsum/5gqq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gqq ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HEBP2_HUMAN HEBP2_HUMAN]] Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin.<ref>PMID:17098234</ref> [[http://www.uniprot.org/uniprot/PDCD6_HUMAN PDCD6_HUMAN]] Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)-regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.<ref>PMID:16132846</ref> <ref>PMID:19520058</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Feng, Y]]
		+	[[Category: Liu, X]]
		+	[[Category: Ma, J]]
		+	[[Category: Zhang, H]]
		+	[[Category: Apoptosis]]
		+	[[Category: Calcium ion]]
		+	[[Category: Complex]]
		+	[[Category: Ef hand]]

OCA at 08:31, 21 September 2016

OCA — Wed, 21 Sep 2016 08:31:49 GMT

←Older revision		Revision as of 08:31, 21 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5gqq is ON HOLD	+	The entry 5gqq is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5gqq" [edit=sysop:move=sysop]

OCA — Fri, 09 Sep 2016 11:56:51 GMT

Protected "5gqq" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:56, 9 September 2016

OCA: New page: '''Unreleased structure''' The entry 5gqq is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Fri, 09 Sep 2016 11:56:49 GMT

New page: '''Unreleased structure''' The entry 5gqq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5gqq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]