5gzo - Revision history

OCA at 11:47, 2 August 2023

OCA — Wed, 02 Aug 2023 11:47:01 GMT

←Older revision		Revision as of 11:47, 2 August 2023
Line 3:		Line 3:
	<StructureSection load='5gzo' size='340' side='right'caption='[[5gzo]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='5gzo' size='340' side='right'caption='[[5gzo]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gzo]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Zikv Zikv~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GZO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5GZO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gzo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GZO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GZO FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~5gzn~~\|~~5gzn~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.755Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5gzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gzo OCA], [~~http~~://pdbe.org/5gzo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5gzo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5gzo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5gzo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gzo OCA], [https://pdbe.org/5gzo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gzo RCSB], [https://www.ebi.ac.uk/pdbsum/5gzo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gzo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1B0XTC8_ZIKV A0A1B0XTC8_ZIKV] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Zikv]]
-	[[Category: Bi, Y]]
-	[[Category: Cheng, G]]
-	[[Category: Dai, L]]
-	[[Category: Gao, G F]]
-	[[Category: Griffin, B]]
-	[[Category: He, J]]
-	[[Category: Kobinger, G]]
-	[[Category: Li, J]]
-	[[Category: Li, S]]
-	[[Category: Liang, M]]
-	[[Category: Liao, Y]]
-	[[Category: Liu, J]]
-	[[Category: Liu, S]]
-	[[Category: Liu, X]]
-	[[Category: Ma, T]]
-	[[Category: Peng, R]]
-	[[Category: Qi, J]]
-	[[Category: Qiu, X]]
-	[[Category: Shi, Y]]
-	[[Category: Song, J]]
-	[[Category: Tong, Z]]
-	[[Category: Wang, P]]
-	[[Category: Wang, Q]]
-	[[Category: Wong, G]]
-	[[Category: Xiong, Y]]
-	[[Category: Xu, X]]
-	[[Category: Yan, J]]
-	[[Category: Yang, H]]
-	[[Category: Yang, J]]
-	[[Category: Yuan, H]]
-	[[Category: Envelope protein]]
-	[[Category: Human neutralizing antibody]]
-	[[Category: Molecular determinant]]
-	[[Category: Viral protein-immune system complex]]
	[[Category: Zika virus]]		[[Category: Zika virus]]
		+	[[Category: Bi Y]]
		+	[[Category: Cheng G]]
		+	[[Category: Dai L]]
		+	[[Category: Gao GF]]
		+	[[Category: Griffin B]]
		+	[[Category: He J]]
		+	[[Category: Kobinger G]]
		+	[[Category: Li J]]
		+	[[Category: Li S]]
		+	[[Category: Liang M]]
		+	[[Category: Liao Y]]
		+	[[Category: Liu J]]
		+	[[Category: Liu S]]
		+	[[Category: Liu X]]
		+	[[Category: Ma T]]
		+	[[Category: Peng R]]
		+	[[Category: Qi J]]
		+	[[Category: Qiu X]]
		+	[[Category: Shi Y]]
		+	[[Category: Song J]]
		+	[[Category: Tong Z]]
		+	[[Category: Wang P]]
		+	[[Category: Wang Q]]
		+	[[Category: Wong G]]
		+	[[Category: Xiong Y]]
		+	[[Category: Xu X]]
		+	[[Category: Yan J]]
		+	[[Category: Yang H]]
		+	[[Category: Yang J]]
		+	[[Category: Yuan H]]

OCA at 06:47, 20 May 2020

OCA — Wed, 20 May 2020 06:47:40 GMT

←Older revision		Revision as of 06:47, 20 May 2020
Line 1:		Line 1:

	==Structure of neutralizing antibody bound to Zika envelope protein==		==Structure of neutralizing antibody bound to Zika envelope protein==
-	<StructureSection load='5gzo' size='340' side='right' caption='[[5gzo]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='5gzo' size='340' side='right'caption='[[5gzo]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gzo]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GZO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GZO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gzo]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Zikv Zikv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GZO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GZO FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gzn\|5gzn]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gzn\|5gzn]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5gzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gzo OCA], [http://pdbe.org/5gzo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gzo RCSB], [http://www.ebi.ac.uk/pdbsum/5gzo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gzo ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gzo OCA], [http://pdbe.org/5gzo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gzo RCSB], [http://www.ebi.ac.uk/pdbsum/5gzo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gzo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 5gzo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5gzo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
		+	[[Category: Zikv]]
	[[Category: Bi, Y]]		[[Category: Bi, Y]]
	[[Category: Cheng, G]]		[[Category: Cheng, G]]

OCA at 16:11, 18 January 2017

OCA — Wed, 18 Jan 2017 16:11:24 GMT

←Older revision		Revision as of 16:11, 18 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5gzo is ~~ON HOLD until Paper~~ Publication	+	==Structure of neutralizing antibody bound to Zika envelope protein==
		+	<StructureSection load='5gzo' size='340' side='right' caption='[[5gzo]], [[Resolution\|resolution]] 2.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5gzo]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GZO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GZO FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gzn\|5gzn]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gzo OCA], [http://pdbe.org/5gzo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gzo RCSB], [http://www.ebi.ac.uk/pdbsum/5gzo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gzo ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 2015-2016 outbreak of Zika virus (ZIKV) disease has affected many countries and is a major public health concern. ZIKV is associated with fetal microcephaly and neurological complications, and countermeasures are needed to treat and prevent ZIKV infection. We report the isolation of 13 specific human monoclonal antibodies from a single patient infected with ZIKV. Two of the isolated antibodies (Z23 and Z3L1) demonstrated potent ZIKV-specific neutralization in vitro without binding or neutralizing activity against strains 1 to 4 of dengue virus, the closest relative to ZIKV. These two antibodies provided postexposure protection to mice in vivo. Structural studies revealed that Z23 and Z3L1 bound to tertiary epitopes in envelope protein domain I, II, or III, indicating potential targets for ZIKV-specific therapy. Our results suggest the potential of antibody-based therapeutics and provide a structure-based rationale for the design of future ZIKV-specific vaccines.

-	~~Authors:~~ Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin~~, B.~~, Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao~~, G~~.F.	+	Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus.,Wang Q, Yang H, Liu X, Dai L, Ma T, Qi J, Wong G, Peng R, Liu S, Li J, Li S, Song J, Liu J, He J, Yuan H, Xiong Y, Liao Y, Li J, Yang J, Tong Z, Griffin BD, Bi Y, Liang M, Xu X, Qin C, Cheng G, Zhang X, Wang P, Qiu X, Kobinger G, Shi Y, Yan J, Gao GF Sci Transl Med. 2016 Dec 14;8(369):369ra179. PMID:27974667<ref>PMID:27974667</ref>

-	~~Description: Structure~~ of ~~neutralizing antibody bound to Zika envelope protein~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Liang~~, M]]	+	<div class="pdbe-citations 5gzo" style="background-color:#fffaf0;"></div>
-	[[Category: Li, S]]	+	== References ==
-	[[Category: ~~Peng~~, R]]	+	<references/>
-	[[Category: Gao, G.F]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Bi, Y]]
		+	[[Category: Cheng, G]]
		+	[[Category: Dai, L]]
		+	[[Category: Gao, G F]]
	[[Category: Griffin, B]]		[[Category: Griffin, B]]
		+	[[Category: He, J]]
		+	[[Category: Kobinger, G]]
	[[Category: Li, J]]		[[Category: Li, J]]
		+	[[Category: Li, S]]
		+	[[Category: Liang, M]]
		+	[[Category: Liao, Y]]
		+	[[Category: Liu, J]]
		+	[[Category: Liu, S]]
	[[Category: Liu, X]]		[[Category: Liu, X]]
-	[[Category: Qiu, X]]
-	[[Category: Yang, J]]
	[[Category: Ma, T]]		[[Category: Ma, T]]
-	[[Category: ~~Yang~~, H]]	+	[[Category: Peng, R]]
-	[[Category: ~~Liu~~, J]]	+	[[Category: Qi, J]]
		+	[[Category: Qiu, X]]
	[[Category: Shi, Y]]		[[Category: Shi, Y]]
		+	[[Category: Song, J]]
		+	[[Category: Tong, Z]]
	[[Category: Wang, P]]		[[Category: Wang, P]]
-	[[Category: ~~Cheng~~, ~~G]]~~	+	[[Category: Wang, Q]]
-	~~[[Category: Yuan, H]]~~	+
-	~~[[Category: Liu, S]]~~	+
-	~~[[Category: Kobinger, G~~]]	+
	[[Category: Wong, G]]		[[Category: Wong, G]]
-	[[Category: Dai, L]]
-	[[Category: Tong, Z]]
	[[Category: Xiong, Y]]		[[Category: Xiong, Y]]
-	[[Category: Song, J]]
-	[[Category: Wang, Q]]
-	[[Category: Yan, J]]
-	[[Category: He, J]]
-	[[Category: Liao, Y]]
	[[Category: Xu, X]]		[[Category: Xu, X]]
-	[[Category: Bi, Y]]	+	[[Category: Yan, J]]
-	[[Category: Qi, J]]	+	[[Category: Yang, H]]
		+	[[Category: Yang, J]]
		+	[[Category: Yuan, H]]
		+	[[Category: Envelope protein]]
		+	[[Category: Human neutralizing antibody]]
		+	[[Category: Molecular determinant]]
		+	[[Category: Viral protein-immune system complex]]
		+	[[Category: Zika virus]]

OCA at 10:52, 4 January 2017

OCA — Wed, 04 Jan 2017 10:52:04 GMT

←Older revision		Revision as of 10:52, 4 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5gzo is ON HOLD	+	The entry 5gzo is ON HOLD until Paper Publication

	Authors: Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.		Authors: Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.

OCA at 11:58, 19 October 2016

OCA — Wed, 19 Oct 2016 11:58:03 GMT

←Older revision		Revision as of 11:58, 19 October 2016
Line 3:		Line 3:
	The entry 5gzo is ON HOLD		The entry 5gzo is ON HOLD

-	Authors: Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H. , Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.	+	Authors: Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.

	Description: Structure of neutralizing antibody bound to Zika envelope protein		Description: Structure of neutralizing antibody bound to Zika envelope protein
Line 22:		Line 22:
	[[Category: Wang, P]]		[[Category: Wang, P]]
	[[Category: Cheng, G]]		[[Category: Cheng, G]]
		+	[[Category: Yuan, H]]
	[[Category: Liu, S]]		[[Category: Liu, S]]
	[[Category: Kobinger, G]]		[[Category: Kobinger, G]]
Line 27:		Line 28:
	[[Category: Dai, L]]		[[Category: Dai, L]]
	[[Category: Tong, Z]]		[[Category: Tong, Z]]
-	[[Category: ~~Yuan, H. ,~~ Xiong, Y]]	+	[[Category: Xiong, Y]]
	[[Category: Song, J]]		[[Category: Song, J]]
	[[Category: Wang, Q]]		[[Category: Wang, Q]]

OCA: Protected "5gzo" [edit=sysop:move=sysop]

OCA — Wed, 05 Oct 2016 16:22:16 GMT

Protected "5gzo" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:22, 5 October 2016

OCA: New page: '''Unreleased structure''' The entry 5gzo is ON HOLD Authors: Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J...

OCA — Wed, 05 Oct 2016 16:22:14 GMT

New page: '''Unreleased structure''' The entry 5gzo is ON HOLD Authors: Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J...

New page

'''Unreleased structure'''

The entry 5gzo is ON HOLD

Authors: Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan, H. , Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B., Bi, Y., Liang, M., Xu, X., Cheng, G., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan, J., Gao, G.F.

Description: Structure of neutralizing antibody bound to Zika envelope protein
[[Category: Unreleased Structures]]
[[Category: Liang, M]]
[[Category: Li, S]]
[[Category: Peng, R]]
[[Category: Gao, G.F]]
[[Category: Griffin, B]]
[[Category: Li, J]]
[[Category: Liu, X]]
[[Category: Qiu, X]]
[[Category: Yang, J]]
[[Category: Ma, T]]
[[Category: Yang, H]]
[[Category: Liu, J]]
[[Category: Shi, Y]]
[[Category: Wang, P]]
[[Category: Cheng, G]]
[[Category: Liu, S]]
[[Category: Kobinger, G]]
[[Category: Wong, G]]
[[Category: Dai, L]]
[[Category: Tong, Z]]
[[Category: Yuan, H. , Xiong, Y]]
[[Category: Song, J]]
[[Category: Wang, Q]]
[[Category: Yan, J]]
[[Category: He, J]]
[[Category: Liao, Y]]
[[Category: Xu, X]]
[[Category: Bi, Y]]
[[Category: Qi, J]]