5h29 - Revision history

OCA at 07:21, 9 August 2023

OCA — Wed, 09 Aug 2023 07:21:38 GMT

←Older revision		Revision as of 07:21, 9 August 2023
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	<StructureSection load='5h29' size='340' side='right'caption='[[5h29]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5h29' size='340' side='right'caption='[[5h29]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5h29]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H29 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5H29 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5h29]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H29 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRO:PROLINE'>PRO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o5q\|4o5q]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRO:PROLINE'>PRO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5h29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h29 OCA], [~~http~~://pdbe.org/5h29 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5h29 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5h29 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5h29 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h29 OCA], [https://pdbe.org/5h29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h29 RCSB], [https://www.ebi.ac.uk/pdbsum/5h29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h29 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q830N9_ENTFA Q830N9_ENTFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Enterococcus faecalis V583]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Balakrishna~~, A M~~]]	+	[[Category: Balakrishna AM]]
-	[[Category: Gruber, G]]	+	[[Category: Gruber G]]
-	[[Category: Kwang~~, T Y]]~~	+	[[Category: Kwang TY]]
-	~~[[Category: Electron donor]]~~	+
-	~~[[Category: Fad binding]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Thioredoxin fold~~]]	+

OCA at 06:50, 20 May 2020

OCA — Wed, 20 May 2020 06:50:03 GMT

←Older revision		Revision as of 06:50, 20 May 2020
Line 1:		Line 1:

	==Crystal Structure of the NTD_N/C domain of Alkylhydroperoxide Reductase AhpF from Enterococcus Faecalis (V583)==		==Crystal Structure of the NTD_N/C domain of Alkylhydroperoxide Reductase AhpF from Enterococcus Faecalis (V583)==
-	<StructureSection load='5h29' size='340' side='right' caption='[[5h29]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5h29' size='340' side='right'caption='[[5h29]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5h29]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H29 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5H29 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5h29]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H29 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5H29 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRO:PROLINE'>PRO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRO:PROLINE'>PRO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o5q\|4o5q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o5q\|4o5q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5h29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h29 OCA], [http://pdbe.org/5h29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h29 RCSB], [http://www.ebi.ac.uk/pdbsum/5h29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h29 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5h29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h29 OCA], [http://pdbe.org/5h29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h29 RCSB], [http://www.ebi.ac.uk/pdbsum/5h29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h29 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Balakrishna, A M]]		[[Category: Balakrishna, A M]]
	[[Category: Gruber, G]]		[[Category: Gruber, G]]

OCA at 07:37, 22 November 2017

OCA — Wed, 22 Nov 2017 07:37:03 GMT

←Older revision		Revision as of 07:37, 22 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5h29 is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of the NTD_N/C domain of Alkylhydroperoxide Reductase AhpF from Enterococcus Faecalis (V583)==
		+	<StructureSection load='5h29' size='340' side='right' caption='[[5h29]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5h29]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H29 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRO:PROLINE'>PRO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o5q\|4o5q]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h29 OCA], [http://pdbe.org/5h29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h29 RCSB], [http://www.ebi.ac.uk/pdbsum/5h29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h29 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ability of the vancomycin-resistant Enterococcus faecalis (V583) to restore redox homeostasis via antioxidant defense mechanism is of importance, and knowledge into this defense is essential to understand its antibiotic-resistance and survival in hosts. The flavoprotein disulfide reductase AhpR, composed of the subunits AhpC and AhpF, represents one such vital part. Circular permutation was found to be a feature of the AhpF protein family. E. faecalis (V583) AhpF (EfAhpF) appears to be a representative of a minor subclass of this family, the typically N-terminal two-fold thioredoxin-like domain (NTD_N/C) is located at the C-terminus, whereas the pyridine nucleotide-disulfide oxidoreductase domain is encoded in the N-terminal part of its sequence. In EfAhpF, these two domains are connected via an unusually long linker region providing optimal communication between both domains. EfAhpF forms a dimer in solution similar to Escherichia coli AhpF. The crystallographic 2.3A resolution structure of the NTD_N/C domain reveals a unique loop-helix stretch (409ILKDTEPAKELLYGIEKM426) not present in homologue domains of other prokaryotic AhpFs. Deletion of the unique 415PAKELLY421-helix or of 415PAKELL420 affects protein stability or attenuates peroxidase activity. Furthermore, mutation of Y421 is described to be essential for E. faecalis AhpF's optimal NADH-oxidative activity.

-	~~Authors~~:	+	Novel insights into the vancomycin-resistant Enterococcus faecalis (V583) alkylhydroperoxide reductase subunit F.,Toh YK, Balakrishna AM, Manimekalai MSS, Chionh BB, Seetharaman RRC, Eisenhaber F, Eisenhaber B, Gruber G Biochim Biophys Acta. 2017 Dec;1861(12):3201-3214. doi:, 10.1016/j.bbagen.2017.09.011. Epub 2017 Sep 19. PMID:28935609<ref>PMID:28935609</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5h29" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Balakrishna, A M]]
		+	[[Category: Gruber, G]]
		+	[[Category: Kwang, T Y]]
		+	[[Category: Electron donor]]
		+	[[Category: Fad binding]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Thioredoxin fold]]

OCA at 13:14, 26 October 2016

OCA — Wed, 26 Oct 2016 13:14:49 GMT

←Older revision		Revision as of 13:14, 26 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5h29 is ON HOLD	+	The entry 5h29 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5h29" [edit=sysop:move=sysop]

OCA — Wed, 19 Oct 2016 12:04:20 GMT

Protected "5h29" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:04, 19 October 2016

OCA: New page: '''Unreleased structure''' The entry 5h29 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 19 Oct 2016 12:04:19 GMT

New page: '''Unreleased structure''' The entry 5h29 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5h29 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]