5h6r - Revision history

OCA at 07:25, 9 August 2023

OCA — Wed, 09 Aug 2023 07:25:28 GMT

←Older revision		Revision as of 07:25, 9 August 2023
Line 1:		Line 1:

	==Crystal structure of LSD1-CoREST in complex with peptide 13==		==Crystal structure of LSD1-CoREST in complex with peptide 13==
-	<StructureSection load='5h6r' size='340' side='right' caption='[[5h6r]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5h6r' size='340' side='right'caption='[[5h6r]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5h6r]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H6R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5H6R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5h6r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H6R FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~HSE~~:L-~~HOMOSERINE~~'>~~HSE~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class="sblockDat">[[5h6q\|5h6q]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h6r OCA], [https://pdbe.org/5h6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h6r RCSB], [https://www.ebi.ac.uk/pdbsum/5h6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h6r ProSAT]</span></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">KDM1A, AOF2, KDM1, KIAA0601, LSD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RCOR1, KIAA0071, RCOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5h6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h6r OCA], [~~http~~://pdbe.org/5h6r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5h6r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5h6r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5h6r ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN]] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref> [[http://www.uniprot.org/uniprot/RCOR1_HUMAN RCOR1_HUMAN]] Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.<ref>PMID:11516394</ref> <ref>PMID:11171972</ref> <ref>PMID:12032298</ref> <ref>PMID:12399542</ref> <ref>PMID:12493763</ref> <ref>PMID:16140033</ref> <ref>PMID:16079794</ref>	+	[https://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5h6r" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5h6r" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lysine-specific histone demethylase 3D structures\|Lysine-specific histone demethylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Amano, Y]]	+	[[Category: Large Structures]]
-	[[Category: Higuchi, T]]	+	[[Category: Amano Y]]
-	[[Category: Kkuchi, M]]	+	[[Category: Higuchi T]]
-	[[Category: Sato, S]]	+	[[Category: Kkuchi M]]
-	[[Category: Umehara, T]]	+	[[Category: Sato S]]
-	[[Category: Umezawa, N]]	+	[[Category: Umehara T]]
-	[[Category: Yokoyama, S]]	+	[[Category: Umezawa N]]
-	~~[[Category: Amine oxidase]]~~	+	[[Category: Yokoyama S]]
-	~~[[Category: Chromatin]]~~	+
-	~~[[Category: Corepressor]]~~	+
-	~~[[Category: Demethylase]]~~	+
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Histone]]~~	+
-	~~[[Category: Oxidoreductase-transcription-inhibitor complex~~]]	+

OCA at 07:35, 6 December 2017

OCA — Wed, 06 Dec 2017 07:35:06 GMT

←Older revision		Revision as of 07:35, 6 December 2017
Line 3:		Line 3:
	<StructureSection load='5h6r' size='340' side='right' caption='[[5h6r]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5h6r' size='340' side='right' caption='[[5h6r]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5h6r]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H6R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5h6r]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H6R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5h6q\|5h6q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5h6q\|5h6q]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KDM1A, AOF2, KDM1, KIAA0601, LSD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RCOR1, KIAA0071, RCOR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h6r OCA], [http://pdbe.org/5h6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h6r RCSB], [http://www.ebi.ac.uk/pdbsum/5h6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h6r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h6r OCA], [http://pdbe.org/5h6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h6r RCSB], [http://www.ebi.ac.uk/pdbsum/5h6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h6r ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Amano, Y]]		[[Category: Amano, Y]]
	[[Category: Higuchi, T]]		[[Category: Higuchi, T]]

OCA at 11:36, 12 April 2017

OCA — Wed, 12 Apr 2017 11:36:08 GMT

←Older revision		Revision as of 11:36, 12 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5h6r is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of LSD1-CoREST in complex with peptide 13==
		+	<StructureSection load='5h6r' size='340' side='right' caption='[[5h6r]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5h6r]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H6R FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5h6q\|5h6q]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h6r OCA], [http://pdbe.org/5h6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h6r RCSB], [http://www.ebi.ac.uk/pdbsum/5h6r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h6r ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KDM1A_HUMAN KDM1A_HUMAN]] Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.<ref>PMID:12032298</ref> <ref>PMID:15620353</ref> <ref>PMID:16079795</ref> <ref>PMID:17805299</ref> <ref>PMID:20228790</ref> [[http://www.uniprot.org/uniprot/RCOR1_HUMAN RCOR1_HUMAN]] Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.<ref>PMID:11516394</ref> <ref>PMID:11171972</ref> <ref>PMID:12032298</ref> <ref>PMID:12399542</ref> <ref>PMID:12493763</ref> <ref>PMID:16140033</ref> <ref>PMID:16079794</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lysine-specific demethylase 1 (LSD1/KDM1A) is a flavoenzyme demethylase, which removes mono- and dimethyl groups from histone H3 Lys4 (H3K4) or Lys9 (H3K9) in complexes with several nuclear proteins. Since LSD1 is implicated in the tumorigenesis and progression of various cancers, LSD1-specific inhibitors are considered as potential anti-cancer agents. A modified H3 peptide with substitution of Lys4 to Met [H3K4M] is already known to be a potent competitive inhibitor of LSD1. In this study, we synthesized a series of H3K4M peptide derivatives and evaluated their LSD1-inhibitory activities in vitro. We found that substitutions of the N-terminal amino acid with amino acids having a larger side chain were generally not tolerated, but substitution of Ala1 to Ser unexpectedly resulted in more potent inhibitory activity toward LSD1. X-ray crystallographic analysis of H3K4M derivatives bound to the LSD1.CoREST complex revealed the presence of additional hydrogen bonding between the N-terminal Ser residue of the H3 peptide derivative and LSD1. The present structural and biochemical findings will be helpful for obtaining more potent peptidic inhibitors of LSD1.

-	~~Authors: Kkuchi, M~~., Amano, Y., ~~Sato~~, S., Yokoyama, S., ~~Umezawa~~, N., Higuchi, T., ~~Umehara, T~~.	+	Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.,Amano Y, Kikuchi M, Sato S, Yokoyama S, Umehara T, Umezawa N, Higuchi T Bioorg Med Chem. 2017 May 1;25(9):2617-2624. doi: 10.1016/j.bmc.2017.03.016. Epub, 2017 Mar 9. PMID:28336409<ref>PMID:28336409</ref>

-	~~Description: Crystal structure~~ of ~~LSD1-CoREST in complex with peptide 13~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5h6r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Amano, Y]]		[[Category: Amano, Y]]
-	[[Category: Umezawa, N]]
-	[[Category: Kkuchi, M]]
	[[Category: Higuchi, T]]		[[Category: Higuchi, T]]
		+	[[Category: Kkuchi, M]]
	[[Category: Sato, S]]		[[Category: Sato, S]]
	[[Category: Umehara, T]]		[[Category: Umehara, T]]
		+	[[Category: Umezawa, N]]
	[[Category: Yokoyama, S]]		[[Category: Yokoyama, S]]
		+	[[Category: Amine oxidase]]
		+	[[Category: Chromatin]]
		+	[[Category: Corepressor]]
		+	[[Category: Demethylase]]
		+	[[Category: Fad]]
		+	[[Category: Histone]]
		+	[[Category: Oxidoreductase-transcription-inhibitor complex]]

OCA at 09:27, 9 March 2017

OCA — Thu, 09 Mar 2017 09:27:20 GMT

←Older revision		Revision as of 09:27, 9 March 2017
Line 11:		Line 11:
	[[Category: Kkuchi, M]]		[[Category: Kkuchi, M]]
	[[Category: Higuchi, T]]		[[Category: Higuchi, T]]
		+	[[Category: Sato, S]]
	[[Category: Umehara, T]]		[[Category: Umehara, T]]
	[[Category: Yokoyama, S]]		[[Category: Yokoyama, S]]
-	[[Category: Sato, S]]

OCA at 11:00, 2 January 2017

OCA — Mon, 02 Jan 2017 11:00:20 GMT

←Older revision		Revision as of 11:00, 2 January 2017
Line 5:		Line 5:
	Authors: Kkuchi, M., Amano, Y., Sato, S., Yokoyama, S., Umezawa, N., Higuchi, T., Umehara, T.		Authors: Kkuchi, M., Amano, Y., Sato, S., Yokoyama, S., Umezawa, N., Higuchi, T., Umehara, T.

-	Description: Crystal structure of LSD1-~~COREST~~ in complex with a peptide 13	+	Description: Crystal structure of LSD1-CoREST in complex with peptide 13
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Amano, Y]]		[[Category: Amano, Y]]

OCA: Protected "5h6r" [edit=sysop:move=sysop]

OCA — Fri, 09 Dec 2016 13:48:42 GMT

Protected "5h6r" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:48, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5h6r is ON HOLD until Paper Publication Authors: Kkuchi, M., Amano, Y., Sato, S., Yokoyama, S., Umezawa, N., Higuchi, T., Umehara, T. Description: ...

OCA — Fri, 09 Dec 2016 13:48:41 GMT

New page: '''Unreleased structure''' The entry 5h6r is ON HOLD until Paper Publication Authors: Kkuchi, M., Amano, Y., Sato, S., Yokoyama, S., Umezawa, N., Higuchi, T., Umehara, T. Description: ...

New page

'''Unreleased structure'''

The entry 5h6r is ON HOLD until Paper Publication

Authors: Kkuchi, M., Amano, Y., Sato, S., Yokoyama, S., Umezawa, N., Higuchi, T., Umehara, T.

Description: Crystal structure of LSD1-COREST in complex with a peptide 13
[[Category: Unreleased Structures]]
[[Category: Amano, Y]]
[[Category: Umezawa, N]]
[[Category: Kkuchi, M]]
[[Category: Higuchi, T]]
[[Category: Umehara, T]]
[[Category: Yokoyama, S]]
[[Category: Sato, S]]