5h9l - Revision history

OCA at 07:28, 9 August 2023

OCA — Wed, 09 Aug 2023 07:28:06 GMT

←Older revision		Revision as of 07:28, 9 August 2023
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	<StructureSection load='5h9l' size='340' side='right'caption='[[5h9l]], [[Resolution\|resolution]] 1.37Å' scene=''>		<StructureSection load='5h9l' size='340' side='right'caption='[[5h9l]], [[Resolution\|resolution]] 1.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5h9l]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Rhopr Rhopr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5H9L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5h9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H9L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EAH:(5S,7E,9E,11Z,14Z)-5-HYDROXYICOSA-7,9,11,14-TETRAENOIC+ACID'>EAH</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.37Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5h9n\|5h9n]], [[5ha0\|5ha0]], [[5hae\|5hae]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EAH:(5S,7E,9E,11Z,14Z)-5-HYDROXYICOSA-7,9,11,14-TETRAENOIC+ACID'>EAH</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5h9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9l OCA], [~~http~~://pdbe.org/5h9l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5h9l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5h9l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9l ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9l OCA], [https://pdbe.org/5h9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h9l RCSB], [https://www.ebi.ac.uk/pdbsum/5h9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9l ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7YT09_RHOPR Q7YT09_RHOPR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rhopr~~]]	+	[[Category: Rhodnius prolixus]]
-	[[Category: Andersen~~, J F]]~~	+	[[Category: Andersen JF]]
-	~~[[Category: Leukotriene]]~~	+
-	~~[[Category: Lipocalin]]~~	+
-	~~[[Category: Rhodnius]]~~	+
-	~~[[Category: Salivary]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 06:56, 20 May 2020

OCA — Wed, 20 May 2020 06:56:33 GMT

←Older revision		Revision as of 06:56, 20 May 2020
Line 1:		Line 1:

	==Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4==		==Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4==
-	<StructureSection load='5h9l' size='340' side='right' caption='[[5h9l]], [[Resolution\|resolution]] 1.37Å' scene=''>	+	<StructureSection load='5h9l' size='340' side='right'caption='[[5h9l]], [[Resolution\|resolution]] 1.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5h9l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9L OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5H9L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5h9l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopr Rhopr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5H9L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EAH:(5S,7E,9E,11Z,14Z)-5-HYDROXYICOSA-7,9,11,14-TETRAENOIC+ACID'>EAH</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EAH:(5S,7E,9E,11Z,14Z)-5-HYDROXYICOSA-7,9,11,14-TETRAENOIC+ACID'>EAH</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5h9n\|5h9n]], [[5ha0\|5ha0]], [[5hae\|5hae]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5h9n\|5h9n]], [[5ha0\|5ha0]], [[5hae\|5hae]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5h9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9l OCA], [http://pdbe.org/5h9l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9l RCSB], [http://www.ebi.ac.uk/pdbsum/5h9l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9l ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5h9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9l OCA], [http://pdbe.org/5h9l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9l RCSB], [http://www.ebi.ac.uk/pdbsum/5h9l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9l ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Rhopr]]
	[[Category: Andersen, J F]]		[[Category: Andersen, J F]]
	[[Category: Leukotriene]]		[[Category: Leukotriene]]

OCA at 08:12, 27 July 2016

OCA — Wed, 27 Jul 2016 08:12:16 GMT

←Older revision		Revision as of 08:12, 27 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EAH:(5S,7E,9E,11Z,14Z)-5-HYDROXYICOSA-7,9,11,14-TETRAENOIC+ACID'>EAH</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EAH:(5S,7E,9E,11Z,14Z)-5-HYDROXYICOSA-7,9,11,14-TETRAENOIC+ACID'>EAH</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5h9n\|5h9n]], [[5ha0\|5ha0]], [[5hae\|5hae]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5h9n\|5h9n]], [[5ha0\|5ha0]], [[5hae\|5hae]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9l OCA], [http://pdbe.org/5h9l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9l RCSB], [http://www.ebi.ac.uk/pdbsum/5h9l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9l OCA], [http://pdbe.org/5h9l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9l RCSB], [http://www.ebi.ac.uk/pdbsum/5h9l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9l ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:59, 15 May 2016

OCA — Sun, 15 May 2016 16:59:59 GMT

←Older revision		Revision as of 16:59, 15 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5h9l is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4==
		+	<StructureSection load='5h9l' size='340' side='right' caption='[[5h9l]], [[Resolution\|resolution]] 1.37Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5h9l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H9L FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EAH:(5S,7E,9E,11Z,14Z)-5-HYDROXYICOSA-7,9,11,14-TETRAENOIC+ACID'>EAH</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5h9n\|5h9n]], [[5ha0\|5ha0]], [[5hae\|5hae]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9l OCA], [http://pdbe.org/5h9l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9l RCSB], [http://www.ebi.ac.uk/pdbsum/5h9l PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Blood-feeding disease vectors mitigate the negative effects of hemostasis and inflammation through the binding of small-molecule agonists of these processes by salivary proteins. In this study, a lipocalin protein family member (LTBP1) from the saliva of Rhodnius prolixus, a vector of the pathogen Trypanosoma cruzi, is shown to sequester cysteinyl leukotrienes during feeding to inhibit immediate inflammatory responses. Calorimetric binding experiments showed that LTBP1 binds leukotrienes C4 (LTC4), D4 (LTD4), and E4 (LTE4) but not biogenic amines, adenosine diphosphate, or other eicosanoid compounds. Crystal structures of ligand-free LTBP1 and its complexes with LTC4 and LTD4 reveal a conformational change during binding that brings Tyr114 into close contact with the ligand. LTC4 is cleaved in the complex, leaving free glutathione and a C20 fatty acid. Chromatographic analysis of bound ligands showed only intact LTC4, suggesting that cleavage could be radiation-mediated.

-	~~Authors: Andersen~~, J.F.	+	Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.,Jablonka W, Pham V, Nardone G, Gittis A, Silva-Cardoso L, Atella GC, Ribeiro JM, Andersen JF ACS Chem Biol. 2016 May 12. PMID:27124118<ref>PMID:27124118</ref>

-	~~Description: Crystal Structure~~ of ~~LTBP1 in complex with cleaved~~ Leukotriene C4	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Andersen, J.F~~]]	+	<div class="pdbe-citations 5h9l" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Andersen, J F]]
		+	[[Category: Leukotriene]]
		+	[[Category: Lipocalin]]
		+	[[Category: Rhodnius]]
		+	[[Category: Salivary]]
		+	[[Category: Transport protein]]

OCA at 18:41, 13 January 2016

OCA — Wed, 13 Jan 2016 18:41:45 GMT

←Older revision		Revision as of 18:41, 13 January 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5h9l is ON HOLD	+	The entry 5h9l is ON HOLD until Paper Publication

	Authors: Andersen, J.F.		Authors: Andersen, J.F.

OCA: Protected "5h9l" [edit=sysop:move=sysop]

OCA — Thu, 07 Jan 2016 10:21:35 GMT

Protected "5h9l" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:21, 7 January 2016

OCA: New page: '''Unreleased structure''' The entry 5h9l is ON HOLD Authors: Andersen, J.F. Description: Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4 [[Category: Unreleased Struc...

OCA — Thu, 07 Jan 2016 10:21:34 GMT

New page: '''Unreleased structure''' The entry 5h9l is ON HOLD Authors: Andersen, J.F. Description: Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4 [[Category: Unreleased Struc...

New page

'''Unreleased structure'''

The entry 5h9l is ON HOLD

Authors: Andersen, J.F.

Description: Crystal Structure of LTBP1 in complex with cleaved Leukotriene C4
[[Category: Unreleased Structures]]
[[Category: Andersen, J.F]]