5h9m - Revision history

OCA at 07:28, 9 August 2023

OCA — Wed, 09 Aug 2023 07:28:06 GMT

←Older revision		Revision as of 07:28, 9 August 2023
Line 3:		Line 3:
	<StructureSection load='5h9m' size='340' side='right'caption='[[5h9m]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='5h9m' size='340' side='right'caption='[[5h9m]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5h9m]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5H9M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5h9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H9M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.761Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIAH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5h9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9m OCA], [~~http~~://pdbe.org/5h9m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5h9m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5h9m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9m OCA], [https://pdbe.org/5h9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h9m RCSB], [https://www.ebi.ac.uk/pdbsum/5h9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SIAH2_HUMAN SIAH2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.<ref>PMID:11483518</ref> <ref>PMID:12411493</ref> <ref>PMID:19224863</ref> <ref>PMID:22878263</ref> <ref>PMID:9334332</ref>	+	[https://www.uniprot.org/uniprot/SIAH2_HUMAN SIAH2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.<ref>PMID:11483518</ref> <ref>PMID:12411493</ref> <ref>PMID:19224863</ref> <ref>PMID:22878263</ref> <ref>PMID:9334332</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Dong, A]]	+	[[Category: Dong A]]
-	[[Category: Edwards~~, A M]]~~	+	[[Category: Edwards AM]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Tong Y]]
-	[[Category: Tong, Y]]	+	[[Category: Walker JR]]
-	[[Category: Walker~~, J R~~]]	+	[[Category: Zhang Q]]
-	[[Category: Zhang, Q]]	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Sbd]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Siah2~~]]	+

OCA at 06:56, 20 May 2020

OCA — Wed, 20 May 2020 06:56:43 GMT

←Older revision		Revision as of 06:56, 20 May 2020
Line 1:		Line 1:

	==Crystal structure of siah2 SBD domain==		==Crystal structure of siah2 SBD domain==
-	<StructureSection load='5h9m' size='340' side='right' caption='[[5h9m]], [[Resolution\|resolution]] 1.76Å' scene=''>	+	<StructureSection load='5h9m' size='340' side='right'caption='[[5h9m]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5h9m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9M OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5H9M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5h9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5H9M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5h9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9m OCA], [http://pdbe.org/5h9m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9m RCSB], [http://www.ebi.ac.uk/pdbsum/5h9m PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SIAH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5h9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9m OCA], [http://pdbe.org/5h9m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9m RCSB], [http://www.ebi.ac.uk/pdbsum/5h9m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h9m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SIAH2_HUMAN SIAH2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.<ref>PMID:11483518</ref> <ref>PMID:12411493</ref> <ref>PMID:19224863</ref> <ref>PMID:22878263</ref> <ref>PMID:9334332</ref>		[[http://www.uniprot.org/uniprot/SIAH2_HUMAN SIAH2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.<ref>PMID:11483518</ref> <ref>PMID:12411493</ref> <ref>PMID:19224863</ref> <ref>PMID:22878263</ref> <ref>PMID:9334332</ref>
		+
		+	==See Also==
		+	*[[Ubiquitin protein ligase 3D structures\|Ubiquitin protein ligase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 02:57, 21 February 2016

OCA — Sun, 21 Feb 2016 02:57:19 GMT

←Older revision		Revision as of 02:57, 21 February 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5h9m ~~is ON HOLD~~	+	==Crystal structure of siah2 SBD domain==
-		+	<StructureSection load='5h9m' size='340' side='right' caption='[[5h9m]], [[Resolution\|resolution]] 1.76Å' scene=''>
-	~~Authors~~: ~~Dong, A~~., ~~Zhang~~, Q., ~~Walker, J~~.R., ~~Bountra~~, C., ~~Arrowsmith, C~~.H., ~~Edwards~~, A.M., ~~Tong~~, Y., ~~Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5h9m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H9M FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of siah2 SBD domain~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h9m OCA], [http://pdbe.org/5h9m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h9m RCSB], [http://www.ebi.ac.uk/pdbsum/5h9m PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SIAH2_HUMAN SIAH2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA.<ref>PMID:11483518</ref> <ref>PMID:12411493</ref> <ref>PMID:19224863</ref> <ref>PMID:22878263</ref> <ref>PMID:9334332</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
	[[Category: Dong, A]]		[[Category: Dong, A]]
-	[[Category: ~~Walker~~, ~~J.R~~]]	+	[[Category: Edwards, A M]]
-	[[Category: ~~Bountra, C]]~~	+	[[Category: Structural genomic]]
-	~~[[Category: Arrowsmith, C.H~~]]	+
	[[Category: Tong, Y]]		[[Category: Tong, Y]]
-	[[Category: ~~Edwards~~, ~~A.M]]~~	+	[[Category: Walker, J R]]
-	~~[[Category: Structural Genomics Consortium (Sgc)~~]]	+
	[[Category: Zhang, Q]]		[[Category: Zhang, Q]]
		+	[[Category: Ligase]]
		+	[[Category: Sbd]]
		+	[[Category: Sgc]]
		+	[[Category: Siah2]]

OCA: Protected "5h9m" [edit=sysop:move=sysop]

OCA — Thu, 07 Jan 2016 10:21:39 GMT

Protected "5h9m" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:21, 7 January 2016

OCA: New page: '''Unreleased structure''' The entry 5h9m is ON HOLD Authors: Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (...

OCA — Thu, 07 Jan 2016 10:21:37 GMT

New page: '''Unreleased structure''' The entry 5h9m is ON HOLD Authors: Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (...

New page

'''Unreleased structure'''

The entry 5h9m is ON HOLD

Authors: Dong, A., Zhang, Q., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)

Description: Crystal structure of siah2 SBD domain
[[Category: Unreleased Structures]]
[[Category: Dong, A]]
[[Category: Walker, J.R]]
[[Category: Bountra, C]]
[[Category: Arrowsmith, C.H]]
[[Category: Tong, Y]]
[[Category: Edwards, A.M]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Zhang, Q]]