5hcg - Revision history

OCA at 07:30, 9 August 2023

OCA — Wed, 09 Aug 2023 07:30:48 GMT

←Older revision		Revision as of 07:30, 9 August 2023
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	<StructureSection load='5hcg' size='340' side='right'caption='[[5hcg]], [[Resolution\|resolution]] 2.68Å' scene=''>		<StructureSection load='5hcg' size='340' side='right'caption='[[5hcg]], [[Resolution\|resolution]] 2.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hcg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HCG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5HCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hcg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HCG FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~5fhx~~\|~~5fhx~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.68Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5hcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hcg OCA], [~~http~~://pdbe.org/5hcg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hcg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hcg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hcg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hcg OCA], [https://pdbe.org/5hcg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hcg RCSB], [https://www.ebi.ac.uk/pdbsum/5hcg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hcg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dupuy, A]]	+	[[Category: Dupuy A]]
-	[[Category: Rak, A]]	+	[[Category: Rak A]]
-	[[Category: Vallee, F]]	+	[[Category: Vallee F]]
-	~~[[Category: Bispecific property]]~~	+
-	~~[[Category: Codv]]~~	+
-	~~[[Category: Cross-over dual variable immunoglobin]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Multifunctional biotherapeutic format~~]]	+

OCA at 06:59, 20 May 2020

OCA — Wed, 20 May 2020 06:59:51 GMT

←Older revision		Revision as of 06:59, 20 May 2020
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	==CRYSTAL STRUCTURE OF FREE-CODV.==		==CRYSTAL STRUCTURE OF FREE-CODV.==
-	<StructureSection load='5hcg' size='340' side='right' caption='[[5hcg]], [[Resolution\|resolution]] 2.68Å' scene=''>	+	<StructureSection load='5hcg' size='340' side='right'caption='[[5hcg]], [[Resolution\|resolution]] 2.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hcg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HCG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HCG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hcg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HCG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HCG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fhx\|5fhx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fhx\|5fhx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hcg OCA], [http://pdbe.org/5hcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hcg RCSB], [http://www.ebi.ac.uk/pdbsum/5hcg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hcg OCA], [http://pdbe.org/5hcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hcg RCSB], [http://www.ebi.ac.uk/pdbsum/5hcg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hcg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dupuy, A]]		[[Category: Dupuy, A]]
	[[Category: Rak, A]]		[[Category: Rak, A]]

OCA at 17:15, 10 May 2016

OCA — Tue, 10 May 2016 17:15:47 GMT

←Older revision		Revision as of 17:15, 10 May 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5hcg is ~~ON HOLD~~	+	==CRYSTAL STRUCTURE OF FREE-CODV.==
		+	<StructureSection load='5hcg' size='340' side='right' caption='[[5hcg]], [[Resolution\|resolution]] 2.68Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5hcg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HCG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HCG FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fhx\|5fhx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hcg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hcg OCA], [http://pdbe.org/5hcg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hcg RCSB], [http://www.ebi.ac.uk/pdbsum/5hcg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bispecific immunoglobulins (Igs) typically contain at least two distinct variable domains (Fv) that bind to two different target proteins. They are conceived to facilitate clinical development of biotherapeutic agents for diseases where improved clinical outcome is obtained or expected by combination therapy compared to treatment by single agents. Almost all existing formats are linear in their concept and differ widely in drug-like and manufacture-related properties. To overcome their major limitations, we designed cross-over dual variable Ig-like proteins (CODV-Ig). Their design is akin to the design of circularly closed repeat architectures. Indeed, initial results showed that the traditional approach of utilizing (G4S)x linkers for biotherapeutics design does not identify functional CODV-Igs. Therefore, we applied an unprecedented molecular modeling strategy for linker design that consistently results in CODV-Igs with excellent biochemical and biophysical properties. CODV architecture results in a circular self-contained structure functioning as a self-supporting truss that maintains the parental antibody affinities for both antigens without positional effects. The format is universally suitable for therapeutic applications targeting both circulating and membrane-localized proteins. Due to the full functionality of the Fc domains, serum half-life extension as well as antibody- or complement-dependent cytotoxicity may support biological efficiency of CODV-Igs. We show that judicious choice in combination of epitopes and paratope orientations of bispecific biotherapeutics is anticipated to be critical for clinical outcome. Uniting the major advantages of alternative bispecific biotherapeutics, CODV-Igs are applicable in a wide range of disease areas for fast-track multi-parametric drug optimization.

-	~~Authors: Vallee~~, F., ~~Dupuy~~, A., ~~Rak~~, A.	+	CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.,Steinmetz A, Vallee F, Beil C, Lange C, Baurin N, Beninga J, Capdevila C, Corvey C, Dupuy A, Ferrari P, Rak A, Wonerow P, Kruip J, Mikol V, Rao E MAbs. 2016 Mar 16:1-12. PMID:26984268<ref>PMID:26984268</ref>

-	~~Description: CRYSTAL STRUCTURE OF FREE-CODV~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Rak, A]]~~	+	<div class="pdbe-citations 5hcg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Dupuy, A]]		[[Category: Dupuy, A]]
		+	[[Category: Rak, A]]
	[[Category: Vallee, F]]		[[Category: Vallee, F]]
		+	[[Category: Bispecific property]]
		+	[[Category: Codv]]
		+	[[Category: Cross-over dual variable immunoglobin]]
		+	[[Category: Immune system]]
		+	[[Category: Multifunctional biotherapeutic format]]

OCA: Protected "5hcg" [edit=sysop:move=sysop]

OCA — Wed, 13 Jan 2016 18:48:50 GMT

Protected "5hcg" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:48, 13 January 2016

OCA: New page: '''Unreleased structure''' The entry 5hcg is ON HOLD Authors: Vallee, F., Dupuy, A., Rak, A. Description: CRYSTAL STRUCTURE OF FREE-CODV. Category: Unreleased Structures [[Category...

OCA — Wed, 13 Jan 2016 18:48:49 GMT

New page: '''Unreleased structure''' The entry 5hcg is ON HOLD Authors: Vallee, F., Dupuy, A., Rak, A. Description: CRYSTAL STRUCTURE OF FREE-CODV. Category: Unreleased Structures [[Category...

New page

'''Unreleased structure'''

The entry 5hcg is ON HOLD

Authors: Vallee, F., Dupuy, A., Rak, A.

Description: CRYSTAL STRUCTURE OF FREE-CODV.
[[Category: Unreleased Structures]]
[[Category: Rak, A]]
[[Category: Dupuy, A]]
[[Category: Vallee, F]]