5hfg - Revision history

OCA at 07:34, 9 August 2023

OCA — Wed, 09 Aug 2023 07:34:14 GMT

←Older revision		Revision as of 07:34, 9 August 2023
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	<StructureSection load='5hfg' size='340' side='right'caption='[[5hfg]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='5hfg' size='340' side='right'caption='[[5hfg]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hfg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5HFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hfg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HFG FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5hfi\|5hfi]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.823Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">PA0058 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=208964 PSEAE])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfg OCA], [https://pdbe.org/5hfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hfg RCSB], [https://www.ebi.ac.uk/pdbsum/5hfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfg ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5hfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfg OCA], [~~http~~://pdbe.org/5hfg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hfg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hfg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfg ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9I774_PSEAE Q9I774_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5hfg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5hfg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Thiol:disulfide interchange protein 3D structures\|Thiol:disulfide interchange protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Ha, N C]]	+	[[Category: Ha N-C]]
-	[[Category: Jo, I]]	+	[[Category: Jo I]]
-	~~[[Category: Disulfide reductase]]~~	+
-	~~[[Category: Dsb]]~~	+
-	~~[[Category: Dsbm]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Thioredoxin superfamlily~~]]	+

OCA at 07:03, 20 May 2020

OCA — Wed, 20 May 2020 07:03:58 GMT

←Older revision		Revision as of 07:03, 20 May 2020
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	==Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa==		==Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa==
-	<StructureSection load='5hfg' size='340' side='right' caption='[[5hfg]], [[Resolution\|resolution]] 1.82Å' scene=''>	+	<StructureSection load='5hfg' size='340' side='right'caption='[[5hfg]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hfg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HFG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hfg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HFG FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hfi\|5hfi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hfi\|5hfi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfg OCA], [http://pdbe.org/5hfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hfg RCSB], [http://www.ebi.ac.uk/pdbsum/5hfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfg ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA0058 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfg OCA], [http://pdbe.org/5hfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hfg RCSB], [http://www.ebi.ac.uk/pdbsum/5hfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pseae]]
	[[Category: Ha, N C]]		[[Category: Ha, N C]]
	[[Category: Jo, I]]		[[Category: Jo, I]]

OCA at 18:29, 26 October 2016

OCA — Wed, 26 Oct 2016 18:29:11 GMT

←Older revision		Revision as of 18:29, 26 October 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5hfg is ~~ON HOLD until Paper~~ Publication	+	==Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa==
		+	<StructureSection load='5hfg' size='340' side='right' caption='[[5hfg]], [[Resolution\|resolution]] 1.82Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5hfg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HFG FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hfi\|5hfi]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfg OCA], [http://pdbe.org/5hfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hfg RCSB], [http://www.ebi.ac.uk/pdbsum/5hfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfg ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In bacteria, many Dsb-family proteins play diverse roles in the conversion between the oxidized and reduced states of cysteine residues of substrate proteins. Most Dsb enzymes catalyze disulfide formation in periplasmic or secreted substrate proteins. Recently, a DsbM protein has been found in a Gram-negative bacterium, and was characterized as a cytosolic Dsb member with the conserved CXXC motif on the basis of sequence homology to the Dsb-family proteins. The protein was implicated in the reduction of the cytoplasmic redox-sensor protein OxyR in Pseudomonas aeruginosa. Here, crystal structures of DsbM from P. aeruginosa are presented, revealing that it consists of a modified thioredoxin domain containing the CXXC motif and a lid domain surrounding the CXXC motif. In a glutathione-linked structure, a glutathione molecule is linked to the CXXC motif of DsbM and is bound in an elongated cavity region in the thioredoxin domain, which is also suited for substrate peptide binding. A striking structural similarity to a human glutathione S-transferase was found in the glutathione-binding pocket. Further, biochemical evidence is presented suggesting that DsbM is directly involved in the reduction of the disulfide of Cys199 and Cys208 in OxyR, resulting in the acceleration of OxyR reduction in the absence of reactive oxygen species stress. These findings may help to expand the understanding of the diverse roles of redox-related proteins that contain the CXXC motif.

-	~~Authors: Jo~~, I~~., Ha~~, N.-C.	+	Crystal structures of the disulfide reductase DsbM from Pseudomonas aeruginosa.,Jo I, Park N, Chung IY, Cho YH, Ha NC Acta Crystallogr D Struct Biol. 2016 Oct 1;72(Pt 10):1100-1109. Epub 2016 Sep 15. PMID:27710931<ref>PMID:27710931</ref>

-	~~Description: Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: Ha, N.-C]]	+	<div class="pdbe-citations 5hfg" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ha, N C]]
	[[Category: Jo, I]]		[[Category: Jo, I]]
		+	[[Category: Disulfide reductase]]
		+	[[Category: Dsb]]
		+	[[Category: Dsbm]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Thioredoxin superfamlily]]

OCA at 11:15, 20 June 2016

OCA — Mon, 20 Jun 2016 11:15:35 GMT

←Older revision		Revision as of 11:15, 20 June 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5hfg is ON HOLD	+	The entry 5hfg is ON HOLD until Paper Publication

	Authors: Jo, I., Ha, N.-C.		Authors: Jo, I., Ha, N.-C.

OCA at 15:21, 20 January 2016

OCA — Wed, 20 Jan 2016 15:21:15 GMT

←Older revision		Revision as of 15:21, 20 January 2016
Line 3:		Line 3:
	The entry 5hfg is ON HOLD		The entry 5hfg is ON HOLD

-	Authors: ~~Inseong~~ Jo, ~~Nam-Chul~~ Ha	+	Authors: Jo, I., Ha, N.-C.

	Description: Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa		Description: Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Inseong Jo~~, ~~Nam~~-~~Chul Ha~~]]	+	[[Category: Ha, N.-C]]
		+	[[Category: Jo, I]]

OCA: Protected "5hfg" [edit=sysop:move=sysop]

OCA — Wed, 13 Jan 2016 18:58:37 GMT

Protected "5hfg" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:58, 13 January 2016

OCA: New page: '''Unreleased structure''' The entry 5hfg is ON HOLD Authors: Inseong Jo, Nam-Chul Ha Description: Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa [[Category: Unreleased...

OCA — Wed, 13 Jan 2016 18:58:35 GMT

New page: '''Unreleased structure''' The entry 5hfg is ON HOLD Authors: Inseong Jo, Nam-Chul Ha Description: Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa [[Category: Unreleased...

New page

'''Unreleased structure'''

The entry 5hfg is ON HOLD

Authors: Inseong Jo, Nam-Chul Ha

Description: Cytosolic disulfide reductase DsbM from Pseudomonas aeruginosa
[[Category: Unreleased Structures]]
[[Category: Inseong Jo, Nam-Chul Ha]]