5hhx - Revision history

OCA at 07:36, 9 August 2023

OCA — Wed, 09 Aug 2023 07:36:59 GMT

←Older revision		Revision as of 07:36, 9 August 2023
Line 1:		Line 1:

	==Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide==		==Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide==
-	<StructureSection load='5hhx' size='340' side='right' caption='[[5hhx]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='5hhx' size='340' side='right'caption='[[5hhx]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hhx]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HHX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hhx]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HHX FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hhv\|5hhv]]~~, [[~~5hi3~~\|~~5hi3]], [[5hi4\|5hi4]], [[5hi5\|5hi5~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~IL17A, CTLA8, IL17 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hhx OCA], [https://pdbe.org/5hhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hhx RCSB], [https://www.ebi.ac.uk/pdbsum/5hhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hhx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hhx OCA], [~~http~~://pdbe.org/5hhx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hhx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hhx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hhx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN]] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.	+	[https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5hhx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5hhx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Liu, S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Complex crystal structure~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Il-17]]~~	+	[[Category: Liu S]]
-	~~[[Category: Immune system-inhibitor complex]]~~	+
-	~~[[Category: Inflammation]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 09:59, 22 November 2017

OCA — Wed, 22 Nov 2017 09:59:27 GMT

←Older revision		Revision as of 09:59, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='5hhx' size='340' side='right' caption='[[5hhx]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='5hhx' size='340' side='right' caption='[[5hhx]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hhx]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hhx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HHX FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hhv\|5hhv]], [[5hi3\|5hi3]], [[5hi4\|5hi4]], [[5hi5\|5hi5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hhv\|5hhv]], [[5hi3\|5hi3]], [[5hi4\|5hi4]], [[5hi5\|5hi5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hhx OCA], [http://pdbe.org/5hhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hhx RCSB], [http://www.ebi.ac.uk/pdbsum/5hhx PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL17A, CTLA8, IL17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hhx OCA], [http://pdbe.org/5hhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hhx RCSB], [http://www.ebi.ac.uk/pdbsum/5hhx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hhx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Liu, S]]		[[Category: Liu, S]]
	[[Category: Complex crystal structure]]		[[Category: Complex crystal structure]]

OCA at 15:38, 1 June 2016

OCA — Wed, 01 Jun 2016 15:38:22 GMT

←Older revision		Revision as of 15:38, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5hhx is ~~ON HOLD until Paper~~ Publication	+	==Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide==
		+	<StructureSection load='5hhx' size='340' side='right' caption='[[5hhx]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5hhx]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HHX FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hhv\|5hhv]], [[5hi3\|5hi3]], [[5hi4\|5hi4]], [[5hi5\|5hi5]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hhx OCA], [http://pdbe.org/5hhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hhx RCSB], [http://www.ebi.ac.uk/pdbsum/5hhx PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN]] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	IL-17A is a pro-inflammatory cytokine that has been implicated in autoimmune and inflammatory diseases. Monoclonal antibodies inhibiting IL-17A signaling have demonstrated remarkable efficacy, but an oral therapy is still lacking. A high affinity IL-17A peptide antagonist (HAP) of 15 residues was identified through phage-display screening followed by saturation mutagenesis optimization and amino acid substitutions. HAP binds specifically to IL-17A and inhibits the interaction of the cytokine with its receptor, IL-17RA. Tested in primary human cells, HAP blocked the production of multiple inflammatory cytokines. Crystal structure studies revealed that two HAP molecules bind to one IL-17A dimer symmetrically. The N-terminal portions of HAP form a beta-strand that inserts between two IL-17A monomers while the C-terminal section forms an alpha helix that directly blocks IL-17RA from binding to the same region of IL-17A. This mode of inhibition suggests opportunities for developing peptide antagonists against this challenging target.

-	~~Authors:~~ Liu, S.	+	Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.,Liu S, Desharnais J, Sahasrabudhe PV, Jin P, Li W, Oates BD, Shanker S, Banker ME, Chrunyk BA, Song X, Feng X, Griffor M, Jimenez J, Chen G, Tumelty D, Bhat A, Bradshaw CW, Woodnutt G, Lappe RW, Thorarensen A, Qiu X, Withka JM, Wood LD Sci Rep. 2016 May 17;6:26071. doi: 10.1038/srep26071. PMID:27184415<ref>PMID:27184415</ref>

-	~~Description: Inhibiting complex IL-17A and IL-17RA interactions with~~ a ~~linear peptide~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5hhx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Liu, S]]		[[Category: Liu, S]]
		+	[[Category: Complex crystal structure]]
		+	[[Category: Il-17]]
		+	[[Category: Immune system-inhibitor complex]]
		+	[[Category: Inflammation]]
		+	[[Category: Inhibitor]]

OCA at 23:39, 10 May 2016

OCA — Tue, 10 May 2016 23:39:02 GMT

←Older revision		Revision as of 23:39, 10 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5hhx is ON HOLD	+	The entry 5hhx is ON HOLD until Paper Publication

-	Authors: ~~Lui~~, S.	+	Authors: Liu, S.

	Description: Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide		Description: Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Lui~~, S]]	+	[[Category: Liu, S]]

OCA at 13:47, 3 February 2016

OCA — Wed, 03 Feb 2016 13:47:37 GMT

←Older revision		Revision as of 13:47, 3 February 2016
Line 3:		Line 3:
	The entry 5hhx is ON HOLD		The entry 5hhx is ON HOLD

-	Authors: ~~Shenping Liu~~, Joel Desharnais, Parag V. Sahasrabudhe, Ping Jin, Wei Li, Bryan D. Oates, Suman Shanker, Mary Ellen Banker, Boris B. Chrunyk, Xi Song, Xidong Feng, Matt Griffor, Judith Jimenez, Gang Chen, David Tumelty, Abhijit Bhat, Curt W. Bradshaw, Gary Woodnutt, Rodney W. Lappe, Atli Thorarensen, Xiayang Qiu, Jane M. Withka and Lauren D. ~~Wood~~	+	Authors: Lui, S.

	Description: Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide		Description: Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Shenping Liu~~, Joel Desharnais, Parag V. Sahasrabudhe, Ping Jin, Wei Li, Bryan D. Oates, Suman Shanker, Mary Ellen Banker, Boris B. Chrunyk, Xi Song, Xidong Feng, Matt Griffor, Judith Jimenez, Gang Chen, David Tumelty, Abhijit Bhat, Curt W. Bradshaw, Gary Woodnutt, Rodney W. Lappe, Atli Thorarensen, Xiayang Qiu, Jane M. Withka And Lauren D. Wood]]	+	[[Category: Lui, S]]

OCA: Protected "5hhx" [edit=sysop:move=sysop]

OCA — Wed, 20 Jan 2016 15:27:53 GMT

Protected "5hhx" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:27, 20 January 2016

OCA: New page: '''Unreleased structure''' The entry 5hhx is ON HOLD Authors: Shenping Liu, Joel Desharnais, Parag V. Sahasrabudhe, Ping Jin, Wei Li, Bryan D. Oates, Suman Shanker, Mary Ellen Banker, B...

OCA — Wed, 20 Jan 2016 15:27:52 GMT

New page: '''Unreleased structure''' The entry 5hhx is ON HOLD Authors: Shenping Liu, Joel Desharnais, Parag V. Sahasrabudhe, Ping Jin, Wei Li, Bryan D. Oates, Suman Shanker, Mary Ellen Banker, B...

New page

'''Unreleased structure'''

The entry 5hhx is ON HOLD

Authors: Shenping Liu, Joel Desharnais, Parag V. Sahasrabudhe, Ping Jin, Wei Li, Bryan D. Oates, Suman Shanker, Mary Ellen Banker, Boris B. Chrunyk, Xi Song, Xidong Feng, Matt Griffor, Judith Jimenez, Gang Chen, David Tumelty, Abhijit Bhat, Curt W. Bradshaw, Gary Woodnutt, Rodney W. Lappe, Atli Thorarensen, Xiayang Qiu, Jane M. Withka and Lauren D. Wood

Description: Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
[[Category: Unreleased Structures]]
[[Category: Shenping Liu, Joel Desharnais, Parag V. Sahasrabudhe, Ping Jin, Wei Li, Bryan D. Oates, Suman Shanker, Mary Ellen Banker, Boris B. Chrunyk, Xi Song, Xidong Feng, Matt Griffor, Judith Jimenez, Gang Chen, David Tumelty, Abhijit Bhat, Curt W. Bradshaw, Gary Woodnutt, Rodney W. Lappe, Atli Thorarensen, Xiayang Qiu, Jane M. Withka And Lauren D. Wood]]