5hrj - Revision history

OCA at 10:51, 16 August 2023

OCA — Wed, 16 Aug 2023 10:51:50 GMT

←Older revision		Revision as of 10:51, 16 August 2023
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	<StructureSection load='5hrj' size='340' side='right'caption='[[5hrj]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5hrj' size='340' side='right'caption='[[5hrj]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hrj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HRJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5HRJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hrj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HRJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5hrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hrj OCA], [~~http~~://pdbe.org/5hrj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hrj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hrj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hrj ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hrj OCA], [https://pdbe.org/5hrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hrj RCSB], [https://www.ebi.ac.uk/pdbsum/5hrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hrj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/C163A_PIG C163A_PIG]] Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.<ref>PMID:14648288</ref> After shedding, the soluble form (sCD163) may play an anti-inflammatory role.	+	[https://www.uniprot.org/uniprot/C163A_PIG C163A_PIG] Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.<ref>PMID:14648288</ref> After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jiang, L]]	+	[[Category: Sus scrofa]]
-	[[Category: Li, R]]	+	[[Category: Jiang L]]
-	[[Category: Ma, H]]	+	[[Category: Li R]]
-	[[Category: Qiao, S]]	+	[[Category: Ma H]]
-	[[Category: Zhang, G]]	+	[[Category: Qiao S]]
-	~~[[Category: Balbes nmr]]~~	+	[[Category: Zhang G]]
-	~~[[Category: Cd163]]~~	+
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Prrsv]]~~	+
-	~~[[Category: Srcr~~]]	+

OCA at 08:29, 27 May 2020

OCA — Wed, 27 May 2020 08:29:09 GMT

←Older revision		Revision as of 08:29, 27 May 2020
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	==Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163==		==Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163==
-	<StructureSection load='5hrj' size='340' side='right' caption='[[5hrj]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5hrj' size='340' side='right'caption='[[5hrj]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hrj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HRJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HRJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hrj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HRJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HRJ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hrj OCA], [http://pdbe.org/5hrj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hrj RCSB], [http://www.ebi.ac.uk/pdbsum/5hrj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hrj ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hrj OCA], [http://pdbe.org/5hrj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hrj RCSB], [http://www.ebi.ac.uk/pdbsum/5hrj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hrj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Jiang, L]]		[[Category: Jiang, L]]
	[[Category: Li, R]]		[[Category: Li, R]]

OCA at 15:59, 20 October 2017

OCA — Fri, 20 Oct 2017 15:59:54 GMT

←Older revision		Revision as of 15:59, 20 October 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5hrj ~~is ON HOLD until Jul 19 2018~~	+	==Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163==
-		+	<StructureSection load='5hrj' size='340' side='right' caption='[[5hrj]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: Ma, H., ~~Jiang, L~~., ~~Qiao, S~~., ~~Zhang, G~~., ~~Li, R~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5hrj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HRJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HRJ FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of the ~~scavenger receptor cysteine~~-~~rich domain 5~~ (~~SRCR5~~) ~~from~~ porcine ~~CD163~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hrj OCA], [http://pdbe.org/5hrj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hrj RCSB], [http://www.ebi.ac.uk/pdbsum/5hrj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hrj ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/C163A_PIG C163A_PIG]] Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). May play a role in the process of infection of porcine monocytes/macrophages by African swine fever virus (ASFV). In case of porcine reproductive and respiratory syndrome virus (PRRSV), serves mediates virion attachment and plays a role in viral entry.<ref>PMID:14648288</ref> After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Jiang, L]]
		+	[[Category: Li, R]]
	[[Category: Ma, H]]		[[Category: Ma, H]]
	[[Category: Qiao, S]]		[[Category: Qiao, S]]
-	[[Category: Li, R]]
-	[[Category: Jiang, L]]
	[[Category: Zhang, G]]		[[Category: Zhang, G]]
		+	[[Category: Balbes nmr]]
		+	[[Category: Cd163]]
		+	[[Category: Endocytosis]]
		+	[[Category: Prrsv]]
		+	[[Category: Srcr]]

OCA at 11:11, 2 January 2017

OCA — Mon, 02 Jan 2017 11:11:11 GMT

←Older revision		Revision as of 11:11, 2 January 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5hrj is ON HOLD until ~~Paper Publication~~	+	The entry 5hrj is ON HOLD until Jul 19 2018

	Authors: Ma, H., Jiang, L., Qiao, S., Zhang, G., Li, R.		Authors: Ma, H., Jiang, L., Qiao, S., Zhang, G., Li, R.

OCA at 12:56, 2 March 2016

OCA — Wed, 02 Mar 2016 12:56:37 GMT

←Older revision		Revision as of 12:56, 2 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5hrj is ON HOLD	+	The entry 5hrj is ON HOLD until Paper Publication

	Authors: Ma, H., Jiang, L., Qiao, S., Zhang, G., Li, R.		Authors: Ma, H., Jiang, L., Qiao, S., Zhang, G., Li, R.

OCA at 15:38, 10 February 2016

OCA — Wed, 10 Feb 2016 15:38:04 GMT

←Older revision		Revision as of 15:38, 10 February 2016
Line 3:		Line 3:
	The entry 5hrj is ON HOLD		The entry 5hrj is ON HOLD

-	Authors: ~~Hongfang~~ Ma, ~~Longguang~~ Jiang, ~~Songlin~~ Qiao, ~~Gaiping~~ Zhang, ~~Rui~~ Li	+	Authors: Ma, H., Jiang, L., Qiao, S., Zhang, G., Li, R.

	Description: Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163		Description: Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Hongfang~~ Ma, ~~Longguang Jiang, Songlin~~ Qiao, ~~Gaiping~~ Zhang, ~~Rui Li~~]]	+	[[Category: Ma, H]]
		+	[[Category: Qiao, S]]
		+	[[Category: Li, R]]
		+	[[Category: Jiang, L]]
		+	[[Category: Zhang, G]]

OCA: Protected "5hrj" [edit=sysop:move=sysop]

OCA — Wed, 03 Feb 2016 14:13:15 GMT

Protected "5hrj" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:13, 3 February 2016

OCA: New page: '''Unreleased structure''' The entry 5hrj is ON HOLD Authors: Hongfang Ma, Longguang Jiang, Songlin Qiao, Gaiping Zhang, Rui Li Description: Crystal structure of the scavenger receptor...

OCA — Wed, 03 Feb 2016 14:13:14 GMT

New page: '''Unreleased structure''' The entry 5hrj is ON HOLD Authors: Hongfang Ma, Longguang Jiang, Songlin Qiao, Gaiping Zhang, Rui Li Description: Crystal structure of the scavenger receptor...

New page

'''Unreleased structure'''

The entry 5hrj is ON HOLD

Authors: Hongfang Ma, Longguang Jiang, Songlin Qiao, Gaiping Zhang, Rui Li

Description: Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163
[[Category: Unreleased Structures]]
[[Category: Hongfang Ma, Longguang Jiang, Songlin Qiao, Gaiping Zhang, Rui Li]]