5huj - Revision history

OCA at 10:54, 16 August 2023

OCA — Wed, 16 Aug 2023 10:54:21 GMT

←Older revision		Revision as of 10:54, 16 August 2023
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	<StructureSection load='5huj' size='340' side='right'caption='[[5huj]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5huj' size='340' side='right'caption='[[5huj]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5huj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HUJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5HUJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5huj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_NZ131 Streptococcus pyogenes NZ131]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HUJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5huh\|5huh]], [[5hup\|5hup]], [[5huo\|5huo]], [[5hul\|5hul]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/NAD(+)_synthase NAD(+) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.5 6.3.1.5]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5huj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5huj OCA], [https://pdbe.org/5huj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5huj RCSB], [https://www.ebi.ac.uk/pdbsum/5huj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5huj ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5huj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5huj OCA], [~~http~~://pdbe.org/5huj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5huj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5huj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5huj ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3BZ89_STRPZ A0A0H3BZ89_STRPZ]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5huj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5huj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[NAD synthase\|NAD synthase]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Booth, W T~~]]	+	[[Category: Streptococcus pyogenes NZ131]]
-	[[Category: ~~Chruszcz, M~~]]	+	[[Category: Booth WT]]
-	[[Category: ~~Transferase~~]]	+	[[Category: Chruszcz M]]

OCA at 08:32, 27 May 2020

OCA — Wed, 27 May 2020 08:32:58 GMT

←Older revision		Revision as of 08:32, 27 May 2020
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	==Crystal Structure of NadE from Streptococcus pyogenes==		==Crystal Structure of NadE from Streptococcus pyogenes==
-	<StructureSection load='5huj' size='340' side='right' caption='[[5huj]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5huj' size='340' side='right'caption='[[5huj]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5huj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HUJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HUJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5huj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HUJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HUJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5huh\|5huh]], [[5hup\|5hup]], [[5huo\|5huo]], [[5hul\|5hul]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5huh\|5huh]], [[5hup\|5hup]], [[5huo\|5huo]], [[5hul\|5hul]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_synthase NAD(+) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.5 6.3.1.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_synthase NAD(+) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.5 6.3.1.5] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5huj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5huj OCA], [http://pdbe.org/5huj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5huj RCSB], [http://www.ebi.ac.uk/pdbsum/5huj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5huj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5huj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5huj OCA], [http://pdbe.org/5huj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5huj RCSB], [http://www.ebi.ac.uk/pdbsum/5huj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5huj ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Booth, W T]]		[[Category: Booth, W T]]
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:03, 24 August 2017

OCA — Thu, 24 Aug 2017 11:03:51 GMT

←Older revision		Revision as of 11:03, 24 August 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5huj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5huj OCA], [http://pdbe.org/5huj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5huj RCSB], [http://www.ebi.ac.uk/pdbsum/5huj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5huj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5huj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5huj OCA], [http://pdbe.org/5huj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5huj RCSB], [http://www.ebi.ac.uk/pdbsum/5huj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5huj ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Streptococcus pyogenes, also known as Group A Strep (GAS), is an obligate human pathogen that is responsible for millions of infections and numerous deaths per year. Infection manifestations can range from simple, acute pharyngitis to more complex, necrotizing fasciitis. To date, most treatments for GAS infections involve the use of common antibiotics including tetracycline and clindamycin. Unfortunately, new strains have been identified that are resistant to these drugs, therefore, new targets must be identified to treat drug-resistant strains. This work is focused on the structural and functional characterization of three proteins: spNadC, spNadD, and spNadE. These enzymes are involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+ ). The structures of spNadC and spNadE were determined. SpNadC is suggested to play a role in GAS virulence, while spNadE, functions as an NAD synthetase and is considered to be a new drug target. Determination of the spNadE structure uncovered a putative, NH3 channel, which may provide insight into the mechanistic details of NH3 -dependent NAD+ synthetases in prokaryotes. ENZYMES: Quinolinate phosphoribosyltransferase: EC2.4.2.19 and NAD synthetase: EC6.3.1.5. DATABASE: Protein structures for spNadC, spNadCDelta69A , and spNadE are deposited into Protein Data Bank under the accession codes 5HUL, 5HUO & 5HUP, and 5HUH & 5HUJ, respectively.
		+
		+	Streptococcus pyogenes quinolinate-salvage pathway-structural and functional studies of quinolinate phosphoribosyl transferase and NH3 -dependent NAD+ synthetase.,Booth WT, Morris TL, Mysona DP, Shah MJ, Taylor LK, Karlin TW, Clary K, Majorek KA, Offermann LR, Chruszcz M FEBS J. 2017 Aug;284(15):2425-2441. doi: 10.1111/febs.14136. Epub 2017 Jul 7. PMID:28618168<ref>PMID:28618168</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5huj" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 23:43, 25 January 2017

OCA — Wed, 25 Jan 2017 23:43:12 GMT

←Older revision		Revision as of 23:43, 25 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5huj is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of NadE from Streptococcus pyogenes==
-		+	<StructureSection load='5huj' size='340' side='right' caption='[[5huj]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~: ~~Booth~~, W.T., ~~Chruszcz, M~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5huj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HUJ FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of NadE from Streptococcus pyogenes~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5huh\|5huh]], [[5hup\|5hup]], [[5huo\|5huo]], [[5hul\|5hul]]</td></tr>
-	[[Category: Booth, W.T]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_synthase NAD(+) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.1.5 6.3.1.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5huj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5huj OCA], [http://pdbe.org/5huj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5huj RCSB], [http://www.ebi.ac.uk/pdbsum/5huj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5huj ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Booth, W T]]
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]
		+	[[Category: Transferase]]

OCA at 15:44, 10 February 2016

OCA — Wed, 10 Feb 2016 15:44:11 GMT

←Older revision		Revision as of 15:44, 10 February 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5huj is ON HOLD	+	The entry 5huj is ON HOLD until Paper Publication

	Authors: Booth, W.T., Chruszcz, M.		Authors: Booth, W.T., Chruszcz, M.

OCA: Protected "5huj" [edit=sysop:move=sysop]

OCA — Wed, 03 Feb 2016 14:22:20 GMT

Protected "5huj" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:22, 3 February 2016

OCA: New page: '''Unreleased structure''' The entry 5huj is ON HOLD Authors: Booth, W.T., Chruszcz, M. Description: Crystal Structure of NadE from Streptococcus pyogenes [[Category: Unreleased Struct...

OCA — Wed, 03 Feb 2016 14:22:18 GMT

New page: '''Unreleased structure''' The entry 5huj is ON HOLD Authors: Booth, W.T., Chruszcz, M. Description: Crystal Structure of NadE from Streptococcus pyogenes [[Category: Unreleased Struct...

New page

'''Unreleased structure'''

The entry 5huj is ON HOLD

Authors: Booth, W.T., Chruszcz, M.

Description: Crystal Structure of NadE from Streptococcus pyogenes
[[Category: Unreleased Structures]]
[[Category: Booth, W.T]]
[[Category: Chruszcz, M]]