5hyd - Revision history

OCA at 11:00, 16 August 2023

OCA — Wed, 16 Aug 2023 11:00:19 GMT

←Older revision		Revision as of 11:00, 16 August 2023
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	<StructureSection load='5hyd' size='340' side='right'caption='[[5hyd]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5hyd' size='340' side='right'caption='[[5hyd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hyd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5HYD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hyd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HYD FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[2y5i\|2y5i]]~~, [[~~2wce~~\|~~2wce~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5hyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyd OCA], [~~http~~://pdbe.org/5hyd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hyd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hyd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyd OCA], [https://pdbe.org/5hyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hyd RCSB], [https://www.ebi.ac.uk/pdbsum/5hyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/S100Z_HUMAN S100Z_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Calderone, V]]	+	[[Category: Calderone V]]
-	[[Category: Fragai, M]]	+	[[Category: Fragai M]]
-	[[Category: Gallo, G]]	+	[[Category: Gallo G]]
-	[[Category: Luchinat, C]]	+	[[Category: Luchinat C]]
-	~~[[Category: Calcium-promoted oligomerisation neuronal development]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: S100~~]]	+

OCA at 08:36, 27 May 2020

OCA — Wed, 27 May 2020 08:36:44 GMT

←Older revision		Revision as of 08:36, 27 May 2020
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	==Crystal structure of calcium-free human S100Z==		==Crystal structure of calcium-free human S100Z==
-	<StructureSection load='5hyd' size='340' side='right' caption='[[5hyd]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5hyd' size='340' side='right'caption='[[5hyd]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hyd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HYD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hyd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HYD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y5i\|2y5i]], [[2wce\|2wce]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y5i\|2y5i]], [[2wce\|2wce]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyd OCA], [http://pdbe.org/5hyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyd RCSB], [http://www.ebi.ac.uk/pdbsum/5hyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyd OCA], [http://pdbe.org/5hyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyd RCSB], [http://www.ebi.ac.uk/pdbsum/5hyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyd ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5hyd" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5hyd" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[S100 proteins 3D structures\|S100 proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Calderone, V]]		[[Category: Calderone, V]]
	[[Category: Fragai, M]]		[[Category: Fragai, M]]

OCA at 18:00, 1 February 2017

OCA — Wed, 01 Feb 2017 18:00:46 GMT

←Older revision		Revision as of 18:00, 1 February 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5hyd is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of calcium-free human S100Z==
		+	<StructureSection load='5hyd' size='340' side='right' caption='[[5hyd]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5hyd]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYD FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2y5i\|2y5i]], [[2wce\|2wce]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyd OCA], [http://pdbe.org/5hyd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyd RCSB], [http://www.ebi.ac.uk/pdbsum/5hyd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyd ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The X-ray structure of human apo-S100Z has been solved and compared with that of the zebrafish calcium-bound S100Z, which is the closest in sequence. Human apo-S100A12, which shows only 43% sequence identity to human S100Z, has been used as template model to solve the crystallographic phase problem. Although a significant buried surface area between the two physiological dimers is present in the asymmetric unit of human apo-S100Z, the protein does not form the superhelical arrangement in the crystal as observed for the zebrafish calcium-bound S100Z and human calcium-bound S100A4. These findings further demonstrate that calcium plays a fundamental role in triggering quaternary structure formation in several S100s. Solving the X-ray structure of human apo-S100Z by standard molecular replacement procedures turned out to be a challenge and required trying different models and different software tools among which only one was successful. The model that allowed structure solution was that with one of the lowest sequence identity with the target protein among the S100 family in the apo state. Based on the previously solved zebrafish holo-S100Z, a putative human holo-S100Z structure has been then calculated through homology modeling; the differences between the experimental human apo and calculated holo structure have been compared to those existing for other members of the family.

-	~~Authors~~: ~~Calderone~~, V., Fragai, M., ~~Luchinat~~, C.~~, Gallo, G~~.	+	Solving the crystal structure of human calcium-free S100Z: the siege and conquer of one of the last S100 family strongholds.,Calderone V, Fragai M, Gallo G, Luchinat C J Biol Inorg Chem. 2017 Jan 10. doi: 10.1007/s00775-017-1437-4. PMID:28074300<ref>PMID:28074300</ref>

-	~~Description: Crystal structure~~ of ~~calcium-free human S100Z~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5hyd" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Calderone, V]]		[[Category: Calderone, V]]
	[[Category: Fragai, M]]		[[Category: Fragai, M]]
	[[Category: Gallo, G]]		[[Category: Gallo, G]]
	[[Category: Luchinat, C]]		[[Category: Luchinat, C]]
		+	[[Category: Calcium-promoted oligomerisation neuronal development]]
		+	[[Category: Protein binding]]
		+	[[Category: S100]]

OCA at 00:02, 11 May 2016

OCA — Wed, 11 May 2016 00:02:41 GMT

←Older revision		Revision as of 00:02, 11 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5hyd is ON HOLD	+	The entry 5hyd is ON HOLD until Paper Publication

	Authors: Calderone, V., Fragai, M., Luchinat, C., Gallo, G.		Authors: Calderone, V., Fragai, M., Luchinat, C., Gallo, G.

-	Description: ~~Calcium~~-free human S100Z	+	Description: Crystal structure of calcium-free human S100Z
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Calderone, V]]		[[Category: Calderone, V]]

OCA: Protected "5hyd" [edit=sysop:move=sysop]

OCA — Wed, 10 Feb 2016 15:53:51 GMT

Protected "5hyd" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:53, 10 February 2016

OCA: New page: '''Unreleased structure''' The entry 5hyd is ON HOLD Authors: Calderone, V., Fragai, M., Luchinat, C., Gallo, G. Description: Calcium-free human S100Z [[Category: Unreleased Structures...

OCA — Wed, 10 Feb 2016 15:53:49 GMT

New page: '''Unreleased structure''' The entry 5hyd is ON HOLD Authors: Calderone, V., Fragai, M., Luchinat, C., Gallo, G. Description: Calcium-free human S100Z [[Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 5hyd is ON HOLD

Authors: Calderone, V., Fragai, M., Luchinat, C., Gallo, G.

Description: Calcium-free human S100Z
[[Category: Unreleased Structures]]
[[Category: Calderone, V]]
[[Category: Fragai, M]]
[[Category: Gallo, G]]
[[Category: Luchinat, C]]