5hzw - Revision history

OCA at 08:18, 23 August 2023

OCA — Wed, 23 Aug 2023 08:18:39 GMT

←Older revision		Revision as of 08:18, 23 August 2023
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	<StructureSection load='5hzw' size='340' side='right'caption='[[5hzw]], [[Resolution\|resolution]] 4.45Å' scene=''>		<StructureSection load='5hzw' size='340' side='right'caption='[[5hzw]], [[Resolution\|resolution]] 4.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hzw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5HZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hzw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HZW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MAL:MALTOSE'>MAL</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.451Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5i04\|5i04]]~~, ~~[[5hzv\|5hzv]]~~, ~~[[5i05\|5i05]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5hzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzw OCA], [~~http~~://pdbe.org/5hzw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hzw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hzw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzw OCA], [https://pdbe.org/5hzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hzw RCSB], [https://www.ebi.ac.uk/pdbsum/5hzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/EGLN_HUMAN EGLN_HUMAN] Heritable pulmonary arterial hypertension;Familial cerebral saccular aneurysm;Generalized juvenile polyposis/juvenile polyposis coli;Hereditary hemorrhagic telangiectasia. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~MALE_ECOLI MALE_ECOLI~~]~~] Involved~~ in the ~~high-affinity maltose membrane transport system MalEFGK~~. ~~Initial receptor~~ for ~~the active transport~~ of ~~and chemotaxis toward maltooligosaccharides~~. ~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/GDF2_HUMAN GDF2_HUMAN]] Potent circulating inhibitor~~ of angiogenesis. ~~Could be~~ involved in ~~bone formation~~. ~~Signals~~ through ~~the type I activin receptor ACVRL1 but not other Alks~~.<ref>PMID:~~18309101~~</ref> <ref>PMID:~~22799562~~</ref>	+	[https://www.uniprot.org/uniprot/EGLN_HUMAN EGLN_HUMAN] Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).[UniProtKB:Q63961]<ref>PMID:17540773</ref> <ref>PMID:21737454</ref> <ref>PMID:23300529</ref> <ref>PMID:7894484</ref> <ref>PMID:8370410</ref> <ref>PMID:1692830</ref> [https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Escherichia coli K-12]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bokhove, M]]	+	[[Category: Bokhove M]]
-	[[Category: Jovine, L]]	+	[[Category: Jovine L]]
-	[[Category: Saito, T]]	+	[[Category: Saito T]]
-	~~[[Category: Angiogenesis]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Orphan domain]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 08:38, 27 May 2020

OCA — Wed, 27 May 2020 08:38:44 GMT

←Older revision		Revision as of 08:38, 27 May 2020
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	==Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9==		==Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9==
-	<StructureSection load='5hzw' size='340' side='right' caption='[[5hzw]], [[Resolution\|resolution]] 4.45Å' scene=''>	+	<StructureSection load='5hzw' size='340' side='right'caption='[[5hzw]], [[Resolution\|resolution]] 4.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hzw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HZW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hzw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HZW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5i04\|5i04]], [[5hzv\|5hzv]], [[5i05\|5i05]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5i04\|5i04]], [[5hzv\|5hzv]], [[5i05\|5i05]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzw OCA], [http://pdbe.org/5hzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hzw RCSB], [http://www.ebi.ac.uk/pdbsum/5hzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzw OCA], [http://pdbe.org/5hzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hzw RCSB], [http://www.ebi.ac.uk/pdbsum/5hzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5hzw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5hzw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Growth differentiation factor 3D STRUCTURES\|Growth differentiation factor 3D STRUCTURES]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bokhove, M]]		[[Category: Bokhove, M]]
	[[Category: Jovine, L]]		[[Category: Jovine, L]]

OCA at 09:40, 3 August 2017

OCA — Thu, 03 Aug 2017 09:40:19 GMT

←Older revision		Revision as of 09:40, 3 August 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5hzw is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of the orphan region of human endoglin/CD105 in complex with BMP9==
		+	<StructureSection load='5hzw' size='340' side='right' caption='[[5hzw]], [[Resolution\|resolution]] 4.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5hzw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HZW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5i04\|5i04]], [[5hzv\|5hzv]], [[5i05\|5i05]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzw OCA], [http://pdbe.org/5hzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hzw RCSB], [http://www.ebi.ac.uk/pdbsum/5hzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides. [[http://www.uniprot.org/uniprot/GDF2_HUMAN GDF2_HUMAN]] Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks.<ref>PMID:18309101</ref> <ref>PMID:22799562</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Endoglin (ENG)/CD105 is an essential endothelial cell co-receptor of the transforming growth factor beta (TGF-beta) superfamily, mutated in hereditary hemorrhagic telangiectasia type 1 (HHT1) and involved in tumor angiogenesis and preeclampsia. Here, we present crystal structures of the ectodomain of human ENG and its complex with the ligand bone morphogenetic protein 9 (BMP9). BMP9 interacts with a hydrophobic surface of the N-terminal orphan domain of ENG, which adopts a new duplicated fold generated by circular permutation. The interface involves residues mutated in HHT1 and overlaps with the epitope of tumor-suppressing anti-ENG monoclonal TRC105. The structure of the C-terminal zona pellucida module suggests how two copies of ENG embrace homodimeric BMP9, whose binding is compatible with ligand recognition by type I but not type II receptors. These findings shed light on the molecular basis of the BMP signaling cascade, with implications for future therapeutic interventions in this fundamental pathway.

-	~~Authors~~:	+	Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1.,Saito T, Bokhove M, Croci R, Zamora-Caballero S, Han L, Letarte M, de Sanctis D, Jovine L Cell Rep. 2017 May 30;19(9):1917-1928. doi: 10.1016/j.celrep.2017.05.011. PMID:28564608<ref>PMID:28564608</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5hzw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bokhove, M]]
		+	[[Category: Jovine, L]]
		+	[[Category: Saito, T]]
		+	[[Category: Angiogenesis]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Orphan domain]]
		+	[[Category: Receptor]]
		+	[[Category: Signaling protein]]

OCA at 11:59, 3 October 2016

OCA — Mon, 03 Oct 2016 11:59:18 GMT

←Older revision		Revision as of 11:59, 3 October 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5hzw is ON HOLD	+	The entry 5hzw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 10:19, 26 July 2016

OCA — Tue, 26 Jul 2016 10:19:49 GMT

←Older revision		Revision as of 10:19, 26 July 2016
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5hzw is ON HOLD ~~until Paper Publication~~	+	The entry 5hzw is ON HOLD

	Authors:		Authors:

OCA at 14:02, 15 May 2016

OCA — Sun, 15 May 2016 14:02:39 GMT

←Older revision		Revision as of 14:02, 15 May 2016
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	The entry 5hzw is ON HOLD until Paper Publication		The entry 5hzw is ON HOLD until Paper Publication

-	Authors: ~~Bokhove, M., Saito, T., Jovine, L.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bokhove, M]]
-	[[Category: Saito, T]]
-	[[Category: Jovine, L]]

OCA at 00:05, 11 May 2016

OCA — Wed, 11 May 2016 00:05:16 GMT

←Older revision		Revision as of 00:05, 11 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5hzw is ON HOLD	+	The entry 5hzw is ON HOLD until Paper Publication

	Authors: Bokhove, M., Saito, T., Jovine, L.		Authors: Bokhove, M., Saito, T., Jovine, L.

OCA: Protected "5hzw" [edit=sysop:move=sysop]

OCA — Wed, 10 Feb 2016 15:59:25 GMT

Protected "5hzw" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:59, 10 February 2016

OCA: New page: '''Unreleased structure''' The entry 5hzw is ON HOLD Authors: Bokhove, M., Saito, T., Jovine, L. Description: Category: Unreleased Structures Category: Bokhove, M [[Category: ...

OCA — Wed, 10 Feb 2016 15:59:23 GMT

New page: '''Unreleased structure''' The entry 5hzw is ON HOLD Authors: Bokhove, M., Saito, T., Jovine, L. Description: Category: Unreleased Structures Category: Bokhove, M [[Category: ...

New page

'''Unreleased structure'''

The entry 5hzw is ON HOLD

Authors: Bokhove, M., Saito, T., Jovine, L.

Description:
[[Category: Unreleased Structures]]
[[Category: Bokhove, M]]
[[Category: Saito, T]]
[[Category: Jovine, L]]