5i0q - Revision history

OCA at 08:19, 23 August 2023

OCA — Wed, 23 Aug 2023 08:19:27 GMT

←Older revision		Revision as of 08:19, 23 August 2023
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	<StructureSection load='5i0q' size='340' side='right'caption='[[5i0q]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='5i0q' size='340' side='right'caption='[[5i0q]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i0q]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5I0Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i0q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I0Q FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5hyu\|5hyu]], [[5hyp\|5hyp]], [[5hyt\|5hyt]], [[5hzp\|5hzp]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.293Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">emmL2~~.~~1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=1314 "Micrococcus scarlatinae" Klein 1884]), C4BPA, C4BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0q OCA], [https://pdbe.org/5i0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i0q RCSB], [https://www.ebi.ac.uk/pdbsum/5i0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0q ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5i0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0q OCA], [~~http~~://pdbe.org/5i0q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5i0q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5i0q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0q ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/M21_STRPY M21_STRPY]] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis. [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.	+	[https://www.uniprot.org/uniprot/M21_STRPY M21_STRPY] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Micrococcus scarlatinae klein 1884]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bahn-Suh, A J~~]]	+	[[Category: Streptococcus pyogenes]]
-	[[Category: ~~Buffalo, C Z~~]]	+	[[Category: Bahn-Suh AJ]]
-	[[Category: ~~Ghosh, P~~]]	+	[[Category: Buffalo CZ]]
-	[[Category: ~~Complement]]~~	+	[[Category: Ghosh P]]
-	~~[[Category: Hypervariable antigen]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: M protein]]~~	+
-	~~[[Category: Streptococcus pyogene~~]]	+

OCA at 08:40, 27 May 2020

OCA — Wed, 27 May 2020 08:40:00 GMT

←Older revision		Revision as of 08:40, 27 May 2020
Line 1:		Line 1:

	==Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of mutant group A Streptococcus M2 (K65A, N66A) protein==		==Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of mutant group A Streptococcus M2 (K65A, N66A) protein==
-	<StructureSection load='5i0q' size='340' side='right' caption='[[5i0q]], [[Resolution\|resolution]] 2.29Å' scene=''>	+	<StructureSection load='5i0q' size='340' side='right'caption='[[5i0q]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i0q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5I0Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i0q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5I0Q FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hyu\|5hyu]], [[5hyp\|5hyp]], [[5hyt\|5hyt]], [[5hzp\|5hzp]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hyu\|5hyu]], [[5hyp\|5hyp]], [[5hyt\|5hyt]], [[5hzp\|5hzp]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5i0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0q OCA], [http://pdbe.org/5i0q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i0q RCSB], [http://www.ebi.ac.uk/pdbsum/5i0q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0q ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">emmL2.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 "Micrococcus scarlatinae" Klein 1884]), C4BPA, C4BP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5i0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0q OCA], [http://pdbe.org/5i0q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i0q RCSB], [http://www.ebi.ac.uk/pdbsum/5i0q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Micrococcus scarlatinae klein 1884]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bahn-Suh, A J]]		[[Category: Bahn-Suh, A J]]
	[[Category: Buffalo, C Z]]		[[Category: Buffalo, C Z]]

OCA at 11:17, 26 October 2016

OCA — Wed, 26 Oct 2016 11:17:33 GMT

←Older revision		Revision as of 11:17, 26 October 2016
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/M21_STRPY M21_STRPY]] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis. [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.		[[http://www.uniprot.org/uniprot/M21_STRPY M21_STRPY]] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis. [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	No vaccine exists against group A Streptococcus (GAS), a leading cause of worldwide morbidity and mortality. A severe hurdle is the hypervariability of its major antigen, the M protein, with >200 different M types known. Neutralizing antibodies typically recognize M protein hypervariable regions (HVRs) and confer narrow protection. In stark contrast, human C4b-binding protein (C4BP), which is recruited to the GAS surface to block phagocytic killing, interacts with a remarkably large number of M protein HVRs (apparently approximately 90%). Such broad recognition is rare, and we discovered a unique mechanism for this through the structure determination of four sequence-diverse M proteins in complexes with C4BP. The structures revealed a uniform and tolerant 'reading head' in C4BP, which detected conserved sequence patterns hidden within hypervariability. Our results open up possibilities for rational therapies that target the M-C4BP interaction, and also inform a path towards vaccine design.
		+
		+	Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein.,Buffalo CZ, Bahn-Suh AJ, Hirakis SP, Biswas T, Amaro RE, Nizet V, Ghosh P Nat Microbiol. 2016 Sep 5:16155. doi: 10.1038/nmicrobiol.2016.155. PMID:27595425<ref>PMID:27595425</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5i0q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:35, 26 July 2016

OCA — Tue, 26 Jul 2016 15:35:14 GMT

←Older revision		Revision as of 15:35, 26 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5i0q is ON HOLD until Paper Publication~~	+	==Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of mutant group A Streptococcus M2 (K65A, N66A) protein==
-		+	<StructureSection load='5i0q' size='340' side='right' caption='[[5i0q]], [[Resolution\|resolution]] 2.29Å' scene=''>
-	~~Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5i0q]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I0Q FirstGlance]. <br>
-	~~Description:~~ Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of mutant group A Streptococcus M2 (K65A, N66A) protein	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hyu\|5hyu]], [[5hyp\|5hyp]], [[5hyt\|5hyt]], [[5hzp\|5hzp]]</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0q OCA], [http://pdbe.org/5i0q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i0q RCSB], [http://www.ebi.ac.uk/pdbsum/5i0q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0q ProSAT]</span></td></tr>
-	[[Category: Bahn-Suh, A.J]]	+	</table>
-	[[Category: Buffalo, C.Z]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/M21_STRPY M21_STRPY]] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis. [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bahn-Suh, A J]]
		+	[[Category: Buffalo, C Z]]
	[[Category: Ghosh, P]]		[[Category: Ghosh, P]]
		+	[[Category: Complement]]
		+	[[Category: Hypervariable antigen]]
		+	[[Category: Immune system]]
		+	[[Category: M protein]]
		+	[[Category: Streptococcus pyogene]]

OCA at 13:14, 2 March 2016

OCA — Wed, 02 Mar 2016 13:14:11 GMT

←Older revision		Revision as of 13:14, 2 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5i0q is ON HOLD	+	The entry 5i0q is ON HOLD until Paper Publication

	Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.		Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.

OCA: Protected "5i0q" [edit=sysop:move=sysop]

OCA — Wed, 10 Feb 2016 16:02:05 GMT

Protected "5i0q" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:02, 10 February 2016

OCA: New page: '''Unreleased structure''' The entry 5i0q is ON HOLD Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P. Description: Structure of human C4b-binding protein alpha chain CCP domains 1 and...

OCA — Wed, 10 Feb 2016 16:02:04 GMT

New page: '''Unreleased structure''' The entry 5i0q is ON HOLD Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P. Description: Structure of human C4b-binding protein alpha chain CCP domains 1 and...

New page

'''Unreleased structure'''

The entry 5i0q is ON HOLD

Authors: Buffalo, C.Z., Bahn-Suh, A.J., Ghosh, P.

Description: Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of mutant group A Streptococcus M2 (K65A, N66A) protein
[[Category: Unreleased Structures]]
[[Category: Bahn-Suh, A.J]]
[[Category: Buffalo, C.Z]]
[[Category: Ghosh, P]]